Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis

Sağ, Sinem; Nas, Kemal; Sağ, Mustafa Serdar; Tekeoğlu, İbrahim; Kamanlı, Ayhan

doi:10.3233/bmr-169657

Cited by 30 publications

(31 citation statements)

References 22 publications

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“…Age, ethnicity, disease duration, disease activity, function, quality of life and current NSAID use were included in all multivariable analyses as they were significant in at least one univariable analysis. Some of these factors – age, ethnicity, disease duration, disease activity and function – were reported to significantly affect work outcomes in other studies as well.…”

Section: Resultsmentioning

confidence: 85%

“…Studies in axSpA and ankylosing spondylitis populations have previously shown that increased disease activity was associated with presenteeism and activity impairment . Other studies have demonstrated that decreased physical function was associated with work productivity loss and activity impairment, and poorer quality of life with absenteeism, presenteeism, work productivity loss and activity impairment …”

Section: Discussionmentioning

confidence: 98%

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A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

et al. 2019

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Aim: Axial spondyloarthritis (axSpA) affects patients in the prime of their economic productivity. We aim to identify factors associated with poor work productivity in patients with axSpA in Singapore. Methods:A cross-sectional study was performed in two tertiary centers in Singapore. Consecutive adult patients ≥21 years fulfilling Assessment in SpondyloarthritisInternational Society (ASAS) 2009 criteria for axSpA were recruited. Data on social demographics, clinical, treatment modalities and patient-reported outcome measures (PROMs) were collected. Work productivity was assessed by the Work Productivity and Activity Impairment scale (WPAI:SpA). Factors associated with presenteeism, absenteeism, work productivity loss and activity impairment were evaluated. Results:A total of 156 patients with axSpA were included: 72.4% employed, 80.1% male, 86.5% Chinese, median (Q1:Q3) age and duration of illness 36.7 (28.7:47.9) years, and 6.3 (1.6:12.2) years respectively. The mean (SD) activity impairment was 28.2% (24.3%). Among employed patients, mean (SD) absenteeism, presenteeism and work productivity loss was 4.

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Section: Resultsmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 98%

A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

et al. 2019

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“…TNF-α, with an intensive biological effect, is regarded as the most important factor in the development of AS and proven to be positively associated with disease activity [32,33]. We suggested the poor nutrition might also attributed to psychological disorders [12,34]. The global function might be affected after long-term low nutritional condition and inflammatory cytokine activation.…”

Section: Discussionmentioning

confidence: 94%

“…Disease activity pointing to a feature of inflammation is believed to potentially affect the multi-system functions in AS. Significant correlations were found between work productivity, daily activity, psychological status and disease activity [11,12]. Furthermore, disease activity was suggested as an increased risk of mortality [13], which might be associated with the impairment of cardiovascular system, coagulation-fibrinolytic system and microvascular function [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Active ankylosing spondylitis increases blood loss during total hip arthroplasty for a stiff hip joint

Jiang

Pan

et al. 2020

BMC Musculoskelet Disord

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Background: Total hip arthroplasty (THA) has been highlighted as the best treatment option for ankylosing spondylitis (AS) patients with advanced hip involvement. The huge blood loss associated with THA is a common concern of postoperative complications. Disease activity is a specific reflection of systematic inflammation of AS. The purpose of this study was to determine the effect of disease activity on blood loss during THA in patients with AS. Methods: Forty-nine patients with AS who underwent unilateral THAs were retrospectively studied. Ankylosing Spondylitis Disease Activity Score (ASDAS) was employed to evaluate the disease activity. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) formula was used to assess the surgical blood loss. The patients were divided into active group (ASDAS≥1.3; n = 32) and stable groups (ASDAS< 1.3; n = 17) based on the ASDAS. Peri-operative laboratory values, plain radiographs, intra-operative data, transfusion volume, and use of hemostatic agents were recorded and statistically analyzed. Results: The ASDAS, pre-operative C-reactive protein level, erythrocyte sedimentation rate, and fibrinogen concentration in the active group were higher than the stable group (all P < 0.05); however, the pre-operative hemoglobin concentration and albumin level were higher in the stable group (both P < 0.05). The total blood loss during THA in stable patients was 1415.31 mL and 2035.04 mL in active patients (P = 0.006). The difference between the two groups was shown to be consistent after excluding the gender difference (P = 0.030). A high transfusion rate existed in both groups (stable group, 76.47% with an average of 1.53 units; active group, 84.37% with an average of 2.31 units), but there was no significant difference between the two groups (both P > 0.05). Compensated blood loss, corresponding to transfusion, was noted significantly more in the active group compared to the stable group (P = 0.027). There was no significant difference with regard to functional recovery (P > 0.05). Conclusion: Active AS patients are at high risk for increased blood loss during THA compared to stable patients. The underlying mechanism includes disorders of the coagulation and fibrinolytic systems, poor nutrition status, osteoporosis, imbalance of oxidative-antioxidative status and local inflammatory reaction. It is strongly recommended to perform THA in AS patients with stable disease.

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“…TNF-α, with an intensive biological effect, is regarded as the most important factor in the development of AS and proven to be positively associated with disease activity (32,33). We suggested the poor nutrition might also attributed to psychological disorders (12,34). The global function might be affected after long-term low nutritional condition and inflammatory cytokine activation.…”

Section: Discussionmentioning

confidence: 92%

Active Ankylosing Spondylitis Increases Blood Loss during Total Hip Arthroplasty for a Stiff Hip Joint

Jiang

Pan

et al. 2020

Preprint

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Background: Total hip arthroplasty (THA) has been highlighted as the best treatment option for ankylosing spondylitis (AS) patients with advanced hip involvement. The huge blood loss associated with THA is a common concern of postoperative complications. Disease activity is a specific reflection of systematic inflammation of AS. The purpose of this study was to determine the eﬀect of disease activity on blood loss during THA in patients with AS. Methods: Forty-nine patients with AS who underwent unilateral THAs were retrospectively studied. Ankylosing Spondylitis Disease Activity Score (ASDAS) was employed to evaluate the disease activity. Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) formula was used to assess the surgical blood loss. The patients were divided into active group (ASDAS≥1.3; n=32) and stable groups (ASDAS<1.3; n=17) based on the ASDAS. Peri-operative laboratory values, plain radiographs, intra-operative data, transfusion volume, and use of hemostatic agents were recorded and statistically analyzed. Results: The ASDAS, pre-operative C-reactive protein level, erythrocyte sedimentation rate, and fibrinogen concentration in the active group were higher than the stable group (all P<0.05); however, the pre-operative hemoglobin concentration and albumin level were higher in the stable group (both P<0.05). The total blood loss during THA in stable patients was 1415.31 mL and 2035.04 mL in active patients (P=0.006). The difference between the two groups was shown to be consistent after excluding the gender difference (P=0.030). A high transfusion rate existed in both groups (stable group, 76.47% with an average of 1.53 units; active group, 84.37% with an average of 2.31 units), but there was no significant difference between the two groups (both P >0.05). Compensated blood loss, corresponding to transfusion, was noted significantly more in the active group compared to the stable group (P=0.027). There was no significant difference with regard to functional recovery (P>0.05). Conclusion: Active AS patients are at high risk for increased blood loss during THA compared to stable patients. The underlying mechanism includes disorders of the coagulation and fibrinolytic systems, poor nutrition status, osteoporosis, imbalance of oxidative–antioxidative status and local inflammatory reaction. It is strongly recommended to perform THA in AS patients with stable disease.

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Relationship of work disability between the disease activity, depression and quality of life in patients with ankylosing spondylitis

Abstract: In this study, we determined that AS had a significant influence on the working conditions and the factors related to the disease had a significant correlation with work productivity. Factors related to the psychology and the disease were also correlated with the working conditions.

Cited by 30 publications

References 22 publications

A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

A cross‐sectional study on factors associated with poor work outcomes in patients with axial spondyloarthritis in Singapore

Active ankylosing spondylitis increases blood loss during total hip arthroplasty for a stiff hip joint

Active Ankylosing Spondylitis Increases Blood Loss during Total Hip Arthroplasty for a Stiff Hip Joint

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