Relative time-intensity curve: a new method to differentiate benign and malignant lesions on breast MRI

Sherif, Hanan; Mahfouz, Ahmed; Kambal, Aalaa; Sayedin, Ahmed; Mujeeb, Imad Bin

doi:10.1186/1470-7330-14-s1-p26

Cited by 1 publication

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“…The potential in the application of TIDC, as a means of detecting tumor aggressiveness was seen using 3DQI software. Time-Density Curves for CT scans and Time-Intensity Curves for MRI scans provide a visual tool for the enhancement or reduction of a particular mass/lesion over time based on the intensity and density (22)(23)(24)(25). Previous studies have demonstrated the utility of TIDC analysis in differentiating solid lesions in the pancreas using contrast-enhanced EUS (16), a first line diagnostic test (26)(27)(28)(29).…”

Section: Time-intensity-density Curvesmentioning

confidence: 99%

Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma

et al. 2021

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PurposeThere is a major shortage of reliable early detection methods for pancreatic cancer in high-risk groups. The focus of this preliminary study was to use Time Intensity-Density Curve (TIDC) and Marley Equation analyses, in conjunction with 3D volumetric and perfusion imaging to demonstrate their potential as imaging biomarkers to assist in the early detection of Pancreatic Ductal Adenocarcinoma (PDAC).Experimental DesignsA quantitative retrospective and prospective study was done by analyzing multi-phase Computed Tomography (CT) images of 28 patients undergoing treatment at different stages of pancreatic adenocarcinoma using advanced 3D imaging software to identify the perfusion and radio density of tumors.ResultsTIDC and the Marley Equation proved useful in quantifying tumor aggressiveness. Perfusion delays in the venous phase can be linked to Vascular Endothelial Growth Factor (VEGF)-related activity which represents the active part of the tumor. 3D volume analysis of the multiphase CT scan of the patient showed clear changes in arterial and venous perfusion indicating the aggressive state of the tumor.ConclusionTIDC and 3D volumetric analysis can play a significant role in defining the response of the tumor to treatment and identifying early-stage aggressiveness.

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