Relationships between total/free prostate-specific antigen and prostate volume in Chinese men with biopsy-proven benign prostatic hyperplasia

Mao, Qinan; Zheng, Xiangyi; Jia, Xiaolong; Wang, Yuyong; Qin, Jie; Yang, Kai; Bai, Yongtao; Xie, Liping

doi:10.1007/s11255-009-9533-1

Cited by 23 publications

(32 citation statements)

References 17 publications

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“…The ROC curves revealed that the efficacy of fPSA at predicting threshold prostate sizes (30, 40, and 50 mL) showed AUC ranging from 0.72 to 0.75, denoting better discrimination of PV than that of tPSA [18]. …”

Section: Discussionmentioning

confidence: 99%

Free Prostate-Specific Antigen Provides More Precise Data on Benign Prostate Volume Than Total Prostate-Specific Antigen in Korean Population

et al. 2013

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PurposeTo investigate the efficacy of total prostate-specific antigen (tPSA) and free prostate-specific antigen (fPSA) for the estimation of prostate volume (PV) in pathologically-proven benign prostatic hyperplasia (BPH) patients.MethodsFrom January 2010 to March 2013, 165 Korean men with a PSA less than 10 ng/mL who were diagnosed without prostate cancer by prostate biopsy were enrolled. Patients were classified into three age groups: ≤60, 61-70, and >70 years old. The results were organized to estimate and compare the ability of serum tPSA and fPSA to assess the PV.ResultsEnrolled patients had a median age of 63.5 years (44 to 80), a median tPSA of 5.72 ng/mL, a median fPSA of 0.98 ng/mL and a median PV of 53.68 mL, respectively. Among the associations between tPSA, fPSA, age, and PV, the highest correlation was verified between fPSA and PV (r=0.377, P<0.0001); the correlation coefficient between tPSA and PV was much lower (r=0.262, P<0.001). All stratified age cohorts showed the same findings. The ROC curves (for PV greater than 30, 40, and 50 mL) showed that fPSA (area under the curve [AUC]=0.781, 0.718, and 0.700) outperformed tPSA (AUC=0.657, 0.583, and 0.67) in its ability to predict clinically significant PV enlargement.ConclusionBoth tPSA and fPSA significantly correlated with PV in Korean men, while the correlation efficiency between fPSA and PV was more powerful. fPSA may be a useful tool in making therapeutic decisions and follow-up management in BPH patients.

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Section: Discussionmentioning

confidence: 99%

Free Prostate-Specific Antigen Provides More Precise Data on Benign Prostate Volume Than Total Prostate-Specific Antigen in Korean Population

et al. 2013

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“…Ornstein et al 8 reported that among 70 men with biopsy-proven BPH, %fPSA, but not PSA, was significantly correlated with TPV in patients with PSA levels ranging from 2.6 to 9.9 ng ml 21 , indicating a predictive role of fPSA for TPV. Mao et al 7 reported that fPSA was a more accurate predictor of TPV than PSA in 286 Chinese men with biopsy-proven BPH. In the current study, the correlation coefficient of the formula incorporating PSA and %fPSA with TPV (R50.56) was equal to that of the formula using only fPSA with TPV (R50.56).…”

Section: Discussionmentioning

confidence: 99%

“…This cut-off point has been used in previous studies, not only for Western populations 17,18 but also for Asian populations. 7 Using the TMDU data set, significant and independent predictors of TPVs greater than 40 ml were identified by univariate and multivariate analyses using a backward stepwise logistic regression. Incorporating all of the significant predictors, a logistic regression-based nomogram was developed.…”

Section: Creation Of the Equation For Predicting Prostate Volumementioning

confidence: 99%

“…Moreover, some investigators have reported that free PSA (fPSA) and percent-fPSA (%fPSA) outperform PSA as predictors of prostate enlargement without PCa. [7][8][9] Previous studies have consistently shown that increased adiposity, as determined by various anthropometric measures, such as body weight (BW), 10 body mass index (BMI) [10][11][12] and waist circumference, 10,11 is positively associated with transrectal ultrasound-and with magnetic resonance imaging-measured TPV.…”

Section: Introductionmentioning

confidence: 99%

“…Although there are several predictive models estimating clinical prostatic enlargement based on levels of PSA or PSA derivatives, [6][7][8][9][10][11][12][13] Jacobson et al 13 recently reported that age and weight can be incorporated into models based on serum PSA levels to achieve greater accuracy when estimating TPV. However, predictive models including anthropometric measurements have never been investigated in Asia.…”

Section: Introductionmentioning

confidence: 99%

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A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

Nakanishi

Masuda²,

Kawakami³

et al. 2012

Asian J Androl

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Anthropometric measurements, e.g., body weight (BW), body mass index (BMI), as well as serum prostate-specific antigen (PSA) and percent-free PSA (%fPSA) have been shown to have positive correlations with total prostate volume (TPV). We developed an equation and nomogram for estimating TPV, incorporating these predictors in men with benign prostatic hyperplasia (BPH). A total of 1852 men, including 1113 at Tokyo Medical and Dental University (TMDU) Hospital as a training set and 739 at Cancer Institute Hospital (CIH) as a validation set, with PSA levels of up to 20 ng ml 21 , who underwent extended prostate biopsy and were proved to have BPH, were enrolled in this study. We developed an equation for continuously coded TPV and a logistic regression-based nomogram for estimating a TPV greater than 40 ml. Predictive accuracy and performance characteristics were assessed using an area under the receiver operating characteristics curve (AUC) and calibration plots. The final linear regression model indicated age, PSA, %fPSA and BW as independent predictors of continuously coded TPV. For predictions in the training set, the multiple correlation coefficient was increased from 0.38 for PSA alone to 0.60 in the final model. We developed a novel nomogram incorporating age, PSA, %fPSA and BW for estimating TPV greater than 40 ml. External validation confirmed its predictive accuracy, with AUC value of 0.764. Calibration plots showed good agreement between predicted probability and observed proportion. In conclusion, TPV can be easily estimated using these four independent predictors.

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Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms

Waheed

2016

Men's Health in Primary Care

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Relationships between total/free prostate-specific antigen and prostate volume in Chinese men with biopsy-proven benign prostatic hyperplasia

Cited by 23 publications

References 17 publications

Free Prostate-Specific Antigen Provides More Precise Data on Benign Prostate Volume Than Total Prostate-Specific Antigen in Korean Population

Free Prostate-Specific Antigen Provides More Precise Data on Benign Prostate Volume Than Total Prostate-Specific Antigen in Korean Population

A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms

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