Relationship Between the Gastrointestinal Side Effects of an Anti-Hypertensive Medication and Changes in the Serum Lipid Metabolome

Ahn, Yoomin; Nam, Myung Hee; Kim, Eungbin

doi:10.3390/nu12010205

Cited by 4 publications

(5 citation statements)

References 52 publications

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“…occurred due to the induced microbiota compositional change in amlodipine versus amlodipine and probiotic treated mice. 80 Lipid metabolites in amlodipine treated mice had increased levels of phosphatidylcholines, triglycerides with large numbers of double bonds, and cholesterols. The amlodipine treated group also had decreased levels of triglycerides with small numbers of double bonds.…”

Section: Ahn Et Al Followed Up By Investigating What Metabolite Alter...mentioning

confidence: 99%

“…The authors believed this to be evident that amlodipine shifted the composition and balance of bacterial produced metabolites that ultimately contribute to the GI side effects. 80 Similarly, the calcium channel blockers nifedipine and nimodipine have been investigated for microbial attenuation. Nifedipine and nimodipine have similar mechanisms of action in the treatment of hypertension, and thus, evidence for one drug's relationship with the gut microbiome is potential evidence for the other.…”

Section: Ahn Et Al Followed Up By Investigating What Metabolite Alter...mentioning

confidence: 99%

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Role of the gut microbiome in cardiovascular drug response: The potential for clinical application

et al. 2021

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Response to cardiovascular drugs can vary greatly between individuals, and the role of the microbiome in this variability is being increasingly appreciated. Recent evidence indicates that bacteria and other microbes are responsible for direct and indirect effects on drug efficacy and toxicity. Pharmacomicrobiomics aims to uncover variability in drug response due to microbes in the human body, which may alter drug disposition through microbial metabolism, interference by microbial metabolites, or modification of host enzymes. In this review, we present recent advances in our understanding of the interplay between microbes, host metabolism, and cardiovascular drugs. We report numerous cardiovascular drugs with evidence of, or potential for, gut-microbe interactions. However, the effects of gut microbiota on many cardiovascular drugs are yet uninvestigated. Finally, we consider potential clinical applications for the described findings.

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Section: Ahn Et Al Followed Up By Investigating What Metabolite Alter...mentioning

confidence: 99%

Section: Ahn Et Al Followed Up By Investigating What Metabolite Alter...mentioning

confidence: 99%

Role of the gut microbiome in cardiovascular drug response: The potential for clinical application

et al. 2021

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“…Recent studies have discovered that metabolites in peripheral blood are associated with the development of liver disease [6], arthritis [7], chronic kidney disease [8], and Alzheimer's disease [9]. In patients with HTN, altered serum metabolic signatures may involve metabolism of fatty acid, glycerophospholipid, alanine, aspartate, and glutamate [10,11]. In addition, significantly different metabolites in HTN have been identified in a pilot study and a randomized clinical trial [12,13].…”

Section: Introductionmentioning

confidence: 99%

Integrated Omic Analysis of Human Plasma Metabolites and Microbiota in a Hypertension Cohort

Chen

Lin

et al. 2023

Nutrients

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Hypertension is closely related to metabolic dysregulation, which is associated with microbial dysbiosis and altered host–microbiota interactions. However, plasma metabolite profiles and their relationships to oral/gut microbiota in hypertension have not been evaluated in depth. Plasma, saliva, subgingival plaques, and feces were collected from 52 hypertensive participants and 24 healthy controls in a cross-sectional cohort. Untargeted metabolomic profiling of plasma was performed using high-performance liquid chromatography–mass spectrometry. Microbial profiling of oral and gut samples was determined via 16S rRNA and metagenomic sequencing. Correlations between metabolites and clinic parameters/microbiota were identified using Spearman’s correlation analysis. Metabolomic evaluation showed distinct clusters of metabolites in plasma between hypertensive participants and control participants. Hypertensive participants had six significantly increased and thirty-seven significantly decreased plasma metabolites compared to controls. The plasma metabolic similarity significantly correlated with the community similarity of microbiota. Both oral and gut microbial community composition had significant correlations with metabolites such as Sphingosine 1-phosphate, a molecule involved in the regulation of blood pressure. Plasma metabolites had a larger number of significant correlations with bacterial genera than fungal genera. The shared oral/gut bacterial genera had more correlations with metabolites than unique genera but shared fungal genera and metabolites did not show clear clusters. The hypertension group had fewer correlations between plasma metabolites and bacteria/fungi than controls at species level. The integrative analysis of plasma metabolome and oral/gut microbiome identified unreported alterations of plasma metabolites in hypertension and revealed correlations between altered metabolites and oral/gut microbiota. These observations suggested metabolites and microbiota may become valuable targets for therapeutic and preventive interventions of hypertension.

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“…Soy protein intake whether in the morning or evening led to a greater microbiota diversity and a decrease in cecal pH resulting from SCFA production compared with casein intake [16]. Finally, Ahn et al [17] investigated the metabolomics changes in rats that received amlodipine. Serum levels of phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, triglycerides with large numbers of double bonds, cholesterol, sterol derivatives, and cholesterol esters were increased.…”

mentioning

confidence: 99%

“…Serum levels of phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, triglycerides with large numbers of double bonds, cholesterol, sterol derivatives, and cholesterol esters were increased. Amlodipine-induced compositional changes in the gut microbiota are a causal factor in inflammation [17].…”

mentioning

confidence: 99%

Nutrition, Microbiota and Noncommunicable Diseases

Plaza‐Díaz

2020

Nutrients

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Relationship Between the Gastrointestinal Side Effects of an Anti-Hypertensive Medication and Changes in the Serum Lipid Metabolome

Cited by 4 publications

References 52 publications

Role of the gut microbiome in cardiovascular drug response: The potential for clinical application

Role of the gut microbiome in cardiovascular drug response: The potential for clinical application

Integrated Omic Analysis of Human Plasma Metabolites and Microbiota in a Hypertension Cohort

Nutrition, Microbiota and Noncommunicable Diseases

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