Relationship between Somatic Mutations and Clinic Pathological of Follicular Variant Papillary Thyroid Carcinoma: A MetaAnalysis

Abstract

Background and aims: The incidence of somatic mutations and clinicopathological features in Follicular Variant Papillary Thyroid Carcinoma (FVPTC) demonstrate inconsistent findings. Materials and methods: A total of 104 publications from PubMed/MEDLINE, Embase and The Cancer Genome Atlas (TCGA) were included in this meta-analysis. One meta-analysis assessed the histology-specific prevalence, while another examined the clinical features of mutant carriers. Furthermore, the mutational landscape of FVPTC was analyzed using data from TCGA database.