Relationship Between Retinal Hemorrhage on Green and Red Channels of Ultra-Widefield Fundus Images and Retinal Perfusion in Acute Branch Retinal Vein Occlusion

Abstract

Purpose: To explore the relationship between retinal hemorrhage in the green and red channels on ultra-widefield fundus images (UWFIs) and the nonperfusion area (NPA) on ultra-widefield fundus fluorescein angiography in patients with acute branch retinal vein occlusion (BRVO). Methods: This was a retrospective cross-sectional study with 96 patients, including 46 with ischemic BRVO and 50 with nonischemic BRVO. Correlation analysis between green channel hemorrhage (GCH), red channel hemorrhage (RCH), and NPA was performed. Panretina was divided into posterior and peripheral areas. Results: Ischemic BRVO showed significantly higher GCH% and RCH% than nonischemic BRVO in the peripheral regions (both P < 0.001), while no significant differences were observed in the panretinal and posterior area (all P > 0.05). Significant correlations were found between NPA% in the panretinal and peripheral areas and the corresponding GCH% and RCH% (all P < 0.01). However, no significant correlation was observed between posterior NPA% and posterior GCH% or RCH% (both P > 0.05). Additionally, peripheral GCH% and RCH% were related to panretinal NPA% (r = 0.506, P < 0.001; r = 0.558, P < 0.001). Conclusion: Retinal hemorrhage on UWFI was significantly associated with NPA, providing insights for assessing retinal perfusion status in acute BRVO patients.