Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer

Park, Jun‐Ook; Jung, Chan Kwon; Sun, Dong‐Il; Joo, Young Hoon

doi:10.1007/s00405-010-1478-6

Cited by 15 publications

(7 citation statements)

References 13 publications

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“…In contrast, MTA1 expression in NSCLC (61/96, 63.5%) was significantly higher than that in adjacent normal lung tissues. Analyses of various tumor tissues have also found overexpression of MTA1 mRNA, or protein is correlated positively with the extent of tumor invasion or lymph node metastasis [7,[19][20][21]. Consistent with our research, its expression was can promote tumor cell proliferation, survival, migration/ invasion, and tumor angiogenesis and thus serves as a potent carcinogen.…”

Section: Discussionsupporting

confidence: 90%

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

et al. 2011

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Metastasis tumor antigen 1 (MTA1), a novel candidate metastasis-associated gene, is known to increase the migration and invasion of various tumor cells in vitro. Expression of MTA1 has been shown to be closely correlated with aggressiveness in a variety of human cancers including non-small cell lung cancer (NSCLC). Cigarette smoke is the most established risk for lung carcinogenesis; however, its effects on the progression of NSCLC are still unclear. In this study, we investigated MTA1 expression and analyzed its association with cigarette smoke in NSCLC by immunohistochemistry. To gain a deeper insight into the molecular mechanism underlying the relation between MTA1 and cigarette smoke, we treated the NSCLC cell lines with cigarette smoke extract (CSE). MTA1 mRNA levels and proteins were detected in NSCLC cell lines via reverse transcriptase-polymerase chain reaction (RT-PCR) and western blot analysis. Matrigel invasion assay was performed to evaluate cell invasive ability with the treatment of CSE. Immunohistochemical analysis showed MTA1 expression in NSCLC (61/96, 63.5%) was higher than that in adjacent normal lung tissues (15/96, 15.6%; p < 0.05). Moreover, it was significantly associated with smoking history (p < 0.05). The results of RT-PCR and western blotting showed the upregulation of MTA1 after the treatment of CSE in NSCLC cell lines. Matrigel invasion assays showed that MTA1 upregulation and cell invasion was accompanied with the treatment of CSE in the NSCLC cell lines. MTA1 expression correlated with cigarette smoke in NSCLC and suggested that it may play an important role in the smoked-related progress of NSCLC.

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Section: Discussionsupporting

confidence: 90%

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

et al. 2011

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“…For exophytic tumors, the measurement was taken from the height of the surface of the adjacent intact mucosa to the deepest point of infiltration 15. Depth of invasion was classified into 2 categories based on a 2 cm cut off, a modification from our prior study 16. The tumor growth pattern at the invasive front was assessed as either cohesive or non-cohesive, the former being a well-defined pushing margin with large tumor islands, and the latter consisting of scattered, small, irregular cords or single tumor cells with a poorly defined infiltrating margin 14,17.…”

Section: Methodsmentioning

confidence: 99%

Histopathologic Predictors of Lymph Node Metastasis and Prognosis in Tonsillar Squamous Cell Carcinoma

et al. 2013

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BackgroundRisk factors for lymph node metastasis in tonsillar squamous cell carcinoma (TSCC) need to be established to determine the degree of surgery required to achieve high curative rates. However, little is known currently about the histopathological features predicting prognosis, specifically in TSCC.MethodsThis study included 53 patients who underwent surgical resection with neck dissection. Clinicopathological factors investigated included age, gender, alcohol use, tobacco consumption, tumor stage, adjacent structure involvement, cell differentiation, squamous dysplasia, in situ carcinoma associated with primary invasive cancer, carcinoma in situ skip lesions, necrosis, invasive front, depth of invasion, and lymphatic, muscle, or perineural invasion.ResultsContralateral cervical metastasis was associated with higher T stages and soft palate invasion. Lymphatic and muscle invasion were associated with ipsilateral cervical metastasis. Advanced T stage, invasion to the base of tongue, and skip lesions were associated with decreased disease-free survival. Advanced T stage and skip lesions were associated with worse overall survival.ConclusionsAdvanced T stage and soft palate invasion may predict a high risk of contralateral nodal metastasis. T stage and skip lesion are worse prognostic factors in TSCC and should be commented in pathology reports.

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“…Park et al reported that MTA1 can be a useful molecular marker to predict lymphatic metastasis in cancer of the tonsil showing immunohistochemical evidence delineating the expression profiles of MTA1 and their associations with lymph node metastasis in tonsil cancer. A significant correlation between the expression of MTA1 and lymph node metastasis along with MTA1 sensitivity of 53.3 % and a specificity of 84.6 % for the identification of cervical metastases was well defined [56]. 5.5 Differential MTA1 localization as a significant indicator for tumour progression Subcellular localization of coregulators always determines the extent of its activity.…”

Section: Tracking Mta1 In Laryngeal Carcinomasmentioning

confidence: 97%

“…Laryngeal carcinoma is strongly inclined to metastasis of the lymph nodes, which decreases both cure and survival rates [55]. Silencing of MTA1 reversed the behaviour of cancer of the larynx suggesting the therapeutic value of MTA1 in cancer treatment [56]. Park et al reported that MTA1 can be a useful molecular marker to predict lymphatic metastasis in cancer of the tonsil showing immunohistochemical evidence delineating the expression profiles of MTA1 and their associations with lymph node metastasis in tonsil cancer.…”

Section: Tracking Mta1 In Laryngeal Carcinomasmentioning

confidence: 98%

Role of MTA1 in head and neck cancers

Marzook

Deivendran

Kumar

et al. 2014

Cancer Metastasis Rev

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Head and neck cancers usually originate in the squamous cells that line the inner mucosal surfaces of the oral and the neck region. These cancers follow multifocal steps for progression that include risk of developing metastasis. Although therapeutics has advanced in the past decades, head and neck cancers continue to cause much morbidity and mortality. Even with the promising effect of targeted therapies, there is a need for a better evaluation of patients with head and neck cancers. Metastasis-associated tumour antigen 1 (MTA1), a chromatin modifier, is found as an integral part of nucleosome remodelling and histone deacetylation (NuRD) complex. MTA1 is a biomarker for several solid tumours, and the overexpression of which have been documented in various cancers such as breast, ovarian, colon, prostrate etc. Interestingly also, a set of head and neck cancers shows MTA1 overexpression. However, recent evidences from clinical data raise a critical question on the role of MTA1 in head and neck cancers. This calls for a detailed review to the role of MTA1 in oral cancer. This review gives a brief account on the existing biological and molecular data in the context of head and neck cancer invasion and metastasis in relation to MTA1.

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Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer

Cited by 15 publications

References 13 publications

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer

Histopathologic Predictors of Lymph Node Metastasis and Prognosis in Tonsillar Squamous Cell Carcinoma

Role of MTA1 in head and neck cancers

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