Relationship between serum uric acid level and vascular injury markers in hemodialysis patients

Harada, Makoto; Fujii, Kazuaki; Yamada, Yosuke; Tsukada, Wataru; Tsukada, Manabu; Hashimoto, Koji; Kamijo, Yuji

doi:10.1007/s11255-020-02531-w

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Carotid intima-media thickness is associated with the degree of coronary atherosclerosis and the outcome of ischaemic stroke and has been used as an alternative marker for cardiovascular and cerebrovascular diseases in clinical trials and observational studies [34][35][36][37]. The…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress is the key link in endothelial dysfunction caused by hyperuricaemia and is related to the increased risk of cardiovascular and cerebrovascular disease [38]. Because uric acid is generally considered to have more harmful than protective effects, it is considered to be a risk factor for CIMT and atherosclerosis [35,36,33], but the clinical relevance of the two has been controversial. Since 1950, research on the relationship between serum uric acid level and carotid intima-media thickness has attracted scholars' attention [39].…”

Section: Plos Onementioning

confidence: 99%

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Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Wang

Huang

et al. 2021

PLoS ONE

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Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for statistical analysis. The standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated by a random effect model to estimate the correlation. Publication bias was assessed using the Begg and Egger tests. The stability of these results was evaluated using sensitivity analyses. Results Fifteen studies were included with a total sample size of 11382, including 7597 participants in the high uric acid group and 3785 in the control group, on the basis of the inclusion and exclusion criteria. According to the evaluation of the JBI scale, the literature was of high quality. The average age ranged from 42 to 74. Meta-analysis showed that CIMT in the high uric acid group was significantly higher than that in the control group (SMD = 0.53, 95% CI: [0.38, 0.68]), and the difference was significant (z = 6.98, P < 0.00001). The heterogeneity among the 15 articles was obvious (I2 = 89%, P < 0.00001). Subgroup analysis by disease status illustrated a positive relationship between SUA and CIMT in healthy people and people with diseases. SUA was shown to be positively correlated with CIMT in people aged 45–60 years and ≥60 years by subgroup analysis by age. SUA was also found to be positively correlated with CIMT in a population with BMI>24 kg/m2 by subgroup analysis by BMI. In addition, subgroup analysis of other risk factors for CIMT, including TC, SBP, DBP, triglycerides, and LDL-C, all showed a positive correlation between SUA and CIMT. Conclusions There is a significant correlation between serum uric acid level and carotid intima-media thickness, and a high concentration of serum uric acid is related to carotid artery intima-media thickness.

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Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Wang

Huang

et al. 2021

PLoS ONE

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“…Interestingly, they found an inverse correlation between these two parameters. 44 The increase in arterial stiffness measured by CAVI is a marker of deterioration in renal function. 45 The use of intravenous contrast agents in imaging can lead to acute deterioration in renal function.…”

Section: Cardio Ankle-vascular Index and Renal Functionmentioning

confidence: 99%

Possible Clinical Benefits of Cardio-Ankle Vascular Index Measurement in Urological Diseases

Bülbül¹,

Ozilhan²,

Sezer³

et al. 2023

VHRM

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Many factors are considered to affect vascular physiology. It is known that one of the reasons for many diseases is a pathology at the microvascular level. Therefore, the relationship between endothelial dysfunction and many diseases is currently being investigated. The clinical evaluations of arterial stiffness have made it possible to perform necessary risk assessment regarding cardiovascular diseases. In this way, protective measures can be taken against microvascular pathologies in many organs. In this paper, we present a review of studies investigating the relationship between urological conditions and the cardio-ankle vascular index (CAVI), a marker of arterial stiffness. As with erectile dysfunction, some studies have shown that conditions such as lower urinary tract symptoms, overactive bladder, and chronic kidney disease are also associated with an elevated CAVI. The association of erectile dysfunction and chronic kidney disease with vascular pathologies has been clearly demonstrated. In addition, lower urinary tract symptoms may be the first sign of silent vascular dysfunction. Assessing arterial stiffness with CAVI can help prevent future cardiovascular events in these patients.

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“…high altitude will further damage vascular endothelium and lead to metabolic disorders. Plateau environment with acute hypoxia may causes extensive renal hypoxia stress, mainly damaging glomerular endothelial cells and renal tubular epithelial cells, which cannot be recovered through reoxygenation [16] . In our research, SCR in HUA group fluctuated within normal ranges, but the multivariate regression analysis showed that SCR was an independent risk factor for HUA.…”

Section: Univariate and Multivariate Logistic Regression Analysismentioning

confidence: 99%

Study of the incidence of hyperuricemia in young males’ population with rapid entry into the plateau of 4 500m

Liu

Hong

et al. 2022

Frigid Zone Medicine

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Objective To study the incidence and risk factors of hyperuricemia in young males who rapid entered into the plateau of 4 500 m. Methods The study contained 390 males aged 18–35 years (21.6 ± 2.5 years), who rapidly entered the plateau with an altitude of 4 500 m. According to their basic level of uric acid (UA), they were divided into two groups, high uric acid (HUA) group and normal uric acid (NUA) group. The characteristics and physiological index, such as the body weight and the height, of them were recorded. For the test of the biochemical indicators, the venous blood samples were collected at the altitude of 4 500 m in the morning. The count of blood cells, blood urea nitrogen (BUN), serum creatinine (SCR), lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IDBIL) were compared between the two groups. Results The incidence of hyperuricemia was 65.1% (254/390) at 4 500 m. At the altitude of 4 500 m, the mean hemoglobin concentration (MCHC) of red blood cells in the HUA group was significantly lower than that in the NUA group. Hemoglobin (HGB), mean red blood cell volume (MCV), TBIL, IDBIL, BUN, SCR and LDH in the HUA group were significantly higher than those in the NUA group, though without statistically significant differences in the other variables. Meanwhile, multivariate analysis showed at the altitude of 4 500 m, the risk of HUA increased by 0.982, 1.038 and 1.045 times when MCHC decreased by one unit and TBIL and SCR increased by one unit, respectively. Conclusion The incidence of hyperuricemia was high of 65.1% rush entry into the plateau of young male. Decreased MCHC and elevated TBIL and SCR were independent risk factors for hyperuricemia when rapid enter into 4 500 m.

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Relationship between serum uric acid level and vascular injury markers in hemodialysis patients

Cited by 9 publications

References 41 publications

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Possible Clinical Benefits of Cardio-Ankle Vascular Index Measurement in Urological Diseases

Study of the incidence of hyperuricemia in young males’ population with rapid entry into the plateau of 4 500m

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