Relationships between tricyclic antidepressant concentrations, 1-3H-noradrenaline uptake and chronotropic effect in isolated rat atria

Pharmacologically Active Drug Metabolites: Impact on Drug Discovery and Pharmacotherapy

“…Doxepin. Doxepin is an unusual agent in that the parent and N-desmethyl metabolite appear to possess very different pharmacological activities (Mundo et al, 1974). Doxepin is a potent antihistamine that readily penetrates the brain and thus causes sedation and is indicated for this purpose at low doses (Silenor, 2010).…”

Peripherally and Centrally Mediated Bradycardiac Effects of Clonidine in Anesthetized or Spinal Rats

“…Moreover, it is surprising that a tachycardia is also caused after a treatment with DMI even in isolated rats atria (Babulova et al 1973;Mundo et al 1974) or vagotomized and spinal rats. DMI is thought to cause a sinus acceleration of in situ canine heart by blocking uptake of catecholamines which are released from the sympathetic nerve terminals (Chiba 1974).…”