Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Abstract

ABSTRACT. Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-tosevere OSA. This case-control study aims to investigate the relationship between genetic variations in the ZFP36 gene and moderate-to-severe OSA. Three common single nucleotide polymorphisms of the ZFP36 gene (rs251864, rs3746083, and rs17879933) were evaluated in a group of patients with moderate-to-severe OSA (N = 408) and in a control Y. Zhang et al. 6734©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6733-6743 (2015) group (N = 394) by using TaqMan polymerase chain reaction analysis. The moderate-to-severe OSA group and the control group exhibited significant differences in the distributions of rs251864 and rs17879933 genotypes and alleles (P < 0.05). TNF-α levels were significantly different not only among the three rs251864 genotypes but also between the II genotype and the DD + ID genotypes of rs17879933. However, no significant differences in sleep apnea parameters in the three ZFP36 gene polymorphisms were observed. Logistic regression analyses demonstrated that TNF-α and the three ZFP36 gene polymorphisms were not independently associated with OSA. ZFP36 might be involved in TNF-α regulation. However, ZFP36 gene variants were not independent risk factors for moderate-to-severe OSA.

Unraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis

“…In addition, two crucial ferroptosis genes, CD44 and ZFP36, experimentally validated, exhibited a positive correlation with macrophages, with CD44 showing a particularly strong association. ZFP36, namely zinc finger protein 36, exerts an influence on the stability of TNF-α mRNA and a recent study has revealed that the disruption of ZFP36 in mice led to the development of a multifaceted inflammatory syndrome due to elevated TNF-α production [42] and further attracts macrophage infiltration. In this study, we first revealed ZFP36 protein expression were downregulated in DKD kidney tissues and in podocyte MPC5 and mesangial SV40-MES-13 cells after HG stimulation,while the downregulation of ZFP36 can trigger the activation of ferritinophagy and the initiation of ferroptosis [43].…”

Identification of Markers for Diagnosis and Treatment of Diabetic Kidney Disease Based on the Ferroptosis and Immune

“…Similarly, ZFP36 obtained from model screening is a zinc finger protein affecting TNF- α mRNA's stability. Zhang et al found that the inactivation of ZFP36 in mice resulted in a complex inflammatory syndrome caused by increased TNF- α production [ 35 ]. Some studies have reported that the level of ZFP36 in diabetic patients was significantly lower than in controls.…”

The Discovery, Validation, and Function of Hypoxia-Related Gene Biomarkers for Obstructive Sleep Apnea

“…Recent data have indicated that inflammation may play an important role in OSA ( 44 ). Zhang et al found that the genotype distribution of single nucleotide polymorphisms rs251864 and rs17879933 in ZFP36 were significantly different between moderate-to-severe OSA patients and control controls, but they were not directly associated with sleep apnea parameters, suggesting that ATF may be involved in regulating OSA in cooperation with other factors ( 45 ). It has also been reported that overnight IH in patients with OSA induces expression of DUSP1 , which may mediate increases in manganese superoxide dismutase (MnSOD) expression and activity, contributing significantly to neutralizing the effects of the ROS elicited by OSA ( 46 ).…”