Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

Lee, Jae Yeun; Kim, Joon Mo; Lee, Kyoung Yong; Lee, Mi Yeon; Park, Ki Ho

doi:10.3390/nu12030878

Cited by 18 publications

(10 citation statements)

References 58 publications

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“…Thiamine has also been shown to reduce the incidence, severity, and intensity of cataracts [ 246 ]. In a study conducted by Lee et al, a connection was found between thiamine intake and a reduction in disease progression for glaucoma patients with normal tension glaucoma [ 247 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…Ideal diet is well supplied with vitamins and minerals. An exceptionally frequent dietary mistake is insu cient intake of vegetables and fruit, which leads to vitamin and mineral de ciencies [34]. Furthermore, a prefered daily diet also includes low-glycaemic index carbohydrate meals, well-known to be an important source of bre.…”

Section: Discussionmentioning

confidence: 99%

“…Lack of complete understanding of the pathogenesis of the disease along with limited e cacy of conservative and surgical treatments have led to the exploration of other factors associated with the development of glaucoma, including the potential role of health and diet related habits. Currently, only a few studies indicate that inadequate nutrition and alcohol consumption may contribute signi cantly to the onset and progression of glaucoma [10,11]. However, the results of these studies are inconclusive, often con icting as well as controversial [3,12,13].…”

Section: Introductionmentioning

confidence: 99%

Nutrition of patients with primary open-angle glaucoma

Olszewska

Pniakowska²,

Kosny

et al. 2023

Preprint

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Objective The aim of the study is to assess the nutrition of patients with glaucoma and the relationship between the adopted nutrition models, the degree of overweight and obesity, and primary open angle glaucoma. Background Glaucoma is a serious eye disease, which, without proper treatment, can lead to total blindness. It affects 70 mln people in the world, and has been defined by WHO (World Health Organization) as significant burden for the 21st century society. Elevated intraocular pressure is the most important factor of occurrence and progression of the disease. Suboptimal health-related behaviors, including inadequate diet of glaucoma patients are suggested as additionalfactors contributing to development of the disease. Material and methods 625 adults aged 45 years or older were enrolled in the study. The study group comprised 312 subjects diagnosed with Primary Open-Angle Glaucoma [POAG], including 238 women [W]- 76% equal to 476 eyes and 74 men [M]- 24% which is 148 eyes. Control group consisted of 313 subjects with no glaucoma diagnosis – including 202 women [W - 64%, 404 eyes] and 111 men [M - 36%, 222 eyes]. General data, including anthropometric indices and Body Mass Index [BMI] [kg/m2], was collected during the interview with the patient including original questionnaire. The daily nutrition of the study subjects was analysed based on the Questionnaire obtained from the Computer Program - Diet 2.0 developed at the National Food and Nutrition Institute in Warsaw. Nutritional value and composition of consumed meals were also assessed. Results The analysis of the obtained data showed changes regarding obesity and diet-related factors between POAG and control group. Below are mentioned most interesting results. Obesity [BMI>30] was found to be significantly more prevalent among subjects with POAG, regardless of gender [p<0,00000]. The distribution of the number of meals consumed per day was statistically significantly different between the POAG and control group [p=0.001321]. The meals of men with glaucoma were found to be richer in saturated [p=0,001] and unsaturated fats [p=0,023] as well as cholesterol [p=0,039] compared to the dishes consumed by men in the control group. Analysis of the components of meals consumed by women in POAG group showed significant differences compared to women in the control group as to both their number and "size" (grammage) of ingredients [p<0,02]. The results showed that women with POAG ate statistically more frequently 3 meals per day, consuming higher amount of ingredients such as cholesterol and animal and vegetable proteins. Total daily energy values consumed by the subjects with glaucoma were higher than in the control group, although statistically significant values were observed only among women with glaucoma [p<0,0001]. The level of energy obtained from fat consumption was higher among both men [p=0,016] and women with glaucoma [p=0,04] than in the control group. The percentage of energy obtained from alcohol consumption was higher among subjects with glaucoma, with statistically significant differences observed only among women [p=0,0044]. Conclusion POAG correlated with inadequate nutrition model and overweight as well as obesity of subjects. The population of patients with glaucoma, unlike the general healthy adult population, was characterized by higher values of: body weight, BMI and total daily energy obtained from meals, as well as different daily meal components, fewer meals consumed, greater energy supply derived from fat compared to protein, lower water intake and larger alcohol ingestion in the female population. Concluding from the results of this research, it is recommended to intensify the education of POAG patients in terms of proper nutrition. Such action may have beneficial impact on prevention, occurrence and modification of the course of POAG. Apparently, further research is needed to determine the role of efficacy and safety of diet modification and nutritional supplementation in the treatment of glaucoma.

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“…In addition to the influence of individual nutrients on the occurrence of glaucoma, the nutritional levels appear to modulate the risk of glaucoma. An association between reduced nutrient intake and low body mass index (<18.5 kg/m 2 ) in women and an increased incidence of NTG in these individuals have been demonstrated [16].…”

Section: Normal Tension Glaucomamentioning

confidence: 99%

Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review

Młynarczyk¹,

Falkowska²,

Micun³

et al. 2022

Preprint

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Glaucoma is one of the most common causes of irreversible vision loss worldwide. It is an insidious disease with a multifactorial pathogenesis. Despite progress in treatment methods, prevention and lifestyle modifications may be useful in slowing the progression of this disease. This systematic review aimed to evaluate the influence of diet, oxidative stress, and disturbances in blood serum levels of nutrients on the incidence and severity of glaucoma based on scientific reports on the role of nutrition in the pathogenesis and course of glaucoma. This paper presents an analysis of the above issues; however, further research is required to develop this topic. Future clinical trials are needed to assess the influence of nutrition and to develop nutritional management strategies for patients with glaucoma.

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Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

Cited by 18 publications

References 58 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutrition of patients with primary open-angle glaucoma

Diet, Oxidative Stress, and Blood Serum Nutrients in Various Types of Glaucoma: A Systematic Review

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