Relationships between vitamin D status and plasma levels of magnesium and parathormone in healthy young adults in Blida region (Algeria)

Abstract

Introduction. Without magnesium, vitamin D cannot be converted to its biolo- gically active form, a relationship that is often overlooked. Objective. The aim of this study was to estimate the frequency of hypovitaminosis D and that of hypomagnese-mia on the one hand, and to analyze the relationship between vitamin D status, magnesium, and plasma parathormone on the other hand. Population and methods. A retrospective descriptive-analytical,and epidemiological study was conducted on a 112 apparently healthy young adult subjects. For this purpose, bioassays of 25-hydroxy-vitamin D, magnesium and plasma parathormone were performed. Results. The frequency of hypovitaminosis D (serum 25-hydroxyvitamin D  30ng/mL) represented 88.39%. Hypomagnesemia affeted 43.75% of the studied population. A highly significant positive correlation was noted between plasma magnesium levels and vitamin D status of the subjects (R= 0.849; P = 0.000), whereas, a very significant negative correlation was observed between magnesium and plasma parathormone levels (R=-0.92 ; P = 0.000). Conclusion. A high frequency of hypovitamin D, a significant frequency of hypomagne-semia, and a positive correlation between plasma magnesium and vitamin D status are observed. Magnesium level is a determining factor in the variation of serum calcidiol concentrations that should be considered in the assessment of vitamin D status.