Relationship between Type A and B personality and debrisoquine hydroxylation capacity

Abstract

AimA person with Type A personality is an 'aggressor' compared with the rarely harried Type B. Although debrisoquine hydroxylase (CYP2D6) capacity has been associated with personality, no study has specifically investigated its association with personality Type A and B. Therefore the aim of this research was to study the impact of CYP2D6 on Type A and B personality. MethodsType A and B personality questionnaires were administered to 48 healthy patients undergoing elective orthopaedic surgery. After obtaining informed consent, patients were genotyped for the various CYP2D6 alleles by allele-specific polymerase chain reaction. Based on the genotypes, patients were grouped as extensive metabolizer (EM)1 (normal) ( CYP2D6 * 1/ * 1 ), EM2 (intermediate) ( CYP2D6 * 1/ * 4 , C YP2D6 * 1/ * 5 , CYP2D6 * 1/ * 9 and CYP2D6 * 1/ * 10 ) and EM3 (slow) ( CYP2D6 * 4/ * 10, CYP2D6 * 5/ * 10 , CYP2D6 * 10/ * 10 and CYP2D6 * 10/ * 17 ). c 2 was used to determine the relationship between the groups and personality types. ResultsThe percentages of patients who were of the EM1, EM2 and EM3 g roups were 20.8%, 52.1% and 27.1%, respectively. There was a significant difference ( P = 0.032) between the three groups in terms of personality type, in which EM1 showed a tendency to be of personality Type A while EM2 and EM3 tended to be of personality Type B. ConclusionThe study suggests that there is a relationship between CYP2D6 activity and Type A and B personality.

Could Endogenous Substrates of Drug-Metabolizing Enzymes Influence Constitutive Physiology and Drug Target Responsiveness?

“…Such differences in behavioral traits between CYP2D6 EMs and PMs are subtle in nature, and they do not necessarily indicate a clinical pathology or marked deviation from the normal range of human behavior. More recent investigations in other populations of healthy volunteers or patients had mixed results with some [27,28], but not all [29,30], studies suggesting a personality difference between EMs and PMs. Clearly, human personality is a complex phenotype that is Endogenous substrates of drug-metabolizing enzymes & drug target responsiveness -REVIEW subject to genetic, environmental and socio-cultural influences; it is not an easy task to discern the attendant role of a single genetic factor such as CYP2D6.…”

CYP2D6 genotype in relation to perphenazine concentration and pituitary pharmacodynamic tissue sensitivity in Asians: CYP2D6–serotonin–dopamine crosstalk revisited

“…anxiety proneness, impulsivity or ease in decision-making) [30,31,46,47]. More recent investigations in other populations had mixed results with some [48,49], but not all [50,51], studies suggesting a personality difference between CYP2D6 EMs and PMs. Some of the inconsistencies in the latter association studies may be attributable to use of CYP2D6 genotype to determine the EM status instead of CYP2D6 phenotype because there is an overlap in CYP2D6 activity between individuals who carry one or two active CYP2D6 genes.…”

CYP2D6 in the brain: genotype effects on resting brain perfusion

“…[12][13][14] Specifically, the poor metabolizer phenotype is thought to be associated with an anxious personality trait. 15,16 However, no consistent phenotype has been detected in other studies.…”