Relationship Between Vitamin D Deficiency and the Components of Metabolic Syndrome in Patients with Morbid Obesity, Before and 1 Year After Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy

Entrenas, Ana Obispo; Tubio, David Legupin; Navarro, Fabiola Lucena; Carvajal, Francisco Martín; Adán, Norberto Gándara; Bautista, Maximino Redondo; Osinaga, J. Abilés

doi:10.1007/s11695-016-2445-0

Cited by 18 publications

(13 citation statements)

References 60 publications

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“…In the present study, the prevalence of vitamin D deficiency (13.3%) was lower than an observational study carried out in the city of Rio de Janeiro, in which the prevalence in adults with class III obesity was 35.3% [26]. Our prevalence was also lower than the Spanish study with adults with a BMI ≥ 40 kg/m 2 (50.7%) [28] and a study with patients in the pre-operative period of bariatric surgery (72%) [27]. The lower prevalence observed in the present study can be justified by the higher incidence of sunlight in the Brazilian Midwest region where the study was conducted.…”

Section: Discussioncontrasting

confidence: 63%

“…Only the low HDL cholesterol was associated as a protective factor for serum vitamin D deficiency. Therefore, our main findings bring important contributions to this research area, which has not been much studied, with conflicting results [27,28].…”

Section: Discussionmentioning

confidence: 87%

“…A study carried out with 73 Caucasian adults showed an association between hypovitaminosis D and MS in individuals with severe obesity [28]. On the other hand, another study with adults with severe obesity (mean BMI of 45 kg/m 2 ) found no significant association between MS parameters and serum vitamin D levels before undergoing bariatric surgery [27]. Therefore, the association between vitamin D deficiency and MS in this group is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…However, in individuals with severe obesity, there are still few studies analyzing vitamin D deficiency and MS, with conflicting results [26][27][28][29]. In adults with class III obesity (BMI ≥ 40 kg/m 2 ), there was a negative correlation between BMI and vitamin D [26].…”

Section: Introductionmentioning

confidence: 99%

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Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

et al. 2021

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The association between vitamin D deficiency and metabolic syndrome (MS) in severe obesity is unclear and controversial. We analyzed serum and dietary vitamin D and their association with MS in 150 adults with class II and III obesity (BMI ≥ 35 kg/m2) from the DieTBra Trial (NCT02463435). MS parameters were high fasting blood glucose, low HDL cholesterol, high triglycerides, elevated waist circumference, and hypertension. Vitamin D deficiency was considered as a level < 20 ng/mL. We performed multivariate Poisson regression adjusted for sociodemographic and lifestyle variables. The prevalence of serum vitamin D deficiency was 13.3% (mean 29.9 ± 9.4 ng/mL) and dietary vitamin D median was 51.3 IU/day. There were no significant associations between vitamin D, serum, and diet and sociodemographic variables, lifestyle, and class of obesity. Serum vitamin D deficiency was associated with age ≥ 50 years (p = 0.034). After a fully adjusted multivariate Poisson regression, MS and its parameters were not associated with serum or dietary vitamin D, except for lower HDL, which was associated with serum vitamin D deficiency (PR = 0.71, 95% CI 0.52–0.97; p = 0.029). Severe obese individuals had a low prevalence of vitamin D deficiency, which was not associated with MS.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

et al. 2021

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“…It is the most prevalent micronutrient deficiency in the world, with a billion people estimated to be deficient [4]. Individuals with obesity, including those suffering from liver disease, are more susceptible to VDD [5]. A potential explanation for this deficiency is, when there is damage of the liver, synthesis of 25(OH)D may be impaired by the presence of steatosis.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Cordeiro

Pereira

Saboya³

et al. 2017

Canadian Journal of Gastroenterology and Hepatology

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Aim To evaluate the relationship of nonalcoholic fatty liver disease (NAFLD) with nutritional status of vitamin D in extreme obesity. Methods Descriptive cross-sectional study in individuals with class III obesity (BMI ≥ 40 kg/m2), aged ≥ 20 years to < 60 years. Data were obtained for weight, height, waist circumference (WC), and serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D analysis was performed by high performance liquid chromatography (HPLC) and the cutoff points used for its classification were < 20 ng/mL for deficiency and 20–29.9 ng/ml for insufficiency. NAFLD gradation was conducted through histological evaluation by liver biopsy. Results The sample is comprised of 50 individuals (86% female). BMI and average weight were 44.1 ± 3.8 kg/m2 and 121.4 ± 21.4 kg, respectively. Sample distribution according to serum 25(OH)D levels showed 42% of deficiency and 48% of insufficiency. The diagnosis of NAFLD was confirmed in 100% of the individuals, of which 70% had steatosis and 30% had steatohepatitis. The highest percentage of 25(OH)D insufficiency was seen in individuals with steatosis (66%/n = 21) and steatohepatitis (93%/n = 16). All individuals with steatohepatitis presented VDD (p < 0.01). Conclusion The results of this study showed high prevalence of serum 25(OH)D inadequacy in individuals with class III obesity, which worsens as the stage of liver disease progresses.

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Perioperative and Postoperative Guidance of the Bariatric Patient

Mathus-Vliegen

Dargent²

2018

Bariatric Therapy

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Relationship Between Vitamin D Deficiency and the Components of Metabolic Syndrome in Patients with Morbid Obesity, Before and 1 Year After Laparoscopic Roux-en-Y Gastric Bypass or Sleeve Gastrectomy

Abstract: There is a relationship between VDD and persistence of MS, and particularly so with T2DM. VDD could represent a predictor of MS persistence at 12 months after surgery.

Cited by 18 publications

References 60 publications

Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome

Relationship between Nonalcoholic Fatty Liver Disease and Vitamin D Nutritional Status in Extreme Obesity

Perioperative and Postoperative Guidance of the Bariatric Patient

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