Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature

Wang, W; Xp, Luo; Lx, Cai; Zr, Cui; Xy, Luo; Rk, Luo

doi:10.4238/2015.september.8.12

Cited by 6 publications

(8 citation statements)

References 22 publications

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“…25-(OH)D has long been existed in the body and good stability, so it is currently considered to be an important indicator reflecting the vitamin D level of the body. This indicator can regulate the metabolism of calcium and phosphorus in the human body and promote calcium absorption and reabsorption, as well as bone deposition, and has a positive effect on the maintenance of bone health [ 8 ]. IGF-1, a single-chain polypeptide, is mainly produced by the liver, skeletal muscle, and many other tissues in response to growth hormone (GH) stimulation.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature

Zhang

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To discuss the influence of high-dose recombinant human growth hormone (rhGH) therapy on serum vitamin D and insulin-like growth factor-1 (IGF-1) levels in school-age children with idiopathic short stature (ISS). Method. A total of 103 school-age children with ISS were selected from June 2016 to June 2020 in our hospital. The enrolled cases were divided into the low-dose group (n = 59) and high-dose group (n = 44) according to the treatment dose of rhGH. After the treatment, the height (Ht), height standard deviation score (Ht SDS), growth velocity (GV), and other indicators were recorded. The serum 25-hydroxy vitamin D [25-(OH)D] and IGF-1 levels of the two groups were tested, and the occurrence of adverse reactions was recorded. Results. After treatment, the high-dose group outperformed the low-dose group in various growth effect indicators such as Ht, Ht SDS, and GV ( P < 0.05 ). After treatment, the serum 25-(OH)D of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups ( P > 0.05 ). After treatment, the serum IGF-1 of children with ISS in the two groups increased significantly, but there was no significant difference between the two groups ( P > 0.05 ). For children with ISS, adverse reactions induced by rhGH therapy were very rare. There was no significant difference in the incidence of adverse reactions induced by different doses of rhGH in the treatment of ISS ( P > 0.05 ). Conclusion. rhGH has definite efficacy in the treatment of ISS children, for it can significantly increase the annual growth rate of ISS children in a dose-dependent manner. High-dose rhGH for ISS has a better therapeutic effect. At the same time, regardless of the dose level of rhGH, serum 25-(OH)D and IGF-1 levels in children with ISS were increased, with less adverse reactions and higher safety.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature

Zhang

Xie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…It is concluded that deficiency of vitamin D may affect IGF-1 level in children and adolescents exhibiting deficiency of growth hormones like IGF-1 [ 146 ]. VDR polymorphism has also been associated with idiopathic short stature in several studies [ 23 ].…”

Section: Anabolic Steroids and Growth Hormonesmentioning

confidence: 99%

“…In a study conducted on a Chinese population, it was observed that polymorphism in VDR rs2228570a and DBP rs7041 are more responsible for higher susceptibility to hepatitis B virus related HCC [ 22 ]. Recent published trials showing the association between vitamin D and HCC have been documented in Table 3 .VDR polymorphism is also associated with idiopathic short stature in several studies [ 23 ]. Recently, Marek et al has conducted an important study linking growth hormone (IGF-1 axis), Vitamin D and bone mineral density (BMD) in patients afflicted with chronic viral hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

et al. 2018

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BackgroundLiver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too.ResultEpidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise.ConclusionThe anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer.

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“…Cxcl12 (C‐X‐C motif chemokine 12), also called SDF1, is the ligand for GPCR, which plays a role in calcium regulation. Vitamin D receptor is essential in the metabolism of minerals, especially calcium (51). Gremlin 1, a biomarker of osteochondroreticular stem cells in the bone marrow, was decreased after PFMG1 treatment, which indicates a loss of stem cell features during osteoblast differentiation (52).…”

Section: Discussionmentioning

confidence: 99%

PFMG1 promotes osteoblast differentiation and prevents osteoporotic bone loss

Wang

et al. 2018

FASEB j.

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Nacre is a widely used mineral medicine that has been reported to have beneficial effects in bone remodeling without an increase in inflammation. Water-soluble nacre matrix has been demonstrated to be responsible for the effect, yet core active ingredients are unknown. Pinctada fucata mantle gene 1 (PFMG1) was first discovered in the mantle tissue of Pinctada fucata. The protein has 2 EF-hands, a calcium-binding domain. PFMG1 protein can affect the growth of calcium carbonate crystals in vitro. Here, we demonstrate that PFMG1 affects cell-cycle distribution and promotes preosteoblast proliferation. PFMG1 accelerates preosteoblast differentiation and extracellular matrix mineralization. During the differentiation process, PFMG1 increases the expression level of osteoblastic marker genes and activates the Erk signaling pathway. PFMG1 also accelerates calcium crystal aggregation in culture medium and suppresses osteoclast formation. Moreover, PFMG1 prevents bone loss caused by ovariectomy. RNA sequencing analysis demonstrated that PFMG1 stimulates genes that are associated with tissue development and ossification, which indicated new genes that function in bone remodeling. Our findings demonstrate the therapeutic potential of PFMG1 from nacre as a novel medicine for osteoporosis.-Li, L., Wang, P., Hu, K., Wang, X., Cai, W., Ai, C., Liu, S., Wang, Z. PFMG1 promotes osteoblast differentiation and prevents osteoporotic bone loss.

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Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature

Cited by 6 publications

References 22 publications

Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature

Analysis of the Influence of High-Dose rhGH Therapy on Serum Vitamin D and IGF-1 Levels in School-Age Children with Idiopathic Short Stature

Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D

PFMG1 promotes osteoblast differentiation and prevents osteoporotic bone loss

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