Relationships between vitamin D, parathyroid hormone and bone mineral density in inflammatory bowel disease

Silvennoinen, Jouni

doi:10.1046/j.1365-2796.1996.420765000.x

Cited by 91 publications

(73 citation statements)

References 22 publications

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“…In contrast to findings in adults with IBD, 24 we found lower serum 25OHD concentrations in newly diagnosed patients. Our finding of a positive association of serum 25OHD concentration with vitamin D supplementation has not been observed by other investigators of either adults 18,22 or children 18 with IBD.…”

Section: Discussioncontrasting

confidence: 84%

“…27 Decreased oral vitamin D intake in patients with IBD compared with healthy individuals has been neither consistently documented 27 nor linked with low serum 25OHD concentrations. 18,22 Intestinal absorption of vitamin D was found to be normal in the majority of patients with IBD, regardless of the severity of disease. 27,43 Protein-losing enteropathy frequently complicates the course of IBD 44 resulting in hypoalbuminemia.…”

Section: Discussionmentioning

confidence: 99%

“…Serum 25OHD concentrations have been found to be normal in some studies of patients with UC, 33,34 whereas others report serum 25OHD concentrations <12 ng/mL in 15%. 25 In one study, 22 the serum 25OHD concentration was <10 ng/mL in 45% of adult patients with UC and was not different from that in patients with CD.…”

Section: Introductionmentioning

confidence: 92%

“…21-31 Serum 25OHD concentration was found to be <10 ng/mL in 8% to 45% of adults with CD. 21,22,24,26 One study reports a negative relationship among disease duration, Crohn Disease Activity Index, ferritin, C-reactive protein, cholesterol, 24 and 25OHD concentration.…”

Section: Author Manuscriptmentioning

confidence: 99%

“…[21][22][23][24][25][26][27][28][29][30][31] Serum 25OHD concentration was found to be <10 ng/mL in 8% to 45% of adults with CD. 21,22,24,26 One study reports a negative relationship among disease duration, Crohn Disease Activity Index, ferritin, C-reactive protein, cholesterol, 24 and 25OHD concentration. Other studies report that smoking 21 and small bowel resection 30,32 are also negatively correlated with 25OHD concentration, whereas sunlight exposure and nutritional status are positively correlated.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease

Pappa¹,

Gordon

Saslowsky³

et al. 2006

Pediatrics

188

144

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OBJECTIVES-Previous studies of vitamin D status in pediatric patients with inflammatory bowel disease have revealed conflicting results. We sought to report (1) the prevalence of vitamin D deficiency (serum 25-hydroxy-vitamin D concentration ≤15 ng/mL) in a large population with inflammatory bowel disease, (2) factors predisposing to this problem, and (3) its relationship to bone health and serum parathyroid hormone concentration.PATIENTS AND METHODS-A total of 130 patients (8-22 years of age) with inflammatory bowel disease, 94 with Crohn disease and 36 with ulcerative colitis, had serum 25-hydroxyvitamin D, intact parathyroid hormone, and lumbar spine bone mineral density (using dual-energy x-ray absorptiometry) measured at Children's Hospital Boston. RESULTS-The prevalence of vitamin D deficiency was 34.6%. Mean serum 25-hydroxyvitamin D concentration was similar in patients with Crohn disease and ulcerative colitis, 52.6% lower among patients with dark skin complexion, 33.4% lower during the winter months (December 22 to March 21), and 31.5% higher among patients who were taking vitamin D supplements. Serum 25-hydroxy-vitamin D concentration was positively correlated with weight and BMI z score, disease duration, and serum albumin concentration and negatively correlated with erythrocyte sedimentation rate. Patients with Crohn disease and upper gastrointestinal tract involvement were more likely to be vitamin D deficient than those without it. Serum 25-hydroxyvitamin concentration was not associated with lumbar spine bone mineral density z score or serum parathyroid hormone concentration.CONCLUSIONS-Vitamin D deficiency is highly prevalent among pediatric patients with inflammatory bowel disease. Factors predisposing to the problem include having a dark-skin complexion, winter season, lack of vitamin D supplementation, early stage of disease, more severe disease, and upper gastrointestinal tract involvement in patients with Crohn disease. The long-term significance of hypovitaminosis D for this population is unknown at present and merits additional study. Copyright © 2006 by the American Academy of PediatricsAddress correspondence to Helen M. Pappa, MD, MPH, Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115. helen.pappa@childrens.harvard.edu. The authors have indicated they have no financial relationships relevant to this article to disclose. NIH Public Access Author ManuscriptPediatrics. Author manuscript; available in PMC 2011 November 1. Available reports on the vitamin D status of adults with CD place the prevalence of 25OHD concentration ≤15 ng/mL between 22% and 70%, depending on the study. 21-31 Serum 25OHD concentration was found to be <10 ng/mL in 8% to 45% of adults with CD. 21,22,24,26 One study reports a negative relationship among disease duration, Crohn Disease Activity Index, ferritin, C-reactive protein, cholesterol, 24 and 25OHD concentration.Other studies report that smoking 21 and small bowel resection 30,32 are also negativel...

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Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Author Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vitamin D Status in Children and Young Adults With Inflammatory Bowel Disease

Pappa¹,

Gordon

Saslowsky³

et al. 2006

Pediatrics

188

144

View full text Add to dashboard Cite

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Metabolic bone disease in adults with inflammatory bowel disease

Adachi

Rostom

2007

Inflamm Bowel Dis

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Bone loss is seen frequently in those with intlammatory bowel disease (IBD). It appears to be more common in those with Crohn's disease than in those with ulcerative colitis. Corticosteroids play an important role in the development of osteoporosis. The prevalence of osteoporosis in IBD, the ef-fects of corticosteroids on bone metabolism, and treatment options are reviewed. Key Words: Inflammatory bowel disease-Crohn's disease-Ulcerative colitis-osteoporo- sis-Osteomalacia-Corticosteroid-induced osteoporosis.~ .~

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