Relationship between Serum Testosterone and Fracture Risk in Men: A Comparison of RIA and LC-MS/MS

Tran, Thach; Seibel, Markus J.; Eisman, John A.; Kushnir, Mark M.; Rockwood, Alan L.; Nguyen, Tuan V.

doi:10.1373/clinchem.2015.242339

Cited by 13 publications

(12 citation statements)

References 35 publications

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“…[ 22 , 23 ] Multiple studies have shown a significant decrease in bone density and an increased risk of brittle fractures in patients with low testosterone levels. [ 24 , 25 ] In addition, patients with prostate cancer who undergo androgen deprivation therapy or orchiectomy also experience decreased bone density and increased risk of fracture. [ 26 , 27 ] There is also a link between the testosterone and vitamin D pathway.…”

Section: Discussionmentioning

confidence: 99%

Risk of osteoporosis in patients with erectile dysfunction

Wang

Zhang

et al. 2021

Medicine

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Background: Erectile dysfunction (ED) and osteoporosis are both common health problems and have similar risk factors. Recent studies have found that people with ED have a higher risk of osteoporosis. We aimed to systematically assess osteoporosis risk in patients with ED. Methods: A systematically research was carried out in Medline via PubMed, Cochrane Library, EMBASE, and Web of Science up to June 4, 2020, to identify articles related to ED and osteoporosis. The 2 researchers independently reviewed the literature, extracted the data, and evaluated the quality of the literature. All analyses were done using RevMan5.3 and Stata14. Results: A total of 4 studies involving 22,312 participants were included. The meta-analysis results showed that the risk of osteoporosis in the ED group was significantly higher than that in the non-ED group [odds ratio (OR) = 2.66, 95% confidence interval (95% CI) 1.42 to 4.98, P = .002, I 2 = 68%]. Interestingly, compared with older participants, the increased risk of osteoporosis in ED patients seemed to be more pronounced in younger participants. Despite the lack of data for meta-analysis, more than half of the literature mentioned this tendency. We found the source of heterogeneity through sensitivity analysis, and there was no significant effect on the results before and after the removal of this literature, indicating that our results were robust. No obvious publication bias was found through Egger method ( P = .672). Conclusion: People with ED have a higher risk of osteoporosis, especially among younger males. Because the assessment of osteoporosis is economical and noninvasive, ED patients should be evaluated by bone mineral density or men with osteoporosis should be further assessed for erectile function.

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Section: Discussionmentioning

confidence: 99%

Risk of osteoporosis in patients with erectile dysfunction

Wang

Zhang

et al. 2021

Medicine

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“…There was also evidence of a nonlinear association between androstenedione and percent-water; relative to women in the lowest quartile those in the second lowest had a 4% (0.96; 0.87-1.06) lower percent-water while those in the second and first highest quartiles had, respectively, a 2% (1.02; 0.92-1.13) and 1% (1.01; 0.92-1.12) higher percent-water ( Supplementary Table S3). Plasma testosterone levels at age 15.5 were weakly correlated with levels at age 21.5 (r ¼ 0.45; P < 0.001) despite the different measurement methodologies used (30). Neither adolescent nor young adult testosterone levels were found to be associated with MRI breast measures.…”

Section: Plasma Sex Hormones and Mri Breast Measuresmentioning

confidence: 93%

Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women

Denholm

Stavola

Hipwell³

et al. 2018

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“… 11 Other studies have found a concordance between LC/MS and RIA in the measurement of total testosterone. 13 In a study on 56 men (aged 26–77 years) comparing RIA and EqD, a robust correlation ( r = 0.966) in results was observed, 14 but as this study was performed with samples from normal, healthy men, the measurements were not at the lower end of the concentration spectrum where assay differences, if they exist, may be expected to occur.…”

Section: Resultsmentioning

confidence: 82%

How do we define “castration” in men on androgen deprivation therapy?

Itty

Getzenberg

2020

Asian J Androl

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Androgen deprivation therapy (ADT) is the mainstay for the treatment of advanced prostate cancer. Since the clinical evolution from surgical orchiectomy, we have typically used ADT and orchiectomy to be synonymous terms for castration. The goal of this study is to determine if, in contemporary medical practice, surgical and chemical castration provide for similar levels of diminishment of total and free testosterone. Further, what approaches should be used to most accurately measure testosterone levels in men with advanced prostate cancer and what cutoff values, for example for total testosterone 50 ng dl −1 or 20 ng dl −1 , should be utilized. Studies available in the literature have been analyzed and compiled to address these questions. Finally, evidence is provided that free testosterone, the biologically active component, should be utilized to provide clinically relevant state of castration.

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Relationship between Serum Testosterone and Fracture Risk in Men: A Comparison of RIA and LC-MS/MS

Abstract: BACKGROUND: Serum testosterone can be measured by LC-MS/MS and RIA. We investigated whether the testosterone-fracture relationship was affected by the method of measurement.

Cited by 13 publications

References 35 publications

Risk of osteoporosis in patients with erectile dysfunction

Risk of osteoporosis in patients with erectile dysfunction

Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women

How do we define “castration” in men on androgen deprivation therapy?

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