“…Other factors impacting generalizability include sample size and missing data, which is a limitation in itself. 14,18,20,23,27,28,[32][33][34]38,40,50,53,55,[57][58][59][60][61][62]64,[66][67][68][69][70][71] In addition, certain variable groups such as ''race'' were under-or over-representative of the U.S. population overall, therefore serving as a limitation to generalizability in results due to the unequal representation of groups within variables. 60 In many studies, cohorts were dichotomized into sub-cohorts based on specific thresholds 21,23,[28][29][30][31]34,37,41,45,55,60,61,68,69,72,73 ; therefore caution is required when applying these findings to a more general population.…”