Relationship between serum lactate dehydrogenase levels and prognosis in patients infected with omicron and delta variants of COVID-19: A cross-sectional study

Ostadi, Fatemeh; Anzali, Babak Choobi; Mehryar, Hamid Reza

doi:10.1016/j.toxrep.2023.10.003

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…The diagnostic and prognostic values of lactate in septic patients have been assessed in the setting of an emergency department, intensive care unit or in the trauma patient. High lactate is strongly associated with poor outcome and high mortality [ 29 ]. High lactate levels, associated with poor outcomes in our study, corroborate the existing literature on the subject and suggest that interventions aimed at improving lactate clearance could be beneficial in enhancing patient outcomes [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department

Trebuian,

Brici,

Sutoi

et al. 2024

Clinics and Practice

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Background: This investigation assesses the prognostic value of lactate levels and their clearance in septic shock patients, particularly emphasizing the comparative analysis between COVID-19 and non-COVID-19 patients in the emergency department. This study aims to elucidate the unique prognostic implications of lactate dynamics in these distinct patient groups, thereby enhancing the management of septic shock. Methods: An observational prospective study was conducted, enrolling 114 septic shock patients from the Emergency County Hospital Resita, Romania, categorizing them into COVID-19 and non-COVID-19 groups to examine their initial lactate levels, clearance rates, and their correlation with patient outcomes. Results: This study identified significant differences in the initial lactate levels and clearance rates between the two groups, indicating higher initial lactate levels and slower clearance rates in COVID-19 patients. Survivors demonstrated significantly lower initial lactate levels (1.5 ± 0.4 mmol/L) and higher lactate clearance rates (33 ± 15%) compared to non-survivors (2.5 ± 0.5 mmol/L and 24 ± 9%, respectively; lactate levels p = 0.001, clearance rates p = 0.002). Conclusions: Lactate monitoring, particularly clearance rates, is crucial in the prognostic assessment of septic shock patients. These findings highlight the need for targeted interventions in COVID-19 patients to improve outcomes, underscoring lactate dynamics as a vital component of septic shock management in differing patient populations.

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Section: Discussionmentioning

confidence: 99%

Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department

Trebuian,

Brici,

Sutoi

et al. 2024

Clinics and Practice

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Analysis of six consecutive waves of ICU-admitted COVID-19 patients: key findings and insights from a Portuguese population

Von Rekowski,

Pinto,

Fonseca

et al. 2024

GeroScience

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Identifying high-risk patients, particularly in intensive care units (ICUs), enhances treatment and reduces severe outcomes. Since the pandemic, numerous studies have examined COVID-19 patient profiles and factors linked to increased mortality. Despite six pandemic waves, to the best of our knowledge, there is no extensive comparative analysis of patients’ characteristics across these waves in Portugal. Thus, we aimed to analyze the demographic and clinical features of 1041 COVID-19 patients admitted to an ICU and their relationship with the different SARS-Cov-2 variants in Portugal. Additionally, we conducted an in-depth examination of factors contributing to early and late mortality by analyzing clinical data and laboratory results from the first 72 h of ICU admission. Our findings revealed a notable decline in ICU admissions due to COVID-19, with the highest mortality rates observed during the second and third waves. Furthermore, immunization could have significantly contributed to the reduction in the median age of ICU-admitted patients and the severity of their conditions. The factors contributing to early and late mortality differed. Age, wave number, D-dimers, and procalcitonin were independently associated with the risk of early death. As a measure of discriminative power for the derived multivariable model, an AUC of 0.825 (p < 0.001; 95% CI, 0.719–0.931) was obtained. For late mortality, a model incorporating age, wave number, hematologic cancer, C-reactive protein, lactate dehydrogenase, and platelet counts resulted in an AUC of 0.795 (p < 0.001; 95% CI, 0.759–0.831). These findings underscore the importance of conducting comprehensive analyses across pandemic waves to better understand the dynamics of COVID-19.

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Epidemiology, clinical spectrum, and outcomes of severe malaria in Eastern Uganda: a prospective study

Namayanja,

Paasi,

Alunyo

et al. 2024

Preprint

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Background In Sub-Saharan Africa, malaria remains a public health problem despite some reports of declining incidence in the period 2000–2018. Since 2019, there are some reports of disease epidemics, resurgences in areas that had registered steep decline and unusual clinical presentation. This study aimed to describe the epidemiology, clinical spectrum, and outcomes of severe malaria in children in malaria-endemic Eastern Uganda, a region that has recently experienced epidemics. Methodology: This prospective study was conducted at Mbale Regional Referral Hospital, Uganda, from May 08, 2019 to August 15, 2023 as part of the Malaria Epidemiological, Pathophysiological and Intervention studies in Highly Endemic Eastern Uganda (EDCTP - TMA2016SF-1514-MEPIE Study). Children aged 60 days to 12 years who at admission tested positive for malaria and fulfilled the clinical WHO criteria for surveillance of severe malaria were enrolled into the study following appropriate informed consent. Data were collected using a customised proforma on social demographic characteristics, clinical presentation, treatment, and outcomes. Laboratory analyses included complete blood counts, lactate, glucose, blood gases, electrolytes, metabolites, and coagulation markers. In addition, urinalysis using dipsticks was done. Data were analysed using STATA V15. The study had ethical and regulatory approval before data collection commenced. Results A total of 1,379 participants were recruited. The median age was 4 years. Most children 757/1379 (54.9%) were under 5 years, and 825/1379 (59.8%) were males. The common symptoms were fever 1368(99.2%), poor appetite 1095(79.5%), inability to sit upright 1051(76.2%), vomiting 944(68.4%) and yellow eyes 833(60.4%). The common signs included prostration, haemoglobinuria and jaundice. Prolonged hospitalization was found in 284/1339(21.2%) and was associated with impaired consciousness 116/166(30.1%), P = 0.003; haemoglobinuria 514/705 (27.1%), P < 0.001 and jaundice 505/690(26.8%) P < 0.001. The overall mortality was 40/1347 (3.0%). Children who had > 1 severity feature were at a higher risk of mortality. Conclusion In this prospective study in children with severe malaria in Eastern Uganda, the overall mortality was 3.0% and the more the disease clinical syndromes the higher the risk of death.

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Relationship between serum lactate dehydrogenase levels and prognosis in patients infected with omicron and delta variants of COVID-19: A cross-sectional study

Cited by 3 publications

References 19 publications

Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department

Lactate Levels and Clearance: Key Predictors of Prognosis for COVID-19 and Non-COVID-19 Septic Shock Patients in the Emergency Department

Analysis of six consecutive waves of ICU-admitted COVID-19 patients: key findings and insights from a Portuguese population

Epidemiology, clinical spectrum, and outcomes of severe malaria in Eastern Uganda: a prospective study

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