Relationship between red cell distribution width and early renal injury in patients with gestational diabetes mellitus

Cheng, Dong; Zhao, Jiangtao; Jian, Liguo; Ding, Tongbin; Liu, Shichao

doi:10.1080/0886022x.2016.1207050

Cited by 3 publications

(5 citation statements)

References 26 publications

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“…[28] Similarly, Cheng et al found RDW to be an independent predictor of early stage renal injury in GDM patients. [29] In the present study we showed significantly increased RDW in GDM patients and in regression analysis RDW came out to be an independent predictor of GDM. Our study included 359 pregnant women and had a larger sample size than the aforementioned studies.…”

Section: Discussionsupporting

confidence: 63%

“…Erdogan et al retrospectively investigated 68 patients with GDM and 61 health controls. [15,28,29] They found no difference between RDW levels; however, Yildiz et al reported significantly increased RDW values in GDM patients. [28] Similarly, Cheng et al found RDW to be an independent predictor of early stage renal injury in GDM patients.…”

Section: Discussionmentioning

confidence: 99%

“…NRBC are immature erythrocytes, produced in response to increased erythropoietin which is secreted in cases of tissue hypoxia. [28,29] In infants there are studies that show elevated NRBC count in relation with complications like hypoxia, [40] hypoxemia, [41] asphyxia, maternal diabetes, prenatal brain damage, preterm infants, [18] RDS, [42] and preeclampsia. [43] Vatansever et al [18] demonstrated that serum erythropoietin concentrations were high in intrauterine growth restricted infants and infants of diabetic mothers.…”

Section: Discussionmentioning

confidence: 99%

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Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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To assess the role of simple complete blood count (CBC) in prediction of gestational diabetes (GDM). Material and Method: Pregnant women screened for GDM in 24-28 gestational weeks with a 75g-OGTT between January 2018-January 2020 were retrospectively investigated. Patients with a known systemic disease, using aspirin, low-molecular-weight heparin and steroids were excluded. A total of 359 patients (81 with GDM and 278 controls) were enrolled. The assessed parameters in CBC were hemoglobin, hematocrit, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin concentration, white blood cells (including neutrophils, lymphocytes, monocytes, eosinophils, basophils), platelets, platelet distribution width (PDW), mean platelet volume (MPV), red cell distribution width (RDW), nucleated red blood cell (NRBC), NRBC percentage, plateletcrit (PCT), platelet large cell ratio (P-LCR), immature granulocytes (IG) and IG percentage. Platelet mass index (PMI), neutrophil-tolymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) were calculated. These parameters were compared between GDM patients and controls. Regression analysis was performed with the parameters that were significantly correlated with GDM. ROC curve analysis was done in order to find cutoff values. Results: RBC, WBC (all subtypes including immature granulocytes), platelet indices including PMI, NLR and PLR were all similar. Only RDW and NRBC were found to be significantly increased in GDM patients and came out to be independent predictors of GDM with maternal age and screening week. Conclusion: These findings suggest that women with GDM may be accompanied with increased RDW and NRBC levels which seem to be independent predictors of this disease and these parameters may be used to monitor and evaluate the development of GDM.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Aytan

Babuş

Sakarya

et al. 2020

Journal of Contemporary Medicine

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“…In terms of albuminuria, Afonso et al [ 18 ] analyzed 8,499 representative participants in the National Health and Nutrition Examination Survey and found that elevated RDW was independently associated with microalbuminuria. A few other studies have demonstrated the same relationship in smaller, high-risk groups of patients such as those with hypertension or diabetes [ 15 , 16 , 23 ]. However, the studies described above were cross-sectional in design, and only two other small longitudinal studies have been performed.…”

Section: Discussionmentioning

confidence: 63%

Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease

Hyun

Kim

Lee

2017

Kidney Res Clin Pract.

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BackgroundRed cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with microalbuminuria, an indicator of target organ damage. However, the longitudinal association of RDW and development of albuminuria is not known.MethodsWe analyzed 83,040 participants without chronic kidney disease (CKD) at baseline who underwent two health check-ups at a 4-year interval during 2005 to 2014. Urine albumin was determined by single urine dipstick semi-quantitative analysis, and incident albuminuria was defined as ≥ 1+ dipstick albumin at the second check-up. We used logistic regression analysis to determine the relationship between RDW and incident albuminuria.ResultsParticipants were divided into quartiles according to baseline RDW. After 4 years, 982 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.94, 1.05, 1.18, and 1.62% for the 1st through 4th quartiles of RDW, respectively. Multivariate logistic analysis showed that the odds ratios (95% confidence interval) for incident albuminuria compared to those in the 1st quartile were 1.11 (0.92–1.34), 1.26 (1.04–1.52), and 1.88 (1.58–2.24) for the 2nd, 3rd and 4th quartiles, respectively.ConclusionRDW was associated with development of albuminuria in relatively healthy Korean adults without CKD. Further research is needed to verify the role of RDW in the development of albuminuria and renal injury.

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“…Cheng et al investigated a different potential diagnostic use of RDW in GDM ( 29 ). Using a cross-sectional design, they studied 334 pregnant women with GDM in order to evaluate the role of RDW in predicting early renal injury.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width in pregnancy: a systematic review

et al. 2018

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Anisocytosis has been associated with the severity and prognosis of several acute and chronic diseases, as well as physiological conditions such as pregnancy. Anisocytosis is quantified by the red blood cell distribution width (RDW), expressed as the ratio, multiplied by 100, between the standard deviation (SD) of red blood cell volumes and the mean corpuscular volume, or as the SD of erythrocyte volumes (RDW-SD). The aim of the present review was to report the state of the art on the physiological values and the putative diagnostic and prognostic roles of RDW in complicated pregnancy. Literature research for articles published in the last ten years was conducted in Pubmed, Web of Science, ClinicalTrials.gov, and Scopus databases. Abstracts were independently screened by two investigators. If relevant, full articles were retrieved. References, in these articles, citing relevant reviews or original studies were also accessed to identify additional eligible studies. Any disagreement between the reviewers was resolved by a third investigator. A total of 28 studies were included in the review. These studies reported changes in RDW values during physiological pregnancy, and associations between the RDW and several pregnancy complications including anaemia, preeclampsia, gestational diabetes, and recurrent miscarriage. This review provides background information for establishing physiological and pathological RDW values in pregnancy for diagnostic and prognostic use in clinical practice.

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Relationship between red cell distribution width and early renal injury in patients with gestational diabetes mellitus

Cited by 3 publications

References 26 publications

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Basit Bir Tam Kan Sayımı Gestastonel Diyabetes Mellitusu Öngörebilir Mi?

Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease

Red blood cell distribution width in pregnancy: a systematic review

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