Relationship between psoas muscle index and long-term survival in older patients aged ≥ 80 years after endoscopic submucosal dissection for gastric cancer

Ito, Nobuhito; Funasaka, Kohei; Miyahara, Ryoji; Yamamura, Takeshi; Ishikawa, Takuya; Ohno, Eizaburo; Nakamura, Masanao; Kawashima, Hiroki; Hirooka, Yoshiki; Fujishiro, Mitsuhiro

doi:10.1007/s10147-021-02112-6

Cited by 12 publications

(14 citation statements)

References 26 publications

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“…According to Iwai et al., the long‐term post‐ESD prognosis of gastric cancer patients aged ≥80 years with a CCI of ≤2 was better than that of gastric cancer patients with a CCI of ≥3 who were aged <80 years 17 . We also reported that the long‐term prognosis of gastric cancer patients aged ≥80 years with a higher PMI was better than those with a lower PMI 23 . Although the relationships of each factor and the long‐term prognosis of elderly gastric cancer patients have been described previously, to the best of our knowledge, no previous studies have examined the relationships among such factors.…”

Section: Discussionsupporting

confidence: 54%

“…17 We also reported that the long-term prognosis of gastric cancer patients aged ≥80 years with a higher PMI was better than those with a lower PMI. 23 Although the relationships of each factor and the long-term prognosis of elderly gastric cancer patients have been described previously, to the best of our knowledge, no previous studies have examined the relationships among such factors. Our prognostic scoring system is the first trial to assess several prognostic factors comprehensively in elderly gastric cancer patients who undergo ESD.…”

Section: Discussionmentioning

confidence: 97%

“…[20][21][22] We previously reported that the long-term prognosis after ESD in gastric cancer patients aged ≥80 years with a high PMI was better than that in patients with a low PMI. 23 Furthermore, additional surgery in very elderly noncurative gastric cancer patients has not been shown to contribute to long-term prognosis, 24 and many of these patients die of other diseases during the postoperative period. 24,25 Thus, despite the identification of several prognostic factors after gastric ESD in elderly patients, their relationships are poorly discussed, with no comprehensive criteria for evaluating the post-ESD prognosis of elderly gastric cancer patients.…”

Section: Introductionmentioning

confidence: 99%

“…The psoas muscle index (PMI) 19 has been reported to be associated with long‐term prognosis in various cancers 20–22 . We previously reported that the long‐term prognosis after ESD in gastric cancer patients aged ≥80 years with a high PMI was better than that in patients with a low PMI 23 . Furthermore, additional surgery in very elderly noncurative gastric cancer patients has not been shown to contribute to long‐term prognosis, 24 and many of these patients die of other diseases during the postoperative period 24,25 .…”

Section: Introductionmentioning

confidence: 99%

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Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissection

Ito

Funasaka

Fujiyoshi

et al. 2022

Digestive Endoscopy

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Objectives: Comprehensive assessments of the long-term outcomes of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in the elderly are unavailable. We aimed to create a scoring system to predict the long-term prognosis after ESD for EGC among patients aged ≥75 years. Methods:We conducted retrospective studies of two cohorts: a single-center cohort (2006)(2007)(2008)(2009)(2010)(2011) for developing the scoring system, and a multicenter cohort for validating the developed system (2012-2016). In the development cohort, factors related to death after ESD were identified using multivariable Cox regression analysis, and a predictive scoring system was developed. In the validation cohort, the scoring system was validated in 295 patients.Results: In the development cohort, Charlson comorbidity index (CCI) ≥3 (hazard ratio [HR] 3.017), high psoas muscle index (PMI) (HR 2.206), and age ≥80 years (HR 1.978) were significantly related to overall survival after ESD. Therefore, high CCI, low PMI, and age ≥80 years were assigned 1 point each. The patients were categorized into low (≤1 point) and high (≥2 points) score groups based on their total scores. In the validation cohort, 184 and 111 patients were assigned to the low-and high-score groups, respectively. In comparisons based on Kaplan-Meier curves, the 5-year survival rate was 91.5% in the low-score group and 57.8% in the high-score group (log-rank test; P < 0.001). Conclusion:Our scoring system including high CCI, low PMI, and age ≥80 years could stratify the long-term prognosis of elderly patients aged ≥75 years after ESD for EGC.

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Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissection

Ito

Funasaka

Fujiyoshi

et al. 2022

Digestive Endoscopy

Self Cite

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“…In the studies by Hiroyuki Hisada-2024 [27], Hiroyuki Hisada-2022[28], Nobuhito Ito-2022 [30], Ga Hee Kim-2021 [31], data on the 5-year survival rates after ESD were provided for both the Sarcopenia and Nonsarcopenia groups. To facilitate a more convenient and accurate meta-analysis and statistics, we converted the 5-year survival rates into the number of patients who died within 5 years.…”

Section: Overall Survivalmentioning

confidence: 99%

Clinical significance of sarcopenia in elderly patients undergoing endoscopic submucosal dissection - A systematic review and meta-analysis

Su,

Wu,

et al. 2024

Preprint

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Background and Aims: As global life expectancy rises and gastrointestinal tumor incidence increases, more elderly patients are undergoing endoscopic submucosal dissection (ESD) for tumor treatment. This highlights the importance of sarcopenia assessment before ESD. This systematic review and meta-analysis aims to assess sarcopenia's role in predicting post-ESD adverse outcomes in the elderly. Methods: We conducted a systematic review and meta-analysis to investigate the impact of sarcopenia on the prognosis of elderly patients undergoing ESD treatment. A comprehensive search was conducted across three databases (PubMed, Embase, Web of Science). Using NEWCASTLE - OTTAWA ASSESSMENT SCALE for risk of bias assessment. The data were synthesized using Review Manager 5.3. Results: A total of 9 reports were identified, analyzing 7 indicators, with a combined sample size of 6044. Through a series of analyses, we have derived several highly credible research findings: the overall OR and 95% CI for gastric and colorectal post-ESD perforation between sarcopenia and nonsarcopenia groups were 1.34 [0.92, 1.97], for CTCAE grade > 2 were 2.65 [1.45, 4.82], for gastric post-ESD pneumonia were 1.90 [1.24, 2.90], and for gastric post-ESD mortality within 5 years were 2.96 [1.33, 6.58]. Conclusions: Sarcopenia is a risk factor for increased incidence of complications (CTCAE > 2) after undergoing gastric and colorectal ESD, increased pneumonia rates and higher mortality rates within five years following gastric ESD treatment in elderly patients. However, sarcopenia does not lead to an increased perforation rate in elderly patients undergoing gastric and colorectal ESD treatments.

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Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

Mei,

Wang,

Zhao

et al. 2024

Ibrain

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This study aims to explore the expression profile of PANoptosis‐related genes (PRGs) and immune infiltration in Alzheimer's disease (AD). Based on the Gene Expression Omnibus database, this study investigated the differentially expressed PRGs and immune cell infiltration in AD and explored related molecular clusters. Gene set variation analysis (GSVA) was used to analyze the expression of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes in different clusters. Weighted gene co‐expression network analysis was utilized to find co‐expressed gene modules and core genes in the network. By analyzing the intersection genes in random forest, support vector machine, generalized linear model, and extreme gradient boosting (XGB), the XGB model was determined. Eventually, the first five genes (Signal Transducer and Activator of Transcription 3, Tumor Necrosis Factor (TNF) Receptor Superfamily Member 1B, Interleukin 4 Receptor, Chloride Intracellular Channel 1, TNF Receptor Superfamily Member 10B) in XGB model were selected as predictive genes. This research explored the relationship between PANoptosis and AD and established an XGB learning model to evaluate and screen key genes. At the same time, immune infiltration analysis showed that there were different immune infiltration expression profiles in AD.

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Relationship between psoas muscle index and long-term survival in older patients aged ≥ 80 years after endoscopic submucosal dissection for gastric cancer

Cited by 12 publications

References 26 publications

Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissection

Scoring system for predicting the prognosis of elderly gastric cancer patients after endoscopic submucosal dissection

Clinical significance of sarcopenia in elderly patients undergoing endoscopic submucosal dissection - A systematic review and meta-analysis

Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

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