Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood

Wajner, Moaçir; Papiha, S. S.; Wagstaff, Thomes Jan

doi:10.1515/jpme.1986.14.2.115

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…The existence and role of several factors in fluencing AFP concentration is not yet clear today. It is supposed that they regulate pro tein synthesis and catabolism and might elicit their effect through the fetomaternal barrier [ 13].…”

Section: Discussionmentioning

confidence: 99%

Maternal Age-Dependent and Sex-Related Changes of Gestational Serum Alpha-Fetoprotein

Szabó¹,

Veress²,

Münnich

et al. 1995

Fetal Diagn Ther

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Maternal serum alpha-fetoprotein (MSAFP) concentration values were measured in relation to maternal age and fetal sex in the 16th to 20th gestational weeks in samples taken from 9,556 pregnancies with the outcome of live, mature and healthy infants. Our results show positive significance between MSAFP concentration and maternal age (p < 0.001); we also found significantly higher AFP values in male fetuses than in female fetuses (p < 0.001). This specificity is y all probability due to the change in the physiologic AFP concentration of the pregnant woman. Considering maternal age and the new percentile AFP values, cutoff concentration values can be corrected, thus the quality of routine AFP screening can be improved. At the same time, with the application of the above parameters, a more effective selection of pregnancies at high risk for Down syndrome can be achieved.

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Section: Discussionmentioning

confidence: 99%

Maternal Age-Dependent and Sex-Related Changes of Gestational Serum Alpha-Fetoprotein

Szabó¹,

Veress²,

Münnich

et al. 1995

Fetal Diagn Ther

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Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: Evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts

et al. 1999

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Previous studies suggest that the relationship between genes and nonsyndromic cleft lip ± cleft palate (CLP) or cleft palate only (CP) may be modified by the environment. Using data from a population‐based case‐control study, we examined allelic variants for three genes, i.e., transforming growth factor alpha (TGFA), transforming growth factor beta 3 (TGFB3), and Msh (Drosophila) homeobox homolog 1 (MSX1), and their interactions with two exposures during pregnancy (maternal cigarette smoking and alcohol consumption) as risk factors for CLP and CP. For each cleft phenotype, risk estimates associated with most allelic variants tended to be near unity. Risk estimates for maternal smoking (≥10 cigarettes/day) were significantly elevated for CP and were most elevated among infants with allelic variants at the TGFB3 or MSX1 sites. By comparison, risk estimates for maternal alcohol consumption (≥4 drinks/month) were significantly elevated for CLP and were most elevated among infants with allelic variants at the MSX1 site. Our results suggest that development of CLP and CP may be influenced independently by maternal exposures but more significantly by interaction of such exposures and specific allelic variants. Teratology 59:39–50, 1999. © 1999 Wiley‐Liss, Inc.

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Biochemical Assessment and Prediction of Gestational Well-Being

Martin

Cowan

1990

Obstetrics and Gynecology Clinics of North America

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Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood

Cited by 3 publications

References 11 publications

Maternal Age-Dependent and Sex-Related Changes of Gestational Serum Alpha-Fetoprotein

Maternal Age-Dependent and Sex-Related Changes of Gestational Serum Alpha-Fetoprotein

Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: Evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts

Biochemical Assessment and Prediction of Gestational Well-Being

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