Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Li, Chunfeng; Ma, Yan; Yin, Wei; Xue, Yingwei

doi:10.1007/s11670-009-0122-8

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It stimulates epithelial cell motility, and is thus required for re-epithelialization. It is also a major stimulator of fibroblast migration and wound contraction, and is hypothesized to affect cell proliferation, embryo development and tumorigenesis ( 31 – 33 ). The effect of Cav-1 downregulation on EGF expression in fibroblasts was investigated in the present study.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells

Shi

Xiong

Liang

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

Reduced expression levels of caveolin-1 (Cav-1) in tumor stromal fibroblasts influences the occurrence and progression of tumors, particularly in breast cancer, but the relevant molecular mechanism is unclear. The present study aimed to clarify the potential mechanism underlying the promotion of tumor growth by reduced Cav-1 expression levels, by investigating Cav-1-targeted molecules in fibroblasts and breast cancer cells. The expression of growth factors in the ESF fibroblast cell line transfected with Cav-1 small interfering RNA (siRNA) was examined. The expression of apoptotic regulators in the BT474 breast cancer cell line that was co-cultured with the fibroblasts, was also investigated. The transfection of Cav-1-targeting siRNA in ESF cells resulted in efficient and specific inhibition of Cav-1 expression. The downregulation of Cav-1 increased the expression and secretion of stromal cell-derived factor-1 (SDF-1), epidermal growth factor (EGF) and fibroblast-specific protein-1 (FSP-1) in ESF cells. This resulted in the accelerated proliferation of the breast cancer cells. Tumor protein 53-induced glycolysis and apoptosis regulator (TIGAR) was upregulated in the BT474 cells under the condition of co-culture with Cav-1 siRNA fibroblasts, while levels of reactive oxygen species (ROS) were decreased, resulting in apoptosis inhibition in the breast cancer cells. These results demonstrated that the downregulation of Cav-1 promoted the growth of breast cancer cells through increasing SDF-1, EGF and FSP-1 in tumor stromal fibroblasts, and TIGAR levels in breast cancer cells. To the best of our knowledge, the present study supports the hypothesis that Cav-1 possesses tumor-suppressor properties, with the mechanism of Cav-1-dependent signaling involving the regulation of SDF-1, EGF, FSP-1 and TIGAR.

show abstract

Section: Discussionmentioning

confidence: 99%

Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells

Shi

Xiong

Liang

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Mirza‐Aghazadeh‐Attari

Reíter

Rikhtegar

et al. 2020

IUBMB Life

View full text Add to dashboard Cite

, a pleotropic molecule with a wide distribution, has received considerable attention in recent years, mostly because of its various major effects on tissues or cells since it has both receptor-dependent and receptor-independent actions over a wide range of concentrations. These biological and physiological functions of melatonin include regulation of circadian rhythms by modulating the expression of core oscillator genes, scavenging the reactive oxy-

show abstract

Relationship between VEGF, EGF and invasion, metastasis of gastric cancer cells

Cited by 2 publications

References 13 publications

Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells

Downregulation of caveolin-1 upregulates the expression of growth factors and regulators in co-culture of fibroblasts with cancer cells

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Contact Info

Product

Resources

About