2019
DOI: 10.3390/ijerph16091551
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Relationship between the IL23R SNPs and Crohn’s Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study

Abstract: It is suggested that IL-23/IL-17 axis and single nucleotide polymorphisms (SNPs) of IL23R may have crucial role in pathogenesis of Crohn’s disease (CD). Thus, we sought to assess the IL23R SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common IL23R SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1… Show more

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Cited by 7 publications
(5 citation statements)
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“…IL-23 is a pro-in ammatory cytokine which embarks a cascade of in ammatory factors via activation of IL-17, a well-known mediator of in ammation (8). Consequently, the association of IL-23R gene variations with disorders of the immune system has been studied in several studies (22)(23). So far, none of the SNPs in the IL-23R gene was reported to be associated with the susceptibility to SLE in the Hungarian, Korean and Chinese patients (24)(25)(26).…”
Section: Discussionmentioning
confidence: 99%
“…IL-23 is a pro-in ammatory cytokine which embarks a cascade of in ammatory factors via activation of IL-17, a well-known mediator of in ammation (8). Consequently, the association of IL-23R gene variations with disorders of the immune system has been studied in several studies (22)(23). So far, none of the SNPs in the IL-23R gene was reported to be associated with the susceptibility to SLE in the Hungarian, Korean and Chinese patients (24)(25)(26).…”
Section: Discussionmentioning
confidence: 99%
“…Данный факт находит подтверждение при исследовании концентрации иммуноглобулинов в сыворотке. ИЛ-23 рассматривается как связующее звено между реакциями врожденного и адаптивного иммунитета в патогенезе БК и потенциальная терапевтическая мишень, полиморфизмы генов оси ИЛ-23/Th 17 характерны для больных с БК [22][23][24]. ИЛ-23 при БК имеет значение в дифференцировке Th0 в Th17, участвует в активации лимфоидных клеток врожденного иммунитета [25][26][27].…”
Section: Discussionunclassified
“…However, these associations did not remain significant after the statistical correction was applied [ 31 ]. Specific polymorphisms of the same allele rs1004819, as well as the allele rs7517847, also seem to be associated with stricturing/penetrating behavior in a Polish and Bosnian cohort analyzed in a study by Borecki et al [ 32 ].…”
Section: Pathogenetic Mechanisms Of Intestinal Fibrosis In CDmentioning
confidence: 99%