Relationship between retinal morphological findings and autoantibody profile in primary Sjögren’s syndrome

Yang, Jae‐Ho; Heo, Hwan; Park, Sang Woo

doi:10.1007/s10384-014-0327-3

Cited by 11 publications

(14 citation statements)

References 43 publications

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“…In this current study, although we could not measure the levels of BAFF in the serum of the participants, we postulated that the similarity between the pSS patients and healthy subjects with respect to the thickness of mGCIPL and pRNFL, except in the inferior quadrant, may have been a consequence of the reduced effects of HQ on the serum levels of BAFF in pSS patients (31) . This association may also be supported by the findings of Yang et al who found significant thinning of pRNFL in both the inferior and temporal quadrants as well as the thinning of mGCIPL in nearly all quadrants except the superonasal portion of the macula in pSS patients not under treatment with HQ (21,24) . In the current study, we determined that significant thinning of pRNFL in the inferior quadrant in pSS patients may have arisen from mild macular toxicity of HQ; this finding agreed with that reported by Pa sadhika (32) .…”

Section: Discussionsupporting

confidence: 78%

“…It has been reported previously that anti-Ro autoantibodies can play a role in mediating or potentiating vascular injury in the central nervous system (23) . A study by Yang et al indicated that these autoantibodies may also lead to improper apoptotic removal of the retinal ganglion cells (RGCs) by binding to the apoptotic RGCs, resulting in optic nerve damage (24) . Furthermore, in the same study, according to the OCT findings of pSS patients, a correlation was demonstrated between the thinning of pRNFL and mGCIPL and increased numbers of autoantibodies such as anti-Ro and anti-La (23) .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Arıkan¹,

Gökmen²,

Çömez³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Arıkan¹,

Gökmen²,

Çömez³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…We also evaluated pRNFL thickness by SD-OCT and identified reduced thicknesses in the temporal-inferior and the nasal-inferior sectors in SS patients compared with HC and SLE patients. Recent studies in SS patients have shown that the thickness of pRNFL in the inferior quadrants was compromised compared with HC due to dry eye disease or rarely optic neuropathy [44, 45]. This thinning might also be due to HCQ treatment or apoptosis of retinal ganglion cells induced by anti-Ro antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…Data from the literature suggest that anti-Ro antibodies could play a role in mediating or potentiating vascular injury in the central nervous system [48]. A study by Yang et al [45] indicated that these antibodies might also lead to improper removal of retinal ganglion cells by binding to apoptotic cells, resulting in optic nerve damage. Moreover, in the same study, a correlation was described between the thinning of pRNFL and increased numbers of anti-Ro and anti-La autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the Detection of Subclinical Retinal Involvement in Systemic Lupus Erythematosus and Sjögren Syndrome: A Potential Association with Therapies

Conigliaro

Triggianese

Draghessi

et al. 2018

Int Arch Allergy Immunol

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Background: Retinal involvement in systemic lupus erythematosus (SLE) and Sjögren syndrome (SS) may be subclinical and thus underdiagnosed. Objectives: We aimed at evaluating morphological and functional visual abnormalities in a cohort of SLE and SS patients in the absence of an overt clinical visual impairment. We also investigated potential associations between retinal disorders and disease activity, organ involvement, and treatment with steroid and/or hydroxychloroquine. Methods: The study comprised 42 SLE and 36 primary SS patients and 76 healthy controls (HC). Ophthalmological examination, standard automated perimetry, spectral-domain optical coherence tomography, and fundus perimetry were performed. Results: Retinal thickness of the posterior pole was not different between SLE and HC groups, but it was reduced in the SS group compared with both the HC and the SLE group. In SLE and SS patients, mean defect and pattern standard deviation by standard automated perimetry were higher than in HC. Visual field index values were lower in both SLE and SS patients than in HC. SLE patients with nephritis displayed increased mean defect and pattern standard deviation and reduced visual field index values compared to patients without nephritis. In SLE and SS patients, fundus perimetry differential sensitivity was reduced, and mean defect values were higher than in HC. Disturbances in fundus perimetry in the SLE group were more prevalent in steroid-naïve patients and in SS patients who received a cumulative hydroxychloroquine dose > 1,000 g. Conclusions: Functional eye impairment was demonstrated in SLE patients, possibly associated with kidney involvement. In SLE, corticosteroids might exert a protective role. Morphological alterations and functional impairment were detected in SS patients, which may be linked to hydroxychloroquine toxicity.

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“…Accumulating evidence suggests that a failure in the regulation of immunity or aberrant autoimmunity can initiate or aggravate the loss of RGC [ 10 – 13 ]. Our recent study has revealed that increased positivity for autoantibodies is associated with thinning of the peripapillary retinal nerve fiber layer (pRNFL) or macular ganglion cell–inner plexiform layer (mGCIPL) in patients with pSS [ 14 ]. However, our previous study did not quantify serum autoantibodies and did not evaluate other clinical factors, including histopathologic severity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Clinical Factors Associated with Retinal Morphological Changes in Patients with Primary Sjögren's Syndrome

Yang

Sung

et al. 2016

PLoS ONE

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PurposeTo investigate clinical factors associated with abnormal retinal morphologies in patients with primary Sjögren's syndrome (pSS).MethodsOne-hundred-thirty patients with pSS who underwent immunoserological tests, minor salivary gland biopsies, and optical coherence tomography examinations were retrospectively analyzed. Risk factors for abnormally reduced peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell–inner plexiform layer (mGCIPL) thicknesses were evaluated, as well as the correlation between clinical factors and pRNFL and mGCIPL thicknesses.ResultsAnti-Sjögren's syndrome type B (SSB) antibody positivity (P = 0.048) was identified as a risk factor associated with abnormally reduced pRNFL thickness, and anti-SSB positivity (P = 0.005) and erythrocyte sedimentation rate (ESR) level (P = 0.031) were identified as risk factors associated with an abnormally reduced mGCIPL thickness as revealed by multivariate logistic regression analysis. There was a significant negative correlation between anti-SSB antibody levels and the thickness of pRNFL and mGCIPL. The thicknesses of pRNFL and mGCIPL were significantly reduced in anti-SSB–positive eyes when compared to anti-SSB–negative eyes (P < 0.05). However, histopathologic grading was not associated with the pRNFL and mGCIPL thicknesses.ConclusionAnti-SSB antibody positivity and ESR levels may be useful for predicting an abnormally reduced pRNFL or mGCIPL thickness in patients with pSS. Our results may provide clinical evidence to substantiate the association between aberrant autoimmunity and inner retinal changes in patients with pSS.

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Relationship between retinal morphological findings and autoantibody profile in primary Sjögren’s syndrome

Abstract: Compared with controls, eyes with pSS showed thinning of pRNFL and mGCIPL thicknesses. The degree of thinning correlated with increased numbers of the positive autoantibody.

Cited by 11 publications

References 43 publications

Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Evaluation of possible factors affecting contrast sensitivity function in patients with primary Sjögren’s syndrome

Evidence for the Detection of Subclinical Retinal Involvement in Systemic Lupus Erythematosus and Sjögren Syndrome: A Potential Association with Therapies

Analysis of Clinical Factors Associated with Retinal Morphological Changes in Patients with Primary Sjögren's Syndrome

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