Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

Wu, Shuo‐Jye; Kor, Chew‐Teng; Chen, Tingyu; Liu, Ko-Hung; Shih, Kai-Lun; Su, Wei‐Wen; Wu, Hung‐Ming

doi:10.1155/2019/6859757

Cited by 22 publications

(24 citation statements)

References 42 publications

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“…Our findings are consistent with previous results [46] showing that the subjects with higher inflammatory status (hs-CRP ≥ 3.0 mg/L) had also significantly higher MDA levels and lower antioxidant enzymes activities. This higher MDA levels could derive from the lower plasma antioxidant enzymes and to the over active leukocytes, which are the primary source of ROS in inflammatory disorders such as MetS [47].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

et al. 2020

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“…Duplicate publications, lectures and review articles (n = 58), as well as articles that were not relevant to the subject and did not meet the inclusion criteria (n = 256), were excluded. The remaining 139 studies were screened after reading the full text, and 15 studies were included in the meta-analysis [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. The specific process is shown in Fig 1.…”

Section: Literature Screening Processmentioning

confidence: 99%

“…Oxidative stress is the key link in endothelial dysfunction caused by hyperuricaemia and is related to the increased risk of cardiovascular and cerebrovascular disease [38]. Because uric acid is generally considered to have more harmful than protective effects, it is considered to be a risk factor for CIMT and atherosclerosis [35,36,33], but the clinical relevance of the two has been controversial. Since 1950, research on the relationship between serum uric acid level and carotid intima-media thickness has attracted scholars' attention [39].…”

Section: Plos Onementioning

confidence: 99%

“…By removing each study one by one and calculating the heterogeneity among the remaining studies, we found that the population differences were likely to be the cause of the high heterogeneity. In the 6 studies by Zhigai Zhang 2013 [22], Qin Li 2011 [25], Mustafa Caliskan 2017 [29], Nusret Acikgoz 2011 [31], Yusuf Tavil 2007 [32], and Shun-Sheng Wu 2019 [33], study subjects had type 2 diabetes, hypertension, cardiac syndrome X, and metabolic syndrome (no renal disease or disability), and heterogeneity disappeared when subgroup analysis was performed in these six studies.…”

Section: Plos Onementioning

confidence: 99%

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Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Wang

Huang

et al. 2021

PLoS ONE

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Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for statistical analysis. The standardized mean difference (SMD) and 95% confidence interval (95% CI) were calculated by a random effect model to estimate the correlation. Publication bias was assessed using the Begg and Egger tests. The stability of these results was evaluated using sensitivity analyses. Results Fifteen studies were included with a total sample size of 11382, including 7597 participants in the high uric acid group and 3785 in the control group, on the basis of the inclusion and exclusion criteria. According to the evaluation of the JBI scale, the literature was of high quality. The average age ranged from 42 to 74. Meta-analysis showed that CIMT in the high uric acid group was significantly higher than that in the control group (SMD = 0.53, 95% CI: [0.38, 0.68]), and the difference was significant (z = 6.98, P < 0.00001). The heterogeneity among the 15 articles was obvious (I2 = 89%, P < 0.00001). Subgroup analysis by disease status illustrated a positive relationship between SUA and CIMT in healthy people and people with diseases. SUA was shown to be positively correlated with CIMT in people aged 45–60 years and ≥60 years by subgroup analysis by age. SUA was also found to be positively correlated with CIMT in a population with BMI>24 kg/m2 by subgroup analysis by BMI. In addition, subgroup analysis of other risk factors for CIMT, including TC, SBP, DBP, triglycerides, and LDL-C, all showed a positive correlation between SUA and CIMT. Conclusions There is a significant correlation between serum uric acid level and carotid intima-media thickness, and a high concentration of serum uric acid is related to carotid artery intima-media thickness.

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“…Несмотря на известную связь ТКИМ с активацией РААС [43], хроническим воспалением и окислительным стрессом [44,45], в проведенных нами однофакторном анализе и многофакторном анализе ассоциации ТКИМ с полиморфизмом изучаемых генов и мутантными генотипами выявлено не было (дополнительные материалы, табл. 12-13).…”

Section: результаты и обсуждениеunclassified

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

et al. 2021

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Aim Activation of the renin-angiotensin-aldosterone system, decreased nitric oxide production, chronic inflammation, and oxidative stress result in subclinical changes in the arterial wall, which favor the development of cardiovascular diseases (CVD). The effect of allelic gene variants that encode the proteins participating in pathogenetic pathways of age-associated diseases with subclinical changes in the arterial wall [increased pulse wave velocity (PWV), increased intima-media thickness, endothelial dysfunction (ED), presence of atherosclerotic plaques (ASP)] are understudied. This study analyzed the relationship between AGT, ACE, NOS3 TNF, MMP9, and CYBA gene polymorphism and the presence of subclinical changes in the arterial wall, including the dependence on risk factors for CVD, in arbitrarily healthy people of various age.Material and methods The relationship of polymorphisms с.521С>Т of AGT gene, Ins>Del of AСE gene, с.894G>T of NOS3 gene, – 238G>A of TNF gene, – 1562С>T of MMP9 gene, and c.214Т>С of CYBA gene with indexes of changes in the arterial wall and risk factors for CVD was studied in 160 arbitrarily healthy people by building models of multiple logistic regression and also by analyzing frequencies of co-emergence of two signs with the Pearson chi-squared test (χ2) and Fisher exact test.Results The DD-genotype of Ins>Del ACE gene polymorphism was correlated with increased PWV (p=0.006; odds ratio (OR) =3.41, 95 % confidence interval (CI): 1.48–8.67) and ED (p=0.014; OR=2.60, 95 % CI: 1.22–5.68). The GG genotype of с.894G>T NOS3 gene polymorphism was correlated with ED (p=0.0087; OR=2.65, 95 % CI: 1.26–5.72); the ТТ-genotype of с.894G>T NOS3 gene polymorphism was correlated with ASP (p=0.033; OR=0.034, 95 % CI: 0.001–0.549).Conclusion Polymorphic variants of AСE and NOS3 genes correlated with ED, increased arterial wall stiffness, and the presence of subclinical changes in the arterial wall.

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Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

Cited by 22 publications

References 42 publications

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

Metabolic Syndrome Is Associated with Oxidative Stress and Proinflammatory State

Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness

Association of AGT, ACE, NOS3, TNF, MMP9, CYBA polymorphism with subclinical arterial wall changes

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