Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality

Amoako, Akwasi; Marczylo, Timothy H.; Elson, J.; Taylor, Anthony H.; Willets, Jonathon M.; Konje, Justin C.

doi:10.1016/j.fertnstert.2014.07.767

Cited by 14 publications

(13 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the male side, it should be recalled that nearly 1 in 6 couples suffers from infertility, with male factors accounting for 50% of cases [134]. Although anatomical factors explain a significant number of these, several of them remain unexplained, primarily because factors that are involved in the modulation of spermatogenesis and sperm function are poorly understood.…”

Section: Reproductive Systemmentioning

confidence: 99%

“…Quantification of eCB levels in seminal plasma from an infertility clinics showed AEA, PEA and OEA levels to be significantly lower in men with either asthenozoospermia or oligoasthenozoospermia, compared to normozoospemia [134, 136], and furthermore that supraphysiological levels of methanandamide (a non-hydrolyzable analogue of AEA) decreased sperm motility and viability through CB 1 -mediated inhibition of mitochondrial activity. Furthermore, PEA and OEA were shown to improve in vitro sperm motility and maintain viability without affecting mitochondrial activity [134].…”

Section: Reproductive Systemmentioning

confidence: 99%

“…Furthermore, PEA and OEA were shown to improve in vitro sperm motility and maintain viability without affecting mitochondrial activity [134]. Taken together, these findings suggest the maintenance of a normal eCB tone is most likely to be necessary for the preservation of normal sperm function, and hence of male fertility.…”

Section: Reproductive Systemmentioning

confidence: 99%

“…Taken together, these findings suggest the maintenance of a normal eCB tone is most likely to be necessary for the preservation of normal sperm function, and hence of male fertility. There is indeed some evidence that PEA and OEA, which possess anti-inflammatory, antimicrobial and antioxidant activities, may protect sperm from oxidative damage, inflammation and microbial infections [134]. In men with idiopathic infertility it has been shown that supplementation with PEA and OEA enhances sperm antioxidant activity, and consequently improves sperm kinematics parameters and hyperactivation in vitro .…”

Section: Reproductive Systemmentioning

confidence: 99%

See 3 more Smart Citations

Endocannabinoid signaling at the periphery: 50 years after THC

Maccarrone

Bab

Bı́ró

et al. 2015

Trends in Pharmacological Sciences

572

549

View full text Add to dashboard Cite

Fifty years ago (in 1964) the psychoactive ingredient of Cannabis sativa, Δ9-tetrahydrocannabinol (THC), was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed endocannabinoids (eCBs), were discovered: N-arachidonoylethanolamine (anandamide, AEA) in 1992, and 2-arachidonoylglycerol (2-AG) in 1995. Since then, considerable research has shed light on the impact of eCBs on human health and disease, identifying an ensemble of proteins that bind, synthesize and degrade them, and that altogether form the eCB system. eCBs control basic biological processes, including cell-choice between survival and death, and progenitor/stem cell proliferation and differentiation. Not surprisingly, in the past two decades, eCBs have been recognized as key mediators of several aspects of human pathophysiology, and thus have emerged among the most widespread and versatile signaling molecules ever discovered. Here, some of the pioneers of this research field review the state-of-the-art of critical eCB functions in peripheral organs. Our community effort is aimed at establishing consensus views on the relevance of the peripheral eCB system for human health and disease pathogenesis, as well as to highlight emerging challenges and therapeutic hopes.

show abstract

Section: Reproductive Systemmentioning

confidence: 99%

Section: Reproductive Systemmentioning

confidence: 99%

Section: Reproductive Systemmentioning

confidence: 99%

Section: Reproductive Systemmentioning

confidence: 99%

See 2 more Smart Citations

Endocannabinoid signaling at the periphery: 50 years after THC

Maccarrone

Bab

Bı́ró

et al. 2015

Trends in Pharmacological Sciences

572

549

View full text Add to dashboard Cite

show abstract

“…Men with either asthenozoospermia or oligoasthenozoospermia, two major causes of infertility, exhibit very low levels of AEA, but also of PEA and OEA, which in vitro improve sperm motility without affecting mitochondrial activity (17). They may protect sperm from oxidative damage, a possible cause of male infertility (15).…”

Section: Reproductive Systemmentioning

confidence: 99%

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Ligresti¹,

Petrocellis²,

Marzo³

2016

Physiological Reviews

378

337

View full text Add to dashboard Cite

Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis plant and its most peculiar chemical components, the plant cannabinoids (phytocannabinoids), have the merit to have led humanity to discover one of the most intriguing and pleiotropic endogenous signaling systems, the endocannabinoid system (ECS). This review article aims to describe and critically discuss, in the most comprehensive possible manner, the multifaceted aspects of 1) the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one ⌬ 9 -tetrahydrocannabinol, and 2) the adaptive prohomeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs. In doing so, we have respected the chronological order of the milestones of the millennial route from medicinal/recreational cannabis to the ECS and beyond, as it is now clear that some of the early steps in this long path, which were originally neglected, are becoming important again. The emerging picture is rather complex, but still supports the belief that more important discoveries on human physiology, and new therapies, might come in the future from new knowledge in this field.

show abstract

Endocannabinoids

2015

Handbook of Experimental Pharmacology

View full text Add to dashboard Cite

Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality

Cited by 14 publications

References 49 publications

Endocannabinoid signaling at the periphery: 50 years after THC

Endocannabinoid signaling at the periphery: 50 years after THC

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Endocannabinoids

Contact Info

Product

Resources

About