Relationship between squamous cell carcinoma of the tongue and the position of dental prosthesis

Abstract

PURPOSESquamous cell carcinoma (SCC) of the tongue has a relatively high incidence of all oral cancers. Some studies have reported a relationship between intraoral dental prosthesis and SCC of the tongue; however, this relationship remains controversial. The purpose of this study was to investigate the relationship between SCC of the tongue and the positional aspects of dental prosthesis using a retrospective analysis.MATERIALS AND METHODSA total of 439 patients with SCC of the tongue were diagnosed and treated in the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. Patients were treated over a 12.5-year period ranging from January 1, 2001 to June 30, 2013. Statistical analysis was performed to examine potential differences between the groups.RESULTSThe number of patients with a crown and/or a bridge (134, 63.5%) was significantly different than the number of patients without a prosthesis (77, 36.5%). Even after accounting for different types of prostheses such as crowns, bridges, and dentures, no significant differences were observed between the position of the prosthesis and the location of the SCC of the tongue, with significance defined as a P-value less than .05 by the Pearson-Chi square test.CONCLUSIONPatients with crowns and/or bridges exhibited more frequent SCC of the tongue compared with patients without these prosthesis. These data support the hypothesis that mechanical trauma and galvanic phenomena play a role in the etiology of SCC of the tongue.

Lack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis

“…Because OSCC occur predominantly at sites of denture trauma, the scientific community has been asking whether chronic dental trauma and irritation are carcinogenic . We investigated the association of dental trauma with LOH, an early genetic change in oral tumorigenesis.…”

“…Tobacco and alcohol use are the classical etiologic factors for oral squamous cell carcinoma (OSCC). Chronic trauma is suggested to be an additional etiologic risk factor for OSCC, and patients with crowns and/or bridges exhibited higher frequency of OSCC in the tongue compared to patients without these prostheses . Moreover, OSCC occurs predominantly at sites of potential dental and denture trauma, especially in non‐smoker patients .…”

Evaluation of Aetiological Role of Misdirected Tooth in the Incidence of Squamous Cell Carcinoma of Oral Cavity

“…Studies in animal models have shown that there is an effect of ethanol on the penetration of nitrosonornicotine (From tobacco) into the oral mucosa. [33] CONCLUSION This clinical retrospective study included 48 patients having chronic non-healing ulcer(s) in the oral cavity between the interval of July 2014 and March 2016. On histopathological examination, 42 patients were found to be OSCC patients.…”

Cellular Alteration of the Oral Mucosa due to Orthodontic Appliances and Tobacco Smoking: A Cytomorphometric Study

“…8,10 Few articles have also indicated the effects of sharp tooth, edentulousness and para-functional habits in causing deleterious effects on the oral mucosa. 8,9,11 The irritation of oral mucosa during orthodontic treatment needs attention in this regard. Worldwide, tobacco use is a leading cause of deaths amounting to above five million per year, and based on the current scenario it can be assumed that tobacco usage would cause around ten million cases of mortality annually by the year 2030.…”