Relationship between rs9939609 <scp>FTO</scp> polymorphism with waist circumference and body fat is moderated by ponderal index at birth in youth

Alves, Fernanda Quevedo; Reuter, Cézane Priscila; Neumann, Igor; Todendi, Pâmela Ferreira; Brand, Caroline; Matos, William Latosinski; Brazo-Sayavera, Javier; Renner, Jane Dagmar Pollo; Valim, Andréia Rosane de Moura

doi:10.1002/ajhb.23575

Cited by 4 publications

(1 citation statement)

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“…Dedoussis and teammates [ 81 ] examined the interaction effect of the rs9939609 polymorphism with breastfeeding on WC in two independent cohorts of European children, and obtained a consistent result that the A allele is correlated with a greater WC only in those with less than one month of breastfeeding ( p < 0.05). Quevedo Alves et al [ 82 ] investigated the interaction effect of the rs9939609 polymorphism with ponderal index at birth on WC in a group of Brazilian children and adolescents aged 6–17 years and found that the subjects with the AA genotype had a higher average WC than those with the AT or TT genotype in the lower tertile (β = 4.40, p = 0.048), but not in the middle or upper tertile, of the ponderal index.…”

Section: Some Genetic Polymorphisms Of Fto Increas...mentioning

confidence: 99%

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

et al. 2023

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Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphisms in intron 1, such as rs9939609 and rs9930506 polymorphisms, are significantly associated with the development of MetS in children and adolescents. Mechanistic studies reported that FTO polymorphisms lead to aberrant expressions of FTO and the adjacent genes that promote adipogenesis and appetite and reduce steatolysis, satiety, and energy expenditure in the carriers. The present review highlights the recent observations on the key FTO polymorphisms that are associated with child and adolescent MetS with an exploration of the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia in child and adolescent MetS.

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Section: Some Genetic Polymorphisms Of Fto Increas...mentioning

confidence: 99%

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

et al. 2023

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Direct-to-consumer genetic test and lifestyle questionnaire analysis of body mass index and body fat percentage in a large Korean population

Kim

Park²,

Lee³

et al. 2022

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Background Direct-to-consumer (DTC) genetic testing provides genetic risk to consumers and motivates consumers to take care of their own customized health care. In 2018, we developed and provided a DTC genetic testing service (GENESTART™) in collaboration with Herbalife Korea Co. Ltd. Methods The analyzed dataset consisted of the body fat percentage (BFP), body mass index (BMI), 31 genetic polymorphism genotypes, and responses to 19 questionnaire items of 24,447 individuals. The genetic main effects for BFP and BMI were examined by linear regression analysis, and the interaction effects were examined using a generalized linear model that controlled age and sex as covariates. In the case of BFP, the sample average was 31.47% overall, 24.76% for men, and 32.79% for women, showing that men had an average BFP that was 8 percentage points lower than that of women. The average BMI was 25.38 overall, 26.45 for men, and 25.17 for women, showing that men had an average BMI of 1.2 kg/m2 higher than that of women. Results The FTO and MC4R genes, well-known obesity markers, showed a significant correlation with both phenotypes, and the BDNF gene, which is related to stress obesity, showed a highly significant association with BMI but only a weak association with BFP. Among the remaining genes, TRIB1, ABCA1, MYL2, G6PC, GCKR, GLIS3, CYP17A1, HECTD4, and NT5C2 genes showed significant associations with the obesity-related phenotypes. In this study, we found four interaction results for BFP (ABO and fruits, CYP1A2 and sugary foods, FTO and muscle exercise, MC4R and vitamins) and five interactions for BMI (MC4R and proteins, CSK and fruits, MC4R and calcium, DGKB and calcium, CSK and water). Conclusions This study is expected to enable the provision of personalized and accurate solutions for BFP and BMI management to customers who have undergone genetic testing.

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Genetic Association of FTO gene variants (rs17817449 T>G and rs9939609 T>A) with obesity and its related Phenotypes in North Indian Punjabi Population

Sharma

Professor

2023

Preprint

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Fat mass and obesity associated (FTO) gene belongs to the non-heme Fe (II) and 2 oxoglutarate dependent dioxygenase superfamily. FTO gene has been evolved as a potent genetic risk factor for the development of obesity. To establish the potential association between FTO rs17817449 T > G and rs9939609 T > A polymorphisms and obesity risk in north Indian Punjabi population, a total of 333 obese and 338 non-obese control subjects were randomly selected. Both the FTO gene polymorphisms rs17817449 (TT vs GG: odds ratio (OR), 2.30; 95% confidence interval (CI), 1.39–3.79) and rs9939609 (TT vs AA: odds ratio (OR), 2.78; 95% confidence interval (CI), 1.37–5.64) were significantly associated with obesity and conferred 2-fold and 3-fold risk toward the development of obesity respectively. Logistic regression analysis determined the significant association under the recessive genetic model (OR = 2.29; 95%CI: 1.47–3.57) and (OR = 5.25; 95%CI: 2.68–10.28) respectively for rs17817449 and rs9939609 thereby confirming the major role of environmental and anthropometric factors in this population. Haplotype analysis revealed that TA haplotype conferred 4-fold risk towards obesity (p = 0.0001). The rs17817449G allele and the obesity associated covariates accounted for 55%, 49%, 42%, 34%, 31% and 22% variability in body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride (TG) respectively. For rs9939609A allele contributed 98%, 82%, 54%, 59%, 71% and 84% variability in BMI, WC, WHtR, SBP, DBP, TG respectively in obese individuals. Therefore, the present study suggested that both the polymorphisms of FTO gene (rs17817449 T > G and rs9939609 T > A) are relevant markers of obesity in the north Indian Punjabi population and both plays an important role in an individual’s predisposition towards obesity.

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Relationship between rs9939609 FTO polymorphism with waist circumference and body fat is moderated by ponderal index at birth in youth

Cited by 4 publications

References 32 publications

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Direct-to-consumer genetic test and lifestyle questionnaire analysis of body mass index and body fat percentage in a large Korean population

Genetic Association of FTO gene variants (rs17817449 T>G and rs9939609 T>A) with obesity and its related Phenotypes in North Indian Punjabi Population

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Relationship between rs9939609 FTO polymorphism with waist circumference and body fat is moderated by ponderal index at birth in youth

Cited by 4 publications

References 32 publications

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Direct-to-consumer genetic test and lifestyle questionnaire analysis of body mass index and body fat percentage in a large Korean population

Genetic Association of FTO gene variants (rs17817449 T&gt;G and rs9939609 T&gt;A) with obesity and its related Phenotypes in North Indian Punjabi Population

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Genetic Association of FTO gene variants (rs17817449 T>G and rs9939609 T>A) with obesity and its related Phenotypes in North Indian Punjabi Population