Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study

Abstract

BackgroundThe impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women.MethodsThree hundred and thirty eight patients (207 women and 131 men) were cross-sectionally evaluated by clinical, laboratory, hemodynamic and carotid ultrasound analysis. Common carotid diameters, circumferential wall tensions, Young’s Elastic Modulus, Stiffness Index, Arterial Compliance and intima-media thickness (IMT) were determined. Internal carotid artery resistive index (ICRI), a hemodynamic measure that reflects local vascular impedance and microangiopathy, was also assessed.ResultsUnivariate analysis showed no significant correlation of SUA with carotid diameters, elasticity/stiffness indexes, IMT and circumferential wall tensions in both genders. Conversely, SUA correlated with ICRI (r = 0.34; p < 0.001) in women, but not in men, and hyperuricemic women presented higher ICRI than normouricemic ones (0.684 ± 0.007 vs. 0.649 ± 0.004; p < 0.001). Stepwise and logistic regression analyses adjusted for potential confounding factors showed that ICRI was independently associated with SUA and hyperuricemia in women.ConclusionsThis study demonstrated that SUA was associated with ICRI in hypertensive women, suggesting that there might gender-related differences in the relationship between SUA and vascular damage in subjects with systemic hypertension.

Association between serum uric acid, aortic, carotid and femoral stiffness among adults aged 40–75 years without and with type 2 diabetes mellitus

“…In the present study, we found no difference in the associations between uric acid and femoral stiffness or carotid stiffness. In line with our study, Cipolli et al [29] did not identify an association between uric acid and carotid YEM or carotid compliance coefficient in 338 individuals with hypertension. In addition, an association between uric acid and carotid distensibility coefficient was not found among young adults [30].…”

“…Studies that investigated the relation between uric acid and local arterial stiffness indices are scarce [29,30]. However, assessing local carotid stiffness indices may be of importance [6].…”

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

“…The Atherosclerosis Risk in Communities (ARIC) Study also found a correlation between the uric acid level and an elevated CIMT in men; however, that correlation was not independent of the use of diuretics 34) . In contrast, no association between the serum uric acid level and carotid atherosclerosis was observed in the Korean Multi-Rural Communities Cohort study or a cohort of hypertensive women 35,36) ; these study participants were restricted to specific populations of rural areas or females patients with hypertension. Hence, data for the general population are scare, especially in Chinese populations.…”

Ultrasonographic measurement of carotid artery resistive index and diastolic function of the heart in gout patients

“…In the literature, we have found that Cipolli et al examined cross-sectionally 338 hypertensive patients (207 women and 131 men) and showed that internal carotid artery resistive index was independently associated with hyperuricemia in women. In their study, patients who had suffered a gout attack were not included [25]. In contrast, we estimated that gouty tophi increased the patients' likelihood of having abnormal value of CCARI twice than arterial hypertension, as hyperuricemia did not appreciably modify the odds of having abnormal value of CCARI.…”