Relationship between Sleep Stage IV Deficit and Reversible HGH Deficiency in Psychosocial Dwarfism

Guilhaume, A; Benoît, O; Gourmelen, M; Richardet, J. M.

doi:10.1203/00006450-198204000-00011

Cited by 47 publications

(21 citation statements)

References 8 publications

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“…The report by Orr et al [10] showed that children (6-16 years) with GH deficiency had no deviation of delta sleep compared to controls. Guilhaume et al [11] on the contrary demonstrated a relationship between stage IV sleep and reversible GH deficiency in 4 chil dren aged 1-3 years. These children had psychosocial dwarfism and initially almost absent stage 4 sleep, but after a growth re covery period the stage IV sleep increased.…”

Section: Discussionmentioning

confidence: 99%

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Growth Hormone-Deficient Young Adults Have Decreased Deep Sleep

Åström

Lindholm²

1990

Neuroendocrinology

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The sleep in young adults with severe isolated growth hormone deficiency (IGHD) was examined by polysomnography. There was a significant decrease in delta sleep time (= stages 3 + 4, slow wave sleep, ‘deep sleep’), especially in stage 4. The total sleep time was significantly increased compared to age- and sex-matched normal subjects. The increase in total sleep time was related to an increase in stage 1 and stage 2 sleep. There was no significant difference in total rapid eye movement (REM) sleep time, but when correcting for the very long sleep time in the IGHD subjects, the cumulated REM time within the first 390 min of sleep was significantly less than in the normal subjects.

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Section: Discussionmentioning

confidence: 99%

“…Few studies have been carried out on GH deficiency and sleep and exclusively in children [10][11][12]. The report by Orr et al [10] showed that children (6-16 years) with GH deficiency had no deviation of delta sleep compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone-Deficient Young Adults Have Decreased Deep Sleep

Åström

Lindholm²

1990

Neuroendocrinology

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“…Nestas crianças a secreção do hormônio sobe rapidamente na fase de sono com ondas lentas 17,18 . Acredita-se que uma ruptura na arquitetura do sono das crianças, decorrente dos despertares freqüentes em conseqüência à apnéia ocorre, principalmente, na fase de sono com ondas lentas, sendo o mecanismo responsável pela redução da secreção do GH 19 . O tratamento da apnéia do sono levaria a uma reversibilidade desta situação 1 , favorecendo o crescimento normal das crianças após a adenoamigdalectomia.…”

Section: Discussionunclassified

Crescimento pôndero-estatural de crianças após adenoamigdalectomia

Francesco

Junqueira

Frizzarini

et al. 2003

Rev. Bras. Otorrinolaringol.

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A hiperplasia adenoamigdaliana é a principal causa de obstrução das vias aéreas superiores em crianças, sendo muitas vezes associada à apnéia do sono. Esta, por sua vez, resulta em uma série de comprometimentos: baixo rendimento escolar, cor pulmonale, distúrbios de comportamento não específicos, hiperatividade, sonolência diurna, distração e atrasos de desenvolvimento, sendo o déficit pôndero-estatural o mais grave. A adenoamigdalectomia é o tratamento de escolha. O objetivo deste trabalho é mensurar o crescimento e desenvolvimento das crianças antes e depois da adenoamigdalectomia através da comparação dos percentis pré e pós operatórios. Forma de Estudo: Clínico prospectivo randomizado. Material e Método: Cinquenta e cinco crianças de 2 a 12 anos, com histó-ria de obstrução das vias aéreas superiores por hiperplasia adenoamigdaliana foram submetidas a exame antropométrico (peso e altura), antes e 6 meses após a adenoamigdalectomia. Os dados foram transformados em percentil para peso e altura, de acordo com a idade e comparados através de análise estatísti-ca. Resultados: No pré-operatório, encontramos a seguinte distribuição para o percentil altura: 78,2%, abaixo de p75 e para peso 70,9% abaixo de p50. No pós-operatório observouse melhor distribuição das crianças: para altura 34,6% abaixo de p75, 32,8% entre p75-95 e 32,6% para p95 e acima e para peso: 35,5% abaixo de p50, 36,4% para p50-95 e 29,1% acima de p95. Conclusão: Observou-se uma melhora considerável do desenvolvimento pôndero-estatural das crianças após a adenoamigdalectomia. Tonsi l and adenoid hyperplasia is one of the most common causes of upper airway obstruction in children; and generally comes along with sleep apnea. It is usually associated to poor school performance, non-specific behavioral disturbs, hyperactivity, daytime sleepiness, distraction and failure to thrive. This one is a very serious consequence for the child. The purpose of this study is to compare height and weight percentiles before and after surgery. Study Design: Clinical prospective randomized. Material and Method: We studied 55 children (male and female) from 2 to 12 years old; with upper airway obstruction due to tonsil and adenoid hyperplasia. All of them were measured (height and weight) before and 6 months after adenotonsillectomy. Height and weight percentiles were plotted in graphics and compared with statistical analysis. Results. Before surgery, the majority of the children, 78.2% were under p75 for height and 70.9% were under p50 for weight. Three months after surgery there was a better distribution of the children throughout the percentil ranges. For height: 34.6% were under p75; 32.85 were between p75-95 and 32.6% were above p95. For weight 35.5% were under p50; 36.4% were under p50-95 and 29.1% were above p95. Conclusion: After surgery, children presented an improvement in their height and weight percentiles. They develop better after the treatment of upper airway obstruction, with T&A surgery. Rev Bras Otorrinolaringol. V.69, n.2, 193-6, mar./abr. 2003 Ren...

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“…Secretory growth hormone bursts are known to rise after sleep onset during slow wave sleep (sleep stages 3 and 4) 35,36 with linear relationships between the amount of slow wave sleep and concomitant GH secretion identifying an important correspondence between sleep state and growth hormone secretory patterns. 37 Decreased time in slow wave sleep has been found among children with psychosocial dwarfism 38 and young adults with isolated growth hormone deficiency. 39 In the present study, not only did length growth saltations follow increased napping and longer sleep, but the co-sleeping infant experienced less sleep fragmentation, 40 common in cosleeping infants and specifically associated with reduced stages 3-4 sleep.…”

Section: Discussionmentioning

confidence: 99%