Relationship between serum vitamin D and thyroid hormone profiles in male patients with alcohol dependence

Liu, Yu; Xu, Yayun; Wang, Yongmei; Pang, Liangjun; Zhang, Xulai

doi:10.1186/s12888-023-05274-x

Cited by 1 publication

(1 citation statement)

References 21 publications

(18 reference statements)

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“…In this study, the prevalence of vitamin D deficiency was greater than the prevalence found in other series of treatment-seeking patients with AUD, as studies from Asia and Northern and Central Europe reported a prevalence ranging from 60% and 75% [ 18 , 19 , 20 , 21 , 22 ]. A recent Spanish study among patients with severe AUD admitted to an internal medicine ward in the Canary Islands reported a prevalence of vitamin D deficiency of 28% [ 23 ].…”

Section: Discussioncontrasting

confidence: 49%

Vitamin D Deficiency Is Associated with Advanced Liver Fibrosis and Impaired Fasting Glucose in Alcohol Use Disorder

Zuluaga,

Casado-Carbajo,

Hernández-Rubio

et al. 2024

Nutrients

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Background: Vitamin D deficiency is a risk factor for liver disease, insulin resistance, and beta cell dysfunction. Individuals with alcohol use disorder (AUD) have many comorbidities, with a heavy burden of liver disease and metabolic complications, including type 2 diabetes mellitus (T2DM). Objective: We aimed to analyze the prevalence and associations of vitamin D deficiency in patients admitted for in-hospital treatment of AUD. Methods: A cross-sectional study was conducted in patients consecutively admitted for the treatment of AUD between January 2017 and October 2023. Sociodemographic data, substance use characteristics, and blood parameters were available at admission. Vitamin D status was assessed through the serum concentrations of 25-hydroxyvitamin D [25(OH)D] levels using a direct competitive chemiluminescent immunoassay method. Deficiency of vitamin D was defined as a concentration less than 20 ng/mL; impaired fasting glucose (IFG) was defined by fasting blood glucose >100 mg/dL (5.6 mmol/L), and advanced liver fibrosis by an FIB-4 index >3.25. Results: Two hundred and forty-three patients were included (75% male) with a mean age of 49 ± 10 years, mean BMI of 26.4 ± 7.3, mean alcohol consumption of 163 ± 81 g/day, and a mean duration of AUD of 18.1 ± 11.2 years. Mean 25(OH)D, fasting blood glucose, AST, ALT, and platelets were 14.4 ± 10.2 ng/mL, 103.4 ± 40.9 mg/dL, 55.1 ± 75.8 U/L, 44.8 ± 76.6 U/L, and 206.3 ± 84.8 × 109/L, respectively. The prevalence of vitamin D deficiency was 80.6%, and 41.1% of patients had levels less than 10 ng/mL. IFG was present in 32.3% of patients, and 20.5% had FIB-4 values >3.25. In the multivariable analysis, IFG (OR, 2.51; 95% CI: 1.02–6.17, p = 0.04) and advanced liver fibrosis (OR, 4.27; 95% CI: 1.21–15.0, p = 0.02) were the only factors associated with vitamin D deficiency. Conclusions: Vitamin D deficiency was very prevalent in this series of patients with AUD and was associated with impaired fasting glucose and advanced liver fibrosis.

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