Relationship Between Serum Prostate-Specific Antigen Levels and Components of Metabolic Syndrome in Healthy Men

Han, June Hyun; Choi, Nak Young; Bang, Seong Hak; Kwon, Oh Jung; Jin, Young Woo; Myung, Soon Chul; Chang, In Ho; Kim, Tae Hyoung; Ahn, Seung Hyun

doi:10.1016/j.urology.2008.01.084

Cited by 37 publications

(39 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, most of the previous studies that examined the relationship of MS and PSA did not adjust prostate volume. [1][2][3][4][5][6] Interestingly, the PSA of men with MS was not higher than that without MS in those studies. mass (serum PSA 9 plasma volume) was used to adjust the plasma volume, and there were no significant differences of PSA mass between men with MS and without MS.…”

Section: Introductionmentioning

confidence: 73%

“…A PSA screening result also showed that serum PSA is significantly influenced by most components of MS including obesity, DBP, HDL and FBG. 2 Another study also proved MS was associated with decreased PSA level. 4 In that study, PSA of men with MS and without MS were 0.75 and 0.80 ng/mL (P = 0.043), and an increased number of MS components was significantly correlated with decreasing PSA levels (Ptrend <0.001).…”

Section: Discussionmentioning

confidence: 96%

“…Most studies reported that men with MS had lower PSA than men without MS. [1][2][3][4] Data from the National Health and Nutrition Examination Survey in [2001][2002][2003][2004] showed that the mean PSA of men with MS is slightly lower than of men without MS (0.98 ng/mL vs 0.87 ng/mL), although it was not statistical significant (P = 0.20).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

et al. 2016

View full text Add to dashboard Cite

Abbreviations & Acronyms ALT = alanine transaminase AST = aspartate aminotransferase BMI = body mass index BPH = benign prostatic hyperplasia BSA = body surface area Cr = serum creatinine DBP = diastolic blood pressure FBG = fasting blood glucose HDL = high-density lipoprotein LUTS = lower urinary tract symptom MS = metabolic syndrome PSA = prostate-specific antigen SBP = systolic blood pressure TRUS = transrectal ultrasonography Objectives: To investigate the influence of metabolic syndrome on prostate-specific antigen levels by considering prostate volume and plasma volume. Methods: We retrospectively analyzed 4111 men who underwent routine check-ups including prostate-specific antigen and transrectal ultrasonography. The definition of metabolic syndrome was based on the modified Adult Treatment Panel III criteria. Prostate-specific antigen mass density (prostate-specific antigen 9 plasma volume / prostate volume) was calculated for adjusting plasma volume and prostate volume. We compared prostate-specific antigen and prostate-specific antigen mass density levels of participants with metabolic syndrome (metabolic syndrome group, n = 1242) and without metabolic syndrome (non-prostate-specific antigen metabolic syndrome group, n = 2869). To evaluate the impact of metabolic syndrome on prostate-specific antigen, linear regression analysis for the natural logarithm of prostate-specific antigen was used. Results: Patients in the metabolic syndrome group had significantly older age (P < 0.001), larger prostate volume (P < 0.001), higher plasma volume (P < 0.001) and lower mean serum prostate-specific antigen (non-metabolic syndrome group vs metabolic syndrome group; 1.22 AE 0.91 vs 1.15 AE 0.76 ng/mL, P = 0.006). Prostate-specific antigen mass density in the metabolic syndrome group was still significantly lower than that in the metabolic syndrome group (0.124 AE 0.084 vs 0.115 AE 0.071 lg/mL, P = 0.001). After adjusting for age, prostate volume and plasma volume using linear regression model, the presence of metabolic syndrome was a significant independent factor for lower prostatespecific antigen (prostate-specific antigen decrease by 4.1%, P = 0.046). Conclusions: Prostate-specific antigen levels in patients with metabolic syndrome seem to be lower, and this finding might be affected by the prostate volume.

show abstract

Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

et al. 2016

View full text Add to dashboard Cite

show abstract

“…[36,37] Increases in the levels of estradiol, and sex hormone-binding globulin and sex hormone-binding globulin, and decreased free testosterone levels have been indicated to be effective on this process. [38,39] Endocrine disruptors are substances which disrupts synthesis, secretions, effects, elimination of naturally existing hormones in human beings, and their binding to receptors including drugs, pesticides, plastic additives, organic contaminants. Most of them are xenoestrogens or antiandrogens.…”

Section: Prostate Cancermentioning

confidence: 99%

Metabesity and urological cancers

Atan

2017

Turkish Journal of Urology

View full text Add to dashboard Cite

Metabolic syndrome is one of today's most important health problems. Due to increased prevalence of metabolic syndrome in society, studies done on this topic have increased in number. Although metabolic syndrome was previously considered to be important only for cardiovascular health, it has been learned that with new data, human health is compromised more thoroughly by metabolic syndrome and is also a danger to malignancy. As a result, a new definition in the form of metabesity has been introduced. In this review, available information on metabesity and urological cancers is presented.

show abstract

“…Metabolic syndrome is a constellation of risk factors that is associated with cardiovascular disease and npg some clusters of these components were known to have an effect on serum prostate-specific antigen (PSA) concentration in healthy men [5]. Body mass index (BMI) among these components was known to influence serum PSA level the most and to be negatively correlated with serum PSA concentration [6,7], even though there was a controversy regarding which one would affect serum PSA concentration between hemodilution according to increasing plasma volume in obese men and androgen metabolism based on aromatase and sex hormone-binding globulin [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men

Han¹,

Lee²,

Kwak³

et al. 2010

Asian J Androl

Self Cite

View full text Add to dashboard Cite

The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen (PSA) levels in healthy men with serum PSA level below 4 ng mL -1 . The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment (HOMA [fasting glucose × fasting insulin]/22.5) and quantitative insulin sensitivity check index (QUICKI; 1/[log (fasting insulin) + log (fasting glucose)]). Age-adjusted body mass index (BMI) was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance (ANOVA) test and Duncan's multiple comparison test (P < 0.001), but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI (P < 0.001). Age, BMI, insulin resistance by HOMA or QUICKI were significantly independent variables to serum PSA level in a multivariate linear regression analysis (P < 0.001). Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.

show abstract

Relationship Between Serum Prostate-Specific Antigen Levels and Components of Metabolic Syndrome in Healthy Men

Cited by 37 publications

References 33 publications

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

Prostate‐specific antigen lowering effect of metabolic syndrome is influenced by prostate volume

Metabesity and urological cancers

Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men

Contact Info

Product

Resources

About