Relationship between Urological Disease and Inferior Vena Cava Reflux on Color Doppler Ultrasonography

Sugaya, Kimio; Matsumura, Eiri; Tasaki, Shinsuke; Kimura, Reiji; Kiyuna, Asuka; Nishijima, Saori; Kadekawa, Katsumi

doi:10.1111/j.1757-5672.2011.00086.x

Cited by 10 publications

(28 citation statements)

References 16 publications

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“…The prevalence of tricuspid regurgitation is very high, and reaches 70% among adults in Japan, whereas it is 17–68% in patients with otherwise “normal” hearts from the USA . Our previous ultrasonographic study showed that the prevalence of inferior vena cava reflux associated with tricuspid regurgitation in the supine position was significantly higher in women (68%) than in men (49%) attending our urological outpatient clinic . Chronic prostatitis in men and stress incontinence in women are related to inferior vena cava reflux, and there is also a possible relationship of urethral syndrome and cystocele with inferior vena cava reflux in women .…”

Section: Discussionmentioning

confidence: 90%

“…The causes of pelvic venous congestion include compression of the left renal vein (nutcracker phenomenon) into which the left gonadal vein flows, stenosis or obstruction of the internal pudendal vein and tricuspid regurgitation . The prevalence of tricuspid regurgitation is very high, and reaches 70% among adults in Japan, whereas it is 17–68% in patients with otherwise “normal” hearts from the USA .…”

Section: Discussionmentioning

confidence: 99%

“…CP/CPPS accounts for 90–95% of all prostatitis, with category III of CP/CPPS (various storage/voiding symptoms lasting more than 3 months or pelvic discomfort and pain associated with sexual‐related symptoms are present, but overt infection is not proven) according to the prostatitis classification proposed by the National Institute of Health in 1999 largely covering this disease . It has been suggested that pelvic venous congestion is involved in the pathogenesis of prostatitis, and chronic inflammation is also suspected to have a role …”

Section: Introductionmentioning

confidence: 99%

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Pelvic venous congestion with castration causes chronic prostatitis in rats

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Int J of Urology

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Objective To determine whether castration combined with pelvic congestion could cause chronic prostatitis, and to examine the effect of eviprostat in this rat model. Methods Male rats were divided into three groups, which were the sham, castration combined with pelvic congestion and castration combined with pelvic congestion plus eviprostat groups. Rats in the castration combined with pelvic congestion and castration combined with pelvic congestion plus eviprostat groups were anesthetized with isoflurane, after which ligation of the bilateral common iliac veins and castration were carried out. The sham and castration combined with pelvic congestion groups were fed a standard diet, whereas the castration combined with pelvic congestion plus eviprostat group was fed the same diet containing 0.1% eviprostat. After 4 weeks, continuous cystometry was carried out under urethane anesthesia. Then the bladder and the prostate gland were subjected to histological examination. Results There was no significant difference of the interval between bladder contractions in the sham and castration combined with pelvic congestion plus eviprostat groups, but the interval in the castration combined with pelvic congestion group was significantly shorter than the other groups. There was no difference in the maximum bladder contraction pressure among the three groups. Pathological inflammatory changes of the bladder wall were slightly more severe in the castration combined with pelvic congestion and castration combined with pelvic congestion plus eviprostat groups than in the sham group, whereas bladder vascularity was increased in the castration combined with pelvic congestion plus eviprostat group. In addition, pathological inflammatory changes and glandular atrophy of the prostate were more severe in the castration combined with pelvic congestion and castration combined with pelvic congestion plus eviprostat groups than in the sham group. Conclusion This rat model of pelvic congestion with castration might assist in the development of new treatments for chronic prostatitis and frequency.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pelvic venous congestion with castration causes chronic prostatitis in rats

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Int J of Urology

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“…Furthermore, when plasma was added dropwise to the bladder in a rat model, the maximum bladder contraction pressure increased, while the interval between the bladder contractions shortened (13). In a tranilast-induced interstitial cystitis rat model, carbazochrome increased both the locomotor activity and the interval between the bladder contractions (16), with benign prostatic hyperplasia (10) or intact female rats (28), naftopidil decreased plasma catecholamine levels and increased serotonin levels. In the present study, naftopidil also showed same results even in rats with pelvic venous congestion.…”

Section: Continuous Cystometrymentioning

confidence: 99%

“…Our previous study demonstrated that chronic prostatitis and stress urinary incontinence were related to the existence of vena cava reflux caused by tricuspid regurgitation (28). When we examined a female case with pelvic congestion syndrome using external iliac venography, we found that pelvic venous congestion occurred with tricuspid regurgitation and without pelvic venous valves (25).…”

mentioning

confidence: 99%

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

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The α1D/A receptor antagonist, naftopidil, inhibits micturition reflex by acting on various different sites. We examined the effects of naftopidil on bladder activity and changes in the induced urinary frequency using female rats with pelvic venous congestion (PC). Twenty-four female rats were divided into sham, PC, and PC/naftopidil groups. After anesthetizing rats in the PC and PC/naftopidil groups, the bilateral common iliac veins and uterine veins were ligated. Rats in the sham and PC groups were fed a standard diet, while rats in the PC/naftopidil group were fed diets containing 0.04% naftopidil. After 4 weeks of treatment, locomotor activity, urinary nitric oxide metabolites (NOx), continuous cystometry, and plasma monoamine measurements were performed. PC rats exhibited a decrease of locomotor activity, a shorter interval between bladder contractions on continuous cystometry, and decreased urinary NOx and plasma serotonin levels than the sham rats. The PC/naftopidil rats exhibited an increase of locomotor activity, a longer interval between bladder contractions, and increased urinary NOx and plasma serotonin levels. Therefore, naftopidil might improve bladder dysfunction induced by pelvic venous congestion due to several actions in the central nervous system and bladder tissue, as well as acting as an α1 blocker to cause pelvic venous dilation.Unilateral or bilateral ovarian vein incompetence can cause pelvic congestion syndrome, which induces chronic pain, irritable bladder, dysfunction of the pelvic organs, or vulval varices and varicose veins in the lower limbs (1, 5, 7). Our previous study demonstrated that chronic prostatitis and stress urinary incontinence were related to the existence of vena cava reflux caused by tricuspid regurgitation (28). When we examined a female case with pelvic congestion syndrome using external iliac venography, we found that pelvic venous congestion occurred with tricuspid regurgitation and without pelvic venous valves (25). Our previous studies have also demonstrated that ligation of the bilateral common iliac veins in male rats or ligation of the bilateral common iliac veins and uterine veins in female rats induced changes in the urinary frequency and low locomotor activity (30). As compared to the intact rats, these surgically altered rats exhibited a bladder blood flow decrease that was about 80% of the flow in the intact bladder. Therefore, pelvic venous congestion may be one of the causes of pelvic ischemia, and might be related to several lower urinary tract symptoms/diseases. When examining hypertension, the relevance of lower urinary tract symptoms and their association with hypertension need to be taken into consideration. Spontaneously hypertensive rats have been shown to have a significantly lower bladder capacity and voiding volume (24), and these rats also exhibit

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Relationship of blood flow in the common iliac vein to lower urinary tract disease

Sugaya¹,

Kadekawa²,

Unten³

et al. 2019

J Med Ultrasonics

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Relationship between Urological Disease and Inferior Vena Cava Reflux on Color Doppler Ultrasonography

Abstract: IVC reflux may be positively or negatively related to the occurrence of some urological diseases. Pelvic congestion secondary to IVC reflux may be one of the factors contributing to chronic prostatitis and stress incontinence.

Cited by 10 publications

References 16 publications

Pelvic venous congestion with castration causes chronic prostatitis in rats

Pelvic venous congestion with castration causes chronic prostatitis in rats

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

Relationship of blood flow in the common iliac vein to lower urinary tract disease

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