Relationship Between Skeletal Mass Index and Different Obesity Metabolic Phenotypes Among Adolescents in China

Abstract

Objective: To explore the relationship between skeletal mass index (SMI) and different obesity metabolic phenotypes among adolescents,and to provide a theoretical basis for the prevention and control of obesity and related metabolic diseases in adolescents. Design and method: A total of 1352 adolescents aged 12-18 were randomly selected for questionnaire survey,physical measurements,body composition determination and laboratory testing. Multiple logistic regression analysis was used to analyze the correlation intensity between SMI and different metabolic phenotypes of obesity. Results: The metabolically unhealthy normal weight (MUNW) phenotype, metabolically healthy obesity(MHO) phenotype and metabolically unhealthy obesity(MUO) phenotype had lower levels of SMI compared to the metabolically healthy normal weight(MHNW) phenotype among adolescents,with all differences being statistically significant(P-values were all less than 0.001). Similar results were found after stratification by sex. Multiple logistic regression analysis showed that after adjusting for sex, SMI were protective factors for MUNW phenotype, MHO phenotype and MUO phenotype in adolescents(P-values were all less than 0.001),with the 0.86(95%CI:0.85,0.92),0.78(0.75,0.82) and 0.73(0.70,0.76) increased risks of MUNW phenotype, MHO phenotype and MUO phenotype associated with each unit rise in SMI, similar results were found after stratification by sex. Conclusions: SMI were protective factors for MUNW phenotype, MHO phenotype and MUO phenotype among adolescents. Attention should be paid to the assessment and supervision of adolescent skeletal muscle quality when prevented obesity and related metabolic risks,reducing the risk of abnormal cardiovascular metabolism in adolescents.

Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition

“…For sarcopenia, the results are mixed, although sarcopenia is associated with worse metabolic health [35]. On one hand, there may not be a protective effect of MHO, as the skeletal muscle index was not significantly higher compared to the MHO group [36]. Conversely, the prevalence of sarcopenia was significantly lower in the MHO group compared to the MUO group [37].…”