Relationship between triglyceride glucose index, retinopathy and nephropathy in Type 2 diabetes

Srinivasan, Sangeetha; Singh, Pallavi; Kulothungan, Vaitheeswaran; Sharma, Tarun; Raman, Rajiv

doi:10.1002/edm2.151

Cited by 34 publications

(37 citation statements)

References 39 publications

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“…Several studies suggested that TyG index plays a role in nephric microvascular damage. Srinivasan S et al ( 43 ) showed a higher TyG index was associated with the presence of retinopathy and nephropathy in individuals with diabetes and could be used for monitoring metabolic status in clinical settings. Liu et al ( 44 ) showed the TyG index was independently associated with DN in patients with type 2 diabetes, and was a better marker than HOMA2-IR for the identification of DN in type 2 diabetes patients in a cross-sectional study.…”

Section: Discussionmentioning

confidence: 99%

Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

Gao

Sun

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveWe aimed to explore the association between the triglyceride-glucose (TyG) index, a marker of insulin resistance (IR), and vascular target organ damage (TOD) in a Beijing community-based population, China.MethodsA total of 6,015 participants from an atherosclerosis cohort survey performed in the Shijingshan District in Beijing, China were included in our analysis. Vascular TOD, such as carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), and the urine albumin-to-creatinine ratio (UACR) were all evaluated.ResultsThe overall mean age of all the participants was 62.35 years, 3,951 (65.69%) were female, and mean TyG index was 8.81. In univariable regression analyzes, an increased TyG index was associated with higher cfPWV, baPWV, lnUACR, and higher risk of cfPWV ≥ 10 m/s, baPWV ≥ 1,800 cm/s, and UACR ≥ 30 mg/g, respectively. Multivariable regression analyzes showed subjects with the TyG index in top tertile had a significant increase in cfPWV (β = 0.29 m/s; 95% confidence interval [95% CI] 0.19–0.40; pfortrend < 0.001), baPWV (β = 69.28 cm/s; 95% CI 50.97–87.59; pfortrend < 0.001), lnUACR (β = 0.23; 95% CI 0.13–0.34; pfortrend < 0.001), and had a higher risk of cfPWV ≥ 10 m/s (odds ratio [OR] = 1.47; 95% CI 1.17–1.85; pfortrend < 0.001), baPWV ≥ 1,800 cm/s (OR = 1.79; 95% CI 1.48–2.17; pfortrend < 0.001), and UACR ≥ 30 mg/g (OR = 1.71; 95% CI 1.30–2.24; pfortrend < 0.001) after fully adjusting for age, sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), self-reported coronary heart disease (CHD) and stroke, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. Consistent conclusions were obtained in the subgroups without hypoglycemic and lipid-lowering medications or aged younger than 65 years old.ConclusionsThe TyG index was positively associated with artery stiffness and nephric microvascular damage in a Beijing community-based population in China. This result provides evidence that the TyG index may serve as a simple and effective indicator to reflect vascular TOD.

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Section: Discussionmentioning

confidence: 99%

Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

Gao

Sun

et al. 2022

Front. Cardiovasc. Med.

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“… 21 A high TyG index is associated with the presence of retinopathy and nephropathy in individuals with diabetes and can be used for monitoring metabolic status in clinical settings. 22 , 23 In addition, a high TyG index is associated with an increased risk of microalbuminuria, and TyG can effectively identify individuals at risk of non-alcoholic fatty liver disease (NAFLD) since it is highly sensitive to the detection of NAFLD subjects, and can be suitable as a diagnostic standard for Chinese adults with NAFLD. 24 , 25 Previous studies have confirmed that vitamin D is independently related to IR in patients with T2DM, but the study applied HOME-IR to reflect insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Triglyceride Glucose Index and Vitamin D in Type 2 Diabetes Mellitus

Jia

Song²,

et al. 2022

DMSO

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Purpose The study aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH) D] and triglyceride glucose index (TyG) levels in male and female patients with type 2 diabetes mellitus (T2DM). Patients and Methods This cross-sectional study recruited 592 patients with type 2 diabetes. The subjects were divided into the non-vitamin D deficiency group [25(OH)D≥20ng/mL] and the vitamin D deficiency group [25(OH)D<20ng/mL]. The triglyceride glucose (TyG) index is calculated using the following formula, ln[fasting triglycerides (mg/dL)*fasting blood glucose (mg/dL)/2]. Participants were divided into high TyG group and low TyG group, with the median of TyG as the boundary. All participants were divided into male and female groups and normal Body mass index (BMI) and high BMI groups, and then divided into high TyG group and low TyG group. Results We found that TyG levels are independently and negatively correlated with vitamin D levels in male patients with T2DM. In the female group, there was no significant correlation between TyG and vitamin D levels, regardless of an adjusted or unadjusted confounding factor. Subgroup analysis showed that the correlation between TyG and the risk of vitamin D deficiency in the normal BMI group was significantly stronger than that in the high BMI group. Conclusion This study indicates that vitamin D deficiency is related to high TyG level in patients with T2DM for males, and this relationship is not significant for female patients. The risk of vitamin D deficiency is significantly correlated with high TyG level in normal BMI group. However, there was no statistically significant difference between TyG level and the risk of vitamin D deficiency in the high BMI group. Difference between TyG level and the risk of vitamin D deficiency.

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“…The TyG index, derived from FBG and TG, was proven to be a reliable and simple surrogate for metabolic syndrome and IR [18]. Mounting evidence has proved the crucial value of TyG index in predicting diabetic complications in patients with T2DM [19][20][21]. Study by Liu et al showed a signi cant association between TyG index and the risk of diabetic nephropathy in 682 adult patients with T2DM [22].…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes

Wang

Zhang

et al. 2022

Preprint

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Objectives The triglyceride-glucose (TyG) index has been identified as a reliable and simple surrogate of insulin resistance. In this study, we sought to determine the association between TyG index and cardiac function among asymptomatic individuals with type 2 diabetes (T2DM) without history of any cardiovascular disease. Materials and Methods The cross-sectional study enrolled 180 T2DM patients without cardiac symptoms. Heart failure with preserved ejection fraction (HFpEF) was defined as Heart Failure Association (HFA)-PEFF score ≥ 5 points. Results A total of 38 (21.1%) diabetic patients were identified with HFpEF. Compared with the low-TyG group (TyG index < 9.47), patients in high-TyG group (TyG index ≥ 9.47) showed increased risk of metabolic syndrome and diastolic dysfunction (P < 0.05 for each). Furthermore, after adjustment of confounding variables, the TyG index showed positive correlation with risk factors of metabolic syndrome (including BMI, HbA1c, TG, TC, non-HDL-C, and fasting blood glucose, P < 0.05 for each) and parameters of diastolic odysfunction (E/e’ ratio, P < 0.0001) in patients with T2DM. Moreover, receive operating characteristic analysis showed that the TyG index could be better to predict the risk of suspected HFpEF than other indicators (AUC: 0.706, 95% CI: 0.612–0.801). According, on multiple regression analysis, TyG index was independently correlated with the incidence of HFpEF (odds ratio: 0.883, P = 0.0003), indicating that TyG index could be a reliable biomarker to predict the risk of HFpEF. Conclusions The TyG index showed a positive correlation with the risk of subclinical HFpEF in patients with T2DM, providing a new marker to predict and treat HFpEF in diabetes.

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Relationship between triglyceride glucose index, retinopathy and nephropathy in Type 2 diabetes

Cited by 34 publications

References 39 publications

Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population

The Relationship Between Triglyceride Glucose Index and Vitamin D in Type 2 Diabetes Mellitus

Triglyceride-glucose index for the detection of subclinical heart failure with preserved ejection fraction in patients with type 2 diabetes

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