Relationships between FSH patterns and follicular dynamics and the temporal associations among hormones in natural and GnRH-induced gonadotropin surges in heifers

Haughian, James M.; Ginther, O.J.; Kot, Karolina; Wiltbank, Milo C.

doi:10.1530/rep.1.00030

Cited by 60 publications

(31 citation statements)

References 21 publications

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“…The close temporal relationship between the three hormones has been previously reported for single ovulators (Bergfelt et al 1997, Haughian et al 2004). An apparently unreported observation in cattle was a reduction or cessation in the diameter increase for F1 in both single and double ovulators and for F2 in double ovulators beginning at the synchronised LH, FSH and E 2 peaks.…”

Section: Discussionsupporting

confidence: 78%

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Follicle and hormone dynamics in single versus double ovulating heifers

Palhão¹,

Beg²,

Rodrigues³

et al. 2009

Reproduction

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Follicles R5 mm were ablated at 4 day post-ovulation in heifers to induce a follicular wave, and prostaglandin F 2a was given at day 6 to increase the incidence of double ovulations. Follicle diameters and plasma hormone concentrations were compared between single ovulators (nZ12) and double ovulators (nZ8). In double ovulators, the interval from follicle deviation to the peak of the pre-ovulatory LH surge was shorter (1.9G0.2 vs 2.5G0.2 days; P!0.02) and diameter of the largest pre-ovulatory follicle was smaller (12.2G0.5 vs 13.3G0.3 mm; P!0.02). The LH concentrations of the pre-ovulatory surge did not differ between single and double ovulators for 24 h on each side of the peak. When data were normalised to LH peak, the peak of the pre-ovulatory FSH and oestradiol (E 2 ) surges occurred in synchrony with the peak of LH surge for both groups. Concentration of FSH for 24 h on each side of the peak showed a group effect (P!0.0001) from lower concentration in the double ovulators. A group-by-hour interaction (P!0.008) for E 2 reflected greater concentration in the double ovulators before and at the peak. Results indicated that two pre-ovulatory follicles resulted in an earlier and greater E 2 increase, leading to lower FSH concentration, an earlier LH surge, and ovulation at a smaller diameter. In conclusion, the difference in hormone concentrations during the pre-ovulatory period was an effect rather than a cause of double ovulations.

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Section: Discussionsupporting

confidence: 78%

“…The pre-ovulatory and periovulatory FSH surges were defined as the surges temporally related to the LH surge and to ovulation respectively, as described (Haughian et al 2004). The first nadir for an FSH surge was the lowest value preceding the progressive increase in concentrations.…”

Section: Definitions and Experimental Groupsmentioning

confidence: 99%

Follicle and hormone dynamics in single versus double ovulating heifers

Palhão¹,

Beg²,

Rodrigues³

et al. 2009

Reproduction

Self Cite

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“…In contrast, FSH and LH reach a peak simultaneously 1 day before ovulation in women (Reddi et al 1990). Similar relationships between FSH and LH peaks on the day before ovulation occur in cattle (Haughian et al 2004). The periovulatory oestradiol peak occurs 1 or 2 days before ovulation in mares or 2 or 3 days before the LH peak (Ginther 1992).…”

Section: Introductionmentioning

confidence: 93%

Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study

Ginther¹,

Beg²,

Gastal³

et al. 2005

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Changes in systemic concentrations of FSH, LH, oestradiol and progesterone during the ovulatory follicular wave were compared between 30 mares and 30 women. Based on a previous study, the emergence of the future ovulatory follicle was defined as occurring at 13.0 mm in mares and 6.0 mm in women, and deviation in diameter between the two largest follicles was expected to begin at 22.7 mm in mares and 10.3 mm in women. Mean FSH concentrations were high in mares during the luteal phase, resulting from statistically identified FSH surges occurring in individuals on different days and in different numbers (mean, 1.5 6 0.2 surges/mare); the internadir interval was 3.9 6 0.3 days. In contrast, mean FSH in women was low during the luteal phase and increased to a prolonged elevation during the follicular phase. The prolonged elevation was apparent in each individual (internadir interval, 15.2 6 0.4 days). Changes in LH or oestradiol concentrations encompassing deviation were not detected in mares, but both hormones increased slightly but significantly between emergence and deviation in women. The hypothesis that a greater number of growing follicles causes a greater predeviation decrease in FSH was supported for mares (r, 2 0.39; P < 0.04), but a similar negative correlation (r, 20.36) was not significant in women. The hypothesis that the increase in oestradiol during the luteal phase in women was at least partly attributable to luteal-phase anovulatory follicular waves was not supported. Normalization of FSH concentrations to the day of emergence showed maximum value on the day of emergence with a significant increase and decrease on each side of emergence in both species. The day of expected deviation occurred 3 days after emergence during the decline in FSH in both species. These results indicated that the previously reported striking similarities in emergence and deviation between mares and women during the ovulatory follicular wave are associated with species similarities in the temporal relationships between follicle events and FSH concentration changes. Thus, mares may be useful research models for studying the role and mechanism of the action of FSH in emergence and deviation during the ovulatory follicular wave in women.

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“…Such increase in recruited follicles at no-CL groups may be attributed to the difference of FSH secretion pattern in the 2 groups. In D1 protocol, FSH had 2 surges; preovulatory surge which associated with the ovulatory LH surge and periovulatory surge which associated with the follicle emergence [16]. In contrast, no-CL group and because of the follicle aspiration, FSH probably had one surge only, which may be higher than that of the D1 protocol.…”

Section: Discussionmentioning

confidence: 85%

No-CL Superstimulatory Protocol: Developing a New Superovulation Treatment Initiated in the Absence of Corpus Luteum (CL) and Compared with D1 and Traditional Superovulation in Cattle

El-Sherry¹,

Matsui²,

Kida³

et al. 2012

TORSJ

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Abstract:The objective of this study was to investigate the effectiveness of superovulation under a complete absence of the Corpus luteum (CL) and compare it with D1 protocol and traditional superovulation in cattle. Animals were divided into three groups as following; 1-D1-protocol: Animals (n= 7) were leaved to get natural ovulation (D0), then received FSH for the next 4 days of the cycle. GnRH was given 12h after the last dose of FSH. 2-No-CL superovulation protocol: Animals (n=10) were synchronized and received PGF2α at D9 or D10 then classified to two subgroups (D9-sub-group and D10-sub-group). After 36 h, all follicles (≥ 5 mm) were aspirated (D0). 3-Control: Animals (n=3) were submitted to the conventional superovulation protocol. Blood samples were collected daily for 13 days. Progesterone (P 4 ) and Estradiol (E 2 ) in plasma were measured by Enzyme immune assay (EIA).The results showed that the number of growing follicles was significantly (P< 0.05) higher in both D9 and D10 subgroups in comparison to the D1 protocol (25.8 ± 4.3 and 20 ± 1.9 vs. 10.9 ± 1.9 respectively). While the number of ovulated follicle was higher in D9 sub-group than D10 sub-group, D1 protocol and control (13.8 ± 4.4 vs. 7.6 ± 3.5, 6.8 ± 1.5 and 9.7±0.9).In conclusion, the superovulation protocol with complete absent of the CL produced high number of growing follicles, decreased variability and considered as a promising superovulation protocol.

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Relationships between FSH patterns and follicular dynamics and the temporal associations among hormones in natural and GnRH-induced gonadotropin surges in heifers

Cited by 60 publications

References 21 publications

Follicle and hormone dynamics in single versus double ovulating heifers

Follicle and hormone dynamics in single versus double ovulating heifers

Systemic concentrations of hormones during the development of follicular waves in mares and women: a comparative study

No-CL Superstimulatory Protocol: Developing a New Superovulation Treatment Initiated in the Absence of Corpus Luteum (CL) and Compared with D1 and Traditional Superovulation in Cattle

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