Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease

Sıncer, İsa; Zorlu, Ali; Yilmaz, Mehmet Birhan; Doǧan, Ömer Tamer; Ege, Meltem Refıker; Amioglu, Gullu; Aydın, Gülay; Ardıç, İdris; Tandoğan, İzzet

doi:10.1016/j.hrtlng.2011.07.011

Cited by 47 publications

(42 citation statements)

References 25 publications

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“…RDW is a biomarker that has been mostly studied in cardiac diseases, pneumonia, and pulmonary embolism [8][9][10][11]31]. Ozsu et al demonstrated that obstructive sleep apnea syndrome patients have an elevated RDW when compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…It is mainly used as a tool in the differential diagnosis of anemia, but the RDW may be elevated in any condition in which reticulocytes are released into the circulation such as inflammatory diseases and sepsis [6,7]. In addition to diagnosing anemia, recent studies have demonstrated that RDW also gives information regarding the prognosis of congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, obstructive sleep apnea syndrome, chronic obstructive pulmonary disease, sepsis, and other illnesses [7][8][9][10][11]. It is not completely understood why RDW is elevated in these patients, but it has been suggested that inflammation contributes to higher RDW levels [11].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

Abakay

Şen

et al. 2014

Inflammation

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We aimed to investigate the correlation between red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other inflammatory markers with pulmonary tuberculosis (PTB) severity. Seventy patients with active pulmonary tuberculosis were compared with 50 age-matched and gender-matched healthy controls. The mean age of PTB patients was 50.4±21.8 years. There were no differences in terms of age, gender, and smoking history between PTB patients and controls. Patients with advanced PTB had a significantly higher white blood cell count, neutrophil count, RDW, NLR, and C-reactive protein when compared to patients with mild to moderate PTB. RDW (17.7 versus 15.7 %, p=0.002) and NLR (4.7 versus 3.1, p=0.009) values were higher in patients with advanced PTB as opposed to patients with mild to moderate PTB. NLR and RDW levels may be used as markers of inflammation to help clinically manage patients with TB and to determine disease severity.KEY WORDS: inflammatory markers; neutrophil to lymphocyte ratio; pulmonary tuberculosis; radiological extent; red blood cell distribution width.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

Abakay

Şen

et al. 2014

Inflammation

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“…Grant has linked higher RDW values with worse pulmonary function tests in a cohort of patients without clinically evident respiratory diseases [12]. Similarly, Sincer has demonstrated a higher RDW in patients with COPD compared to a control group, even when corrected for known reasons for a high RDW such as folate, iron or vitamin B12 deficiencies [19]. The association between RDW and mortality has been shown in COPD patients [20].…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width (RDW) as a biomarker for respiratory failure in a pediatric ICU

et al. 2017

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BackgroundThe red cell distribution width (RDW) is a widely available, inexpensive, and highly reproducible test that reflects the range of the red cell sizes. Any process that releases reticulocytes in the circulation will result in an increase in RDW. Elevated RDW values are linked to worsened pulmonary function in the adult population. We performed a retrospective cohort study to describe the association between RDW and respiratory failure in critically ill children in a in a pediatric intensive care unit (PICU) in a tertiary university hospital.SubjectsAll patients admitted between January 2009 and June 2015 were considered eligible for inclusion.MethodsRetrospective cohort study.ResultsIn total, 960 patients were included in the cohort analysis. Of those patients, 149 (15.5%) had elevated RDW values. RDW on admission was associated with lower 28 day ventilator-free days. The highest quintile of RDW was associated with the need for mechanical ventilation, even when correcting for anaemia, age and Pediatric Risk of Mortality (PRISM) scores. In the subgroup of ventilated patients, RDW was associated with nadir PaO2/FiO2(P/F) ratios.ConclusionThe RDW value on admission of our PICU patients is associated with a greater need for invasive mechanical ventilation, lower 28 day ventilator-free days and lower nadir P/F ratios in the patients with highest RDW values on admission. RDW may be a valuable, cheap and universally available, prognostic parameter for respiratory dysfunction in the PICU.

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“…The majority of these patients will have a comorbid disease that is contributing to the degree of pulmonary hypertension [61]. In the right heart, objective findings that have been detected in COPD patients include concentric right ventricular (RV) hypertrophy and elevated end-diastolic RV pressures, one of the first manifestations of adjustment to elevated pulmonary artery pressures, followed by impaired relaxation and systolic dysfunction [57, 62]. RV systolic dysfunction is common in end-stage COPD, with one study documenting an average RV ejection fraction of 45 ± 9% [63].…”

Section: Cardiovascular Disease and Copd: Friend Or Foe?mentioning

confidence: 99%

Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Cardiovascular Links

Laratta

Eeden

2014

BioMed Research International

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Chronic obstructive pulmonary disease (COPD) is a chronic, progressive lung disease resulting from exposure to cigarette smoke, noxious gases, particulate matter, and air pollutants. COPD is exacerbated by acute inflammatory insults such as lung infections (viral and bacterial) and air pollutants which further accelerate the steady decline in lung function. The chronic inflammatory process in the lung contributes to the extrapulmonary manifestations of COPD which are predominantly cardiovascular in nature. Here we review the significant burden of cardiovascular disease in COPD and discuss the clinical and pathological links between acute exacerbations of COPD and cardiovascular disease.

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Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease

Cited by 47 publications

References 25 publications

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

Red cell distribution width (RDW) as a biomarker for respiratory failure in a pediatric ICU

Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Cardiovascular Links

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