Relationship Between Vitamin D Status and Brain Perfusion in Neuropsychiatric Lupus

Sultana, Nasreen; Sarker, Azmal Kabir; Ihsan, Md. Amimul; Haq, Syed Atiqul; Arefin, Md Saidul; Islam, Sheikh Nazrul

doi:10.1007/s13139-022-00741-x

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…underlines the importance of investigating its serum levels, together with supplementation until the necessary optimal values are obtained. This desire resides from the objectification of the correlation between the hypoperfusion of the cognitive areas of the brain found, the neuro-psychic manifestations characteristic of lupus and hypovitaminosis D ( 103 ).…”

Section: Is Hypovitaminosis D An Alternative Therapeutic Target In Psle?mentioning

confidence: 99%

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

Lupu,

Jechel

et al. 2024

Front. Immunol.

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Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to the numerous researches aimed at its interactions with the body’s homeostasis. At the same time, there is a peak in terms of recommendations for supplementation with it. Some of the studies focus on the link between autoimmune diseases and nutritional deficiencies, especially vitamin D3. Since the specialized literature aimed at children (patients between 0-18 years old) is far from equal to the informational diversity of the adult-centered branch, this review aims to bring up to date the relationship between the microbial and nutritional balance and the activity of pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides in a better understanding and an adequate, individualized management of the affected persons to reduce morbidity. The center of the summary is to establish the impact of hypovitaminosis D in the development and evolution of pediatric lupus erythematosus. We will address aspects related to the two entities of the impact played by vitamin D3 in the pathophysiological cascade of lupus, but also the risk of toxicity and its effects when the deficiency is over supplemented (hypervitaminosis D). We will debate the relationship of hypovitaminosis D with the modulation of immune function, the potentiation of inflammatory processes, the increase of oxidative stress, the perfusion of cognitive brain areas, the seasonal incidence of SLE and its severity. Finally, we review current knowledge, post-pandemic, regarding the hypovitaminosis D – pSLE relationship.

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Section: Is Hypovitaminosis D An Alternative Therapeutic Target In Psle?mentioning

confidence: 99%

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

Lupu,

Jechel

et al. 2024

Front. Immunol.

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What is known about the effects of vitamin D in neuropsychiatric lupus?

Karnopp,

da Silva Freitas,

Di Domenico

et al. 2024

Adv Rheumatol

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Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE. Graphical abstract

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Relationship Between Vitamin D Status and Brain Perfusion in Neuropsychiatric Lupus

Cited by 2 publications

References 51 publications

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

What is known about the effects of vitamin D in neuropsychiatric lupus?

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