Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Tamba, Sachiko; Nizhizawa, Hitoshi; Funahashi, Tohru; Okauchi, Yukiyoshi; Ogawa, Takumi; Noguchi, Midori; Fujita, Köichi; Ryo, Miwa; Kihara, Shinji; Iwahashi, Hiromi; Yamagata, Kazuya; Nakamura, Tadashi; Shimomura, Iichiro; Matsuzawa, Yūji

doi:10.2169/internalmedicine.48.e003

Cited by 23 publications

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“…The current study's findings show a positive association between elevated serum uric acid and excess body weight and central obesity. Such findings are consistent with those of other studies 37,38,39 .…”

Section: Discussionsupporting

confidence: 94%

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Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

et al. 2011

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IntroductionThe scientific literature makes widespread reference to the association between chronic noncommunicable diseases, especially rheumatic and cardiovascular diseases, and hyperuricemia 1,2,3 . The relationship between excess plasma uric acid and gout is described in the literature, but despite all the studies and technological advances, there is still limited evidence to show a direct relationship between hyperuricemia and cardiovascular diseases 3,4,5 .According to previous studies, some foods can help increase or decrease the serum uric acid levels 6,7,8 , depending on their purine content. There is still little information on the exact amount of purines contained in foods, since their content and availability depend on the food processing procedures, among other factors 4,9,10 .Various studies 3,8,11,12,13 have pointed to excessive intake of fat, alcohol, and fructose, as well as changes in body weight (both excess weight and sudden weight loss) as risk factors for hyperuricemia. In addition, a reduction in the consumption of protein-rich foods (especially animal protein) can help decrease the blood uric acid levels 11,13 . The literature includes reports that excess body fat may be the most important nutritional factor for hyperuricemia 2,4,14 .According to previous publications, hyperuricemia is associated with various chronic diseases such as arterial hypertension, cardio-ARTIGO ARTICLE Poletto J et al. 370 Cad. Saúde Pública, Rio de Janeiro, 27(2):369-378, fev, 2011

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Section: Discussionsupporting

confidence: 94%

“…This relationship is still not totally clear in the literature, but there is purportedly a reduced renal excretion of uric acid in individuals with hyperuricemia and dyslipidemia 41 . Other studies have also shown a positive association between hypertriglyceridemia and hyperuricemia 37,38,39,41 .…”

Section: Discussionmentioning

confidence: 83%

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

et al. 2011

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“…Visceral fat has high metabolic activity and releases free fatty acids and adipokines such as leptin, tumor necrosis factor-a, and adiponectin. [31][32][33][34] Insulin resistance caused by increasing tumor necrosis factor-a secretion or decreasing adiponectin secretion induces hypertension and glucose intolerance. 31 Leptin and angiotensinogen secreted from visceral fat also induces hypertension.…”

Section: Discussionmentioning

confidence: 99%

Fatty liver incidence and predictive variables

et al. 2010

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Although fatty liver predicts ischemic heart disease, the incidence and predictors of fatty liver need examination. The objective of this study was to determine fatty liver incidence and predictive variables. Using abdominal ultrasonography, we followed biennially through 2007 (mean follow-up, 11.6±4.6 years) 1635 Nagasaki atomic bomb survivors (606 men) without fatty liver at baseline (November 1990 through October 1992. We examined potential predictive variables with the Cox proportional hazard model and longitudinal trends with the Wilcoxon rank-sum test. In all, 323 (124 men) new fatty liver cases were diagnosed. The incidence was 19.9/1000 person-years (22.3 for men, 18.6 for women) and peaked in the sixth decade of life. After controlling for age, sex, and smoking and drinking habits, obesity (relative risk (RR), 2.93; 95% confidence interval (CI), 2.33-3.69, Po0.001), low high-density lipoprotein-cholesterol (RR, 1.87; 95% CI, 1.42-2.47; Po0.001), hypertriglyceridemia (RR, 2.49; 95% CI, 1.96-3.15; Po0.001), glucose intolerance (RR, 1.51; 95% CI, 1.09-2.10; P¼0.013) and hypertension (RR, 1.63; 95% CI, 1.30-2.04; Po0.001) were predictive of fatty liver. In multivariate analysis including all variables, obesity (RR, 2.55; 95% CI, 1.93-3.38; Po0.001), hypertriglyceridemia (RR, 1.92; 95% CI, 1.41-2.62; Po0.001) and hypertension (RR, 1.31; 95% CI, 1.01-1.71; P¼0.046) remained predictive. In fatty liver cases, body mass index and serum triglycerides, but not systolic or diastolic blood pressure, increased significantly and steadily up to the time of the diagnosis. Obesity, hypertriglyceridemia and, to a lesser extent, hypertension might serve as predictive variables for fatty liver.

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“…Studije pokazuju da je redukcija visceralnog masnog tkiva povezana sa značajnim sniženjem nivoa MK, i da su i adiponektin i visceralno masno tkivo značajno korelirali sa MK [13]. Ovakav nalaz ukazuje na potencijalnu ulogu visceralnog masnog tkiva per se u regulaciji metabolizma purina i MK.…”

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Influence of obesity on serum uric acid level in postmenopausal women

Klisić¹,

Kotur‐Stevuljević²,

Kavarić³

et al. 2016

Tim Med Glas

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(1) DOM ZDRAVLJA, PODGORICA, CRNA GORA, (2) FARMACEUTSKI FAKULTET, UNIVERZITET U BEOGRADU, SRBIJA Sažetak :Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol -vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p<0,001), zatim cistatin C (Beta=0,300; p<0,001), (R2=0,467; p<0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti. Ključne riječi: inflamacija, gojaznost, menopauza, mokraćna kiselina. Summary:Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p<0.001), and cystatin C (Beta=0.300, p<0.001)...

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Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men

Cited by 23 publications

References 0 publications

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

Fatty liver incidence and predictive variables

Influence of obesity on serum uric acid level in postmenopausal women

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