Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression

Kayhan, Fatih; Gündüz, Şule; Ersoy, Sevde Afife; Kandeğer, Ali; Annagür, Bılge Burçak

doi:10.1016/j.psychres.2016.11.016

Cited by 83 publications

(65 citation statements)

References 25 publications

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“…Activated platelets may induce the formation of a thrombus in patients suffering from depression, and increased serotonin levels may further alter the functions of platelets in these patients (54). It has previously been shown that an increased PLR is associated with severe major depression and that it may lead to psychotic symptoms (51). Raised PLRs have also been associated with acute ishemic stroke patients (55).…”

Section: Discussionmentioning

confidence: 99%

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Wei

Zhou

et al. 2020

Exp Ther Med

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Post-stroke depression (PSD) is the most prevalent psychiatric complication of acute ischemic stroke. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are indicators of inflammation and are associated with stroke and depression. Therefore, the purpose of the present study was to examine the relationship between NLR/PLR and PSD. Retrospective analysis was carried out in 376 patients with first-ever acute ischemic stroke in the First Affiliated Yijishan Hospital of Wannan Medical College between March 2015 and September 2017. Patients were divided into PSD (n=104; 27.7%) and non-PSD (n=272; 72.3%) groups according to the Diagnostic and Statistical Manual of Mental Disorders-IV criteria at 6 months after stroke. Clinical data were collected retrospectively. NLR and PLR were acquired retrospectively from the routine blood tests performed at admission. A total of 120 healthy volunteers from the physical examination center in the First Affiliated Yijishan Hospital of Wannan Medical College were recruited as controls. Using logistic regression analysis, NLR (≥4.02) and PLR (≥203.74) were independently associated with PSD. NLR, odds ratio (OR) 3.926, 95% confidence intervals (CI, 2.365-7.947), P<0.001; PLR, OR 3.853, 95% CI (2.214-6.632), P=0.002. The ability of the combined index [area under the receiver operating characteristic curve, 0.701; 95% CI (0.622-0.780); P<0.001] to diagnose PSD was greater than that of either ratio alone. Higher NLRs and PLRs (≥4th quartile) were associated with PSD with a 5.79-fold (P<0.001) increase compared with lower levels of both. Higher NLRs and PLRs were found to be associated with depression 6 months after stroke, and the combined index was more meaningful than either alone in the early clinical detection of PSD.

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Section: Discussionmentioning

confidence: 99%

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Wei

Zhou

et al. 2020

Exp Ther Med

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“…Hamilton Depression Rating Scale: The Hamilton depression rating scale is used to measure the severity of depression. The score ranges of the scale (0-7) represent no depression; (8)(9)(10)(11)(12)(13)(14)(15)(16) mild depression; (17-23) moderate depression; (≥24) and severe depression [13]. A 50% decrease in the HamD scale equates to response to [14] treatment.…”

Section: Assessment Toolsmentioning

confidence: 99%

“…Repeated studies have reported an increase in the N/L ratio, a subclinical inflammatory marker in Major Depression [6,7]. Recently, the P/L ratio has been used to determine inflammation [8]. It has been reported that the P/L ratio increases in psychotic and severe major depression [8].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the P/L ratio has been used to determine inflammation [8]. It has been reported that the P/L ratio increases in psychotic and severe major depression [8]. The number of studies on the anti-inflammatory effects of antidepressants prescribed for major depression has been increasing recently, and it is thought that even anti-inflammatory agents can serve as clinically relevant antidepressants [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil/Lymphocyte ratio in patients with major depression and the impact of electroconvulsive therapy

2020

Ann Clin Anal Med

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Aim: An accumulation of evidence supports the role of inflammation in the etiology of depression, particularly in severe depression. In this study, we aimed to investigate the effect of electroconvulsive therapy (ECT) treatment on the rates of neutrophil/lymphocytes (N/L), platelets/lymphocyte (P/L) which are subclinical inflammatory markers in patients with moderate/severe depression who went into remission. Materials and Methods: Patients with major depression who had been admitted to hospital in the preceding 2 years with a diagnosis of major depression according to DSM 5 and who had undergone ECT were included in this study as well as a similar number of patients were included as a control group. The groups were compared with respect to the subclinical inflammatory markers N/L, P/L at baseline and after ECT. Fifty-seven patients were compared with respect to N/L, P/L ratios before and after ECT. Results: A total of 116 patients were included in the study, of whom 57 had major depression and 59 were in the control group. The N/L values were significantly higher in the pre-ECT patient group compared to the control group. The post-ECT N/L value was significantly higher compared to the control group and no difference was found between the P/L ratios. There was no significant difference between pre and post-ECT N/L, P/L values in the patient group. Discussion: This study suggests the presence of subclinical inflammation in moderate to severe major depression patients which persists after ECT. Largescale studies are needed to determine the effects of ECT on inflammation.

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“…12,13 Studi yang dilakukan oleh Kayhan, dkk. 14 juga menemukan nilai RTL terkait dengan depresi berat yang disertai dengan gejala psikotik. Namun, studi-studi lain terkait dengan RTL pada pasien depresi belum menemukan hubungan yang signifikan terkait kondisi inflamasi yang terjadi pada depresi.…”

Section: Pendahuluanunclassified

Gambaran Darah Tepi, Rasio Neutrofil-Limfosit, dan Rasio Trombosit-Limfosit pada Pasien Tuberkulosis Paru dengan Depresi

Shatri¹,

Alexander²,

Putranto³

et al. 2019

JPDI

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Pendahuluan. Pasien dengan tuberkulosis (TB) paru memiliki peningkatan risiko untuk mengalami depresi sampai 1,53 kali dari sebuah studi kohort besar. Studi – studi menemukan adanya peningkatan rasio neutrofil – limfosit (RNL) pada berbagai gangguan mood termasuk depresi, juga rasio trombosit – limfosit (RTL) terkait dengan depresi berat yang disertai dengan gejala psikotik. Penelitian ini dilakukan untuk mengetahui karakteristik gambaran darah tepi, RNL, dan RTL pada pasien TB paru yang mengalami depresi.Metode. Studi dengan desain potong lintang dilakukan terhadap 106 pasien TB paru tidak resisten obat yang berobat jalan di poliklinik paru RS Cipto Mangunkusumo, Jakarta dari bulan Agustus hingga Oktober 2018. Diagnosis depresi ditegakkan dengan wawancara menurut kriteria diagnosis dari Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) dan derajat depresi ditentukan menggunakan kuesioner Beck Depression Inventory-II (BDI-II). Pemeriksaan laboratorium dilakukan untuk mendapatkan hasil darah perifer lengkap, RNL, dan RTL. Uji statistik parametrik digunakan untuk variabel-variabel numerik dengan sebaran merata, sementara uji nonparametrik digunakan bila sebaran tidak merata.Hasil. Dari 106 pasien TB paru tidak resisten obat yang menjadi subjek penelitian, didapatkan proporsi depresi sebesar 32%. Didapatkan nilai leukosit lebih rendah pada pasien TB paru dengan depresi (p=0,024), dan juga nilai limfosit absolut yang lebih rendah pada pasien TB paru dengan depresi (p=0,004) bila dibandingkan dengan subjek tanpa depresi. Rasio neutrofil – limfosit (RNL) dan RTL tidak berhubungan signifikan secara statistik (p>0,05) dengan beratnya derajat depresi. Simpulan. Nilai hitung leukosit dan limfosit pada pasien TB paru dengan depresi lebih rendah dibandingkan pasien tanpa depresi. Nilai RNL dan RTL pada pasien depresi dengan TB paru lebih tinggi walaupun tidak signifikan secara statistik. Kata Kunci: Depresi, Gambaran darah tepi, Rasio neutrofil – limfosit, Rasio trombosit – limfosit, Tuberkulosis paruPeripheral Blood Count Characteristics, Neutrophil-Lymphocyte Ratio, and Platelet-Lymphocyte Ratio Pulmonary Tuberculosis Patients with DepressionIntroduction. Patients with pulmonary tuberculosis (TB) had an increased risk for depression up to 1.53 times from a large cohort study. Studies have found an increase in the neutrophil - lymphocyte ratio (NLR) in various mood disorders including depression, also the value of the platelet-lymphocyte ratio (PLR) associated with major depression accompanied by psychotic symptoms. This study aimed to describe the peripheral blood characteristics, NLR, and PLR in pulmonary TB patients with depression. Methods. A cross-sectional study of 106 non-multidrug-resistant pulmonary TB patients was done at outpatient department of Cipto Mangunkusumo General Hospital, Jakarta from August to October 2018. The diagnosis of depression was made by interview according to Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) criteria, and severity of depression is determined using Beck Depression Inventory-II (BDI-II). The laboratory tests were done to obtain complete peripheral blood results, NLR, and TLR. Parametric test was used for numeric variables with even distribution, and nonparametric test for variables with uneven distribution.Results. From 106 patients with non-multidrug-resistant pulmonary TB, the proportion of depression was 32%. White blood cell count (p=0.024), and absolute lymphocte count (p=0.004) is lower in depressed TB patients compared to nondepressed TB patients. There were no significant relationship between NLR and TLR and the severity of depression in depressed pulmonary TB patients (p>0.05). Conclusion. White blood cell count and absolute lymphocyte count are lower in depressed pulmonary TB patients. Meanwhile, RNL and PLR are higher in depressed pulmonary TB patients eventhough not statistically significant.

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Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression

Cited by 83 publications

References 25 publications

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Elevated neutrophil‑to‑lymphocyte and platelet‑to‑lymphocyte ratios predict post‑stroke depression with acute ischemic stroke

Neutrophil/Lymphocyte ratio in patients with major depression and the impact of electroconvulsive therapy

Gambaran Darah Tepi, Rasio Neutrofil-Limfosit, dan Rasio Trombosit-Limfosit pada Pasien Tuberkulosis Paru dengan Depresi

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