Relative importance of estrogen and progesterone receptor assays as prognostic indicators in primary breast cancer: a short-term study.

Brocklehurst, D.; Wilde, C. E.; Finbow, J. A. H.; Brett, R; Champion, A.E.; Dewhurst, David

doi:10.1093/clinchem/35.2.238

Cited by 9 publications

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“…Thus, in one study, the small number of patients with tumors containing only PR had disease-free intervals similar to those with tumors containing both receptors. 5 Few results have been published in dogs. In one study, dogs with tumors containing only PR were determined to have a higher survival rate, compared with dogs lacking ERα and PR.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog

2005

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Abstract. The immunohistochemically determined estrogen receptor (ER) ␣ (ER␣) and progesterone receptor (PR) status, as well as recognized, well-accepted prognostic indicators and host factors were prospectively analyzed in 84 cases of primary canine mammary carcinoma for their effect on disease-free period (recurrence free, metastasis free, or combined) (DFP) after an observation period of 18 months. The presence of one or both receptors, as well as tumor size, lymph node status, histologic grading, intravascular growth, and necrosis, were of prognostic value for DFP. In multivariate analysis, only tumor size and histologic grading proved to be independent prognosticators. None of the host factors analyzed were of prognostic value for DFP. ER␣, PR, or both were detected in 173 out of 228 tumors: 70 ER␣ and PR; 5 ER␣ only; 98 PR only. Statistically significant differences regarding the presence of one or both receptors were observed between benign and malignant tumors and between complex, mixed, and simple histologic subtypes of benign and malignant tumors. In the group of malignant tumors (n ϭ 155), the presence of one or both receptors was more frequent in tumors smaller than 3 cm, without lymph node metastasis, with tubulopapillary rather than solid patterns of growth among simple carcinomas, of histologic grades I and II, without both intravascular growth and necrosis, and with lymphocyte cell infiltrates. The most frequent groups of hormone receptors-positive tumors were the ER␣-positive and PRpositive group among benign and the ER␣-negative and PR-positive group among malignant tumors.

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Section: Discussionmentioning

confidence: 99%

A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog

2005

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Defining the high-risk breast cancer patient

Clark¹,

McGuire²

1992

Adjuvant Therapy of Breast Cancer

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The prognosis of patients with gastric cancer possessing sex hormone receptors

et al. 1992

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Estrogen receptors (ER) and progesterone receptors (PgR) were immunohistologically investigated in 107 patients with gastric cancer who underwent curative resection. Both ER and PgR were detected only in the cancer cell nucleus. The ER positive rate was 27.7% for males and 31.0% for females, while the PgR positive rate was 9.2% for males and 11.9% for females. Clinicopathologically, the ER positive rate was slightly higher in young females and in cases of poorly differentiated gastric cancer. When cumulative survival rates were analyzed in relation to the presence or absence of receptors, the 10-year cumulative survival rate after surgery was significantly lower in the ER positive cases, being 15.7% cent, than in the ER negative cases, being 62.7%, and also significantly lower in the PgR positive cases, being 18.2%, than in the PgR negative cases, being 48.3%. The coexistence of ER and PgR in gastric cancer tissues suggests that the ER is physiologically active, or that ER positive gastric cancer is hormone-dependent. The poor prognosis of patients with receptor positive gastric cancer suggests that gastric cancer with these receptors is highly malignant.

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Relative importance of estrogen and progesterone receptor assays as prognostic indicators in primary breast cancer: a short-term study.

Cited by 9 publications

References 0 publications

A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog

A Prospective Analysis of Immunohistochemically Determined Estrogen Receptor α and Progesterone Receptor Expression and Host and Tumor Factors as Predictors of Disease-free Period in Mammary Tumors of the Dog

Defining the high-risk breast cancer patient

The prognosis of patients with gastric cancer possessing sex hormone receptors

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