Relationship between sputum clusterin levels and childhood asthma

Sol, In Suk; Kim, Yoon Hee; Park, Young A; Lee, Jun Young; Hong, Jung Yeon; Kim, Seung Up; Kim, Yun Seon; Oh, Mi Seon; Yoon, Seo Hee; Kim, Min Jung; Kim, Kyung Won; Sohn, Myung Hyun; Kim, Kyu‐Earn

doi:10.1111/cea.12686

Cited by 21 publications

(15 citation statements)

References 45 publications

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“…[17] Spirometry (VIASYS Healthcare, Inc., Conshohocken, PA) was performed, and flow volume was obtained according to the American Thoracic Society guidelines before and after BD inhalation, [18] In a challenge test, each child inhaled increasing concentrations of methacholine (0.075, 0.15, 0.31, 0.62, 1.25, 2.5, 5, 10, 25, and 50 mg/mL) nebulized by a dosimeter (MB3; Mefar, Brescia, Italy) until FEV 1 reduced by 20% from a post-nebulized saline solution value. The bronchial response was expressed as the provocative concentration of methacholine causing a 20% decrease in the FEV 1 (PC 20 ; measured in milligrams per milliliter) and was calculated by linear interpolation of the log dose–response curve.…”

Section: Methodsmentioning

confidence: 99%

“…For sputum induction and processing, we used the protocol described by Yoshikawa et al [20] As we described previously, [17] all children were instructed to wash their mouths thoroughly with water. Then, they inhaled a 3% saline solution nebulized in an ultrasonic nebulizer (NE-U12; Omron Co., Tokyo, Japan) at maximum output at room temperature.…”

Section: Methodsmentioning

confidence: 99%

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Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma

Kim

Lee²,

Sol³

et al. 2016

Medicine

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Pentraxin 3 (PTX3) is a soluble pattern recognition receptor and an acute-phase protein. It has gained attention as a new biomarker reflecting tissue inflammation and damage in a variety of diseases. Aim of this study is to investigate the role of PTX3 in childhood asthma.In total, 260 children (140 patients with asthma and 120 controls) were enrolled. PTX3 levels were measured in sputum supernatants using enzyme-linked immunosorbent assay test. We performed spirometry and methacholine challenge tests and measured the total eosinophil count and the serum levels of total IgE and eosinophil cationic protein (ECP) in all subjects.Sputum PTX3 concentration was significantly higher in children with asthma than in control subjects (P < 0.001). Furthermore, sputum PTX3 levels correlated with atopic status and disease severity among patients with asthma. A positive significant correlation was found between sputum PTX3 and the bronchodilator response (r = 0.25, P = 0.013). Sputum PTX3 levels were negatively correlated with forced expiratory volume in 1 second (FEV1) (r = -0.30, P = 0.001), FEV1/forced vital capacity (FVC) (r = -0.27, P = 0.002), and FEF25–75 (r = -0.392, P < 0.001), which are indicators of airway obstruction and inflammation. In addition, the PTX3 concentration in sputum showed negative correlations with post-bronchodilator (BD) FEV1 (r = -0.25, P < 0.001) and post-BD FEV1/FVC (r = -0.25, P < 0.001), which are parameters of persistent airflow limitation reflecting airway remodeling.Sputum PTX3 levels increased in children with asthma, suggesting that PTX3 in sputum could be a candidate molecule to evaluate airway inflammation and remodeling in childhood asthma.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma

Kim

Lee²,

Sol³

et al. 2016

Medicine

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“…Clusterin is a ubiquitous antioxidant glycoprotein. In a study by Soi et al, salivary levels of clusterin were elevated in asthmatic children compared to controls and levels were positively correlated with clinical severity particularly children with eosinophilic asthma. Interestingly, salivary levels were reduced in children with asthma exacerbations possible related to clusterin “consumption” by oxidants or the use of systemic corticosteroids.…”

Section: Asthma and Rhinitismentioning

confidence: 93%

“…Clusterin is a ubiquitous antioxidant glycoprotein. In a study by Soi et al, 106 Periostin is now one of the more studied asthma biomarkers. In this population, Caswell-Smith et al explore normal ranges (wide) in an adult population without asthma or COPD.…”

Section: Biomarkersmentioning

confidence: 99%

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

Roberts

Boyle

Crane

et al. 2017

Clin Experimental Allergy

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“…Asthma is a chronic airway inflammatory disease . Assessing airway inflammation is important for studying the underlying mechanisms of asthma.…”

Section: Introductionmentioning

confidence: 99%

Exhaled breath temperature as a tool for monitoring asthma control after an attack in children

Sol

Kim

et al. 2019

Pediatric Pulmonology

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Background Exhaled breath temperature (EBT) has been suggested as a non‐invasive marker of airway inflammation in asthma. There have been no studies examining longitudinal changes in EBT following asthma attacks. Objective To investigate changes in EBT during and after an asthma attack and to relate these changes to changes in respiratory physiological measurements. Methods We evaluated 38 hospitalized children aged 5‐18 years diagnosed with an asthma attack. Spirometry was performed upon hospitalization. During hospitalization, EBT, peak expiratory flow rate (PEFR), and asthma score were measured daily. These tests were repeated 1 week and 1 month after discharge. The overall PEFR change, temporal changes in plateau values at the end of expiration, and time‐dynamic associations were evaluated using linear mixed models. Results FEV1 was lower at admission than at discharge (63.3 ± 24 vs 99.5 ± 14 percent of predicted, P < 0.001). The EBT was higher at admission than at 1 week after discharge (34.1°C [range: 33.9‐34.8°C] vs 33.6°C [range: 33.0‐34.2°C], P = 0.007); overall, EBTs decreased over time (P = 0.007). Among individual subjects, decreased EBT was correlated with increased PEFR over time. Furthermore, plateau values at the end of expiration had a time‐dependent, dynamic association with the PEFR during hospitalization (P = 0.005) and between asthma attack onset and asthma status stabilization (P = 0.032). Conclusions The EBT was elevated during asthma attacks and gradually decreased until asthma was well controlled. The EBT may be a useful, non‐invasive tool for monitoring asthma control in children.

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Relationship between sputum clusterin levels and childhood asthma

Cited by 21 publications

References 45 publications

Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma

Sputum pentraxin 3 as a candidate to assess airway inflammation and remodeling in childhood asthma

Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy

Exhaled breath temperature as a tool for monitoring asthma control after an attack in children

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