Relationship Between Serum Hepcidin and Ferritin Levels in Patients With Thalassemia Major and Intermedia in Southern Iran

Haghpanah, Sezaneh; Esmaeilzadeh, Masoomeh; Honar, Naser; Hassani, Fatemeh; Dehbozorgian, Javad; Rezaei, Narges; Abdollahi, Maryam; Bardestani, Marzieh; Safaei, Sanaz; Karimi, Mehran

doi:10.5812/ircmj.17(5)2015.28343

Cited by 27 publications

(30 citation statements)

References 24 publications

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“…However, we did not observe any significant difference between b-TM and b-TI patients as reported by others previously (19). This discrepancy may be due to the significant difference in age between the b-TM and b-TI groups and/or the clinical severity of irregularly chelated b-TI patients, and likely also due to the small number of studied patients.…”

Section: Discussioncontrasting

confidence: 82%

Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients

et al. 2014

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β-Thalassemia (β-thal) is a genetic disorder, representing a major health problem in Algeria. It is associated with altered lipid levels and a state of oxidative stress that can lead to cardiac complications and premature death. We examined the plasma lipid profile and redox status of 46 patients with β-thal major (β-TM) and β-thal intermedia (β-TI) compared to 36 healthy subjects. Plasma lipids including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were investigated. Oxidative status was evaluated by measuring malondialdehyde (MDA), reduced glutathione (GSH) and catalase (CAT) activity. The potential relationships between these parameters and the hemoglobin (Hb) blood concentrations, serum ferritin, duration and frequency of transfusion, splenectomy as well as age, were examined. Our data indicated that the study patients were under increased state of oxidative stress associated with hypertriglyceridemia, and hypocholesterolemia. The CAT activity was negatively correlated with Hb concentration and LDL-C/TG ratio and positively with years of transfusion. The elevated TC/HDL-C ratio particularly in β-TM patients who were younger, correlated positively with ferritinemia and triglyceride levels and suggested an increased coronary risk. This heightened risk state should lead to the inclusion of this index (TC/HDL-C) in clinical management, particularly in splenectomized patients.

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Section: Discussioncontrasting

confidence: 82%

Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients

et al. 2014

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“…We found that serum ferritin, the primary storage molecule for cellular iron, positively correlated with hepcidin in our CKD patients as previously documented among patients with CKD and those on dialysis (24,27,(31)(32)(33). This nding is also consistent with studies in non-CKD populations (34)(35)(36). In the setting of CKD, the direct relationship of hepcidin with ferritin may represent a protective effect of hepcidin against systemic iron overload (25).…”

Section: Discussionsupporting

confidence: 91%

Hepcidin and GDF-15 are potential biomarkers of Iron Deficiency Anaemia in Chronic Kidney Disease Patients in South Africa

Nalado

Olorunfemi

Dix-Peek

et al. 2020

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Background Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and it is associated with poor clinical outcomes and quality of life. It is not clear if growth differentiation factor-15 (GDF-15) or hepcidin are useful as early markers of iron deficiency anaemia (IDA) among non-dialysis CKD patients. We therefore evaluated the diagnostic validity of GDF-15 and hepcidin as biomarkers of IDA among non-dialysis CKD patients in Johannesburg, South Africa. Method An analytic cross-sectional study was conducted among non-dialysis CKD patients (n=312) and apparently healthy controls (n=184) from June to December 2016 at an Academic Hospital, in Johannesburg, South Africa. An interviewer administered proforma was used to obtain the Socio-biological and clinical characteristics of the participants. Serum levels of GDF-15 and hepcidin were determined Predictive logistic regression models were built and post estimation receiver operator characteristics was determined to evaluate diagnostic validity of hepcidin and GDF-15 for absolute and functional iron deficiency anaemia. Results About half (50.6%) of the participants were female while the participants’ mean age was 49.7 ±15.8 years. The predictive value of diagnosing absolute IDA among CKD patients using GDF-15 was 74.02% (95% CI: 67.62% - 80.42%) while the predictive value of diagnosing functional IDA among CKD patients using hepcidin was 70.1% (95% CI: 62.79% - 77.49%).There was a weak negative correlation between hepcidin levels and GFR (r=-0.19, p=0.04) in anaemic CKD patients, and between serum GDF-15 and haemoglobin (r=-0.34, p=0.001). Serum ferritin (β=0.00389, P-value<0.001), was a predictor of log hepcidin. MCHC (β= -0.0220, P-value 0.005) and CKD stage (β=0.4761, P-value <0.001), race (β = 0.3429, P-value = 0.018) were predictors of log GDF-15. Both GDF-15 (adj OR: 1.0003, 95%CI: 1.0001 – 1.0005, P=0.017) and hepcidin (adj OR: 1.003, 95%CI: 1.0004 – 1.0055, P=0.023) were associated with iron deficiency anaemia after multiple linear regression modelling.Conclusion Serum GDF-15 is a potential biomarker of absolute IDA, while hepcidin levels can predict functional IDA among CKD patients.

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“…9 The increased level of serum ferritin level was statistically highly significant as compared to that of normal healthy children (control group) as evident by pvalue which is less than 0.0001 (p<0.0001). The results of present series of study resembles with findings of Haghpanah S et al 10 Given the high prevalence of vitamin D deficiency in the general population and the added burden of increased metabolic demands, chronic medical care, and iron overload, it is not surprising that vitamin D deficiency is quite common in thalassemia major patients. The results of mean serum vitamin D were in close collaboration with the results obtained by Wood JC et al…”

Section: Discussionsupporting

confidence: 89%

Comparative study of serum ferritin and vitamin D in thalassemia patients with healthy controls

2018

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Background: Thalassemia is the most common genetic disorder in humans; they are encountered among all ethnic groups and in almost every country around the world. Mostly occur in the regions surrounding the Mediterranean sea, hence the name. These are a group of hereditary haemolytic disorders characterized by impairment in the synthesis of globin chains of Hb. The present study aimed to find out the serum ferritin and vitamin D level in thalassemic children in the tertiary care hospital in Bikaner, western Rajasthan, India.Methods: In this study 50 (27 male and 23 female) adult skulls were investigated to determine the type of asterion, its distance from important bony landmarks and also the nearby venous sinuses were measured.Results: Level of serum ferritin was significantly high and vitamin D was significantly low (p-value<0.0001 for both) in thalassemic children.Conclusions: In this study the role of serum ferritin and vitamin D has been explored. The extremely high level of ferritin was found due to the regular blood transfusion and consequent iron overload and low vitamin D was found due to impairment in liver functions among thalassemic children.

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Relationship Between Serum Hepcidin and Ferritin Levels in Patients With Thalassemia Major and Intermedia in Southern Iran

Cited by 27 publications

References 24 publications

Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients

Oxidative Status and Plasma Lipid Profile in β-Thalassemia Patients

Hepcidin and GDF-15 are potential biomarkers of Iron Deficiency Anaemia in Chronic Kidney Disease Patients in South Africa

Comparative study of serum ferritin and vitamin D in thalassemia patients with healthy controls

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