Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99mTechnetium-fluconazole nanocapsules

Assis, Danielle Nogueira de; Mosqueira, Vanessa Carla Furtado; Vilela, José Mário Carneiro; Andrade, Margareth Spangler; Cardoso, Valbert Nascimento

doi:10.1016/j.ijpharm.2007.08.002

Cited by 96 publications

(44 citation statements)

References 32 publications

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“…PLC NC showed reduced sizes compared to CS-PCL NC and these results are in agreement with those obtained by Calvo et al [21] for similar formulations. However, the mean size of the nanocapsules obtained in the present work were slightly different from those previously reported for nanocapsules encapsulating other radiopharmaceuticals [6,22], probably due to differences in the type of the polymers and their average molecular weights, the excipients and their proportion. The mean size of unloaded and 99m Tc-MIBI loaded NC were not similar.…”

Section: Nanocapsules Characterizationcontrasting

confidence: 99%

“…This observation can be explained by a possible NC flattening and aggregation process that takes place after drying on a glass surface. In fact, the flattening phenomenon was probably related to variations in polymeric wall thickness and in its homogeneity, and it is in accordance with previous works [6,22,26]. The diameter/height ratios were calculated from the topographical profile of AFM.…”

Section: Nanocapsules Characterizationsupporting

confidence: 88%

“…The detection of anti-inflammatory or antibiotics and their residues in the biological media is not desirable and limits are established [2]. They have been identified and quantified in animal derived products using different methods, such as high-performance liquid chromatography (HPLC) [3], micellar electrokinetic capillary chromatography with indirect laser-induced fluorescence [4], ultrahigh performance liquid chromatography-tandem mass spectrometry [5], and scintillation counter [6].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Araújo

Fuscaldi

Takenaka

et al. 2014

J Radioanal Nucl Chem

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Nanocapsules (NCs) of poly-e-caprolactone (PCL NC) and poly-e-caprolactone coated with chitosan (CS-PCL NC) loaded with technetium-99m methoxyisobutylisonitrile ( 99m Tc-MIBI) were employed as a model to understand the role of these nanocarriers in the veterinary area. 99m Tc-MIBI-NCs and 99m Tc-MIBI were administrated by intramammary via in rats. The level of radioactivity in the blood was lower when NCs were employed in all times investigated. The results obtained suggest that NCs could be an alternative method for treatment of intramammary diseases in animals, once the data showed high retention in this tissue, increasing the drug residence time on the target.

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Section: Nanocapsules Characterizationcontrasting

confidence: 99%

Section: Nanocapsules Characterizationsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Araújo

Fuscaldi

Takenaka

et al. 2014

J Radioanal Nucl Chem

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“…Antimikrobial peptid ubikuitin (29-41) Tc-99m ile işaretlenerek [Tc-99m ubikuitin (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)] Staphlococcus aureus ve Escherichia coli enfeksiyonlu ve enflamasyonlu tavşanlarda çalışılmıştır. Escherichia coli'de daha düşük tutulum gösterdiği tespit edilmiş ve bu peptidin Escherichia coli mikrobiyal membranına afinitesinin daha düşük olmasıyla açıklamıştır.…”

Section: Radyo-işaretli Peptid çAlışmaları Ve Etki Mekanizmalarıunclassified

Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Acar¹,

Sevinç²,

Bekiş³

2017

Nts

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Enfeksiyon-Enflamasyon: Moleküler Görüntülemede Kullanılan SPECT RadyofarmasötikleriFunctional and metabolic Nuclear medicine imaging techniques demonstrate infectious as well as inflammed foci before the presence of any anatomical sign. Numerous techniques have been developed for scintigraphic visualisation of infection and inflammation for a period of more than a half century. Specific as well as nonspecific radiopharmaceuticals have been utilised. The uptake mechanisms of non-specific agents are mostly dependant on changes in vascular permeability. That's why it is not possible to distinguish infection and inlammation using non-specific agents. Ga-67 citrate can also be used for diagnosis of infection in several pathological cases. The uptake mechanism of Ga-67 citrate in infectious foci is dependent on many factors but binding to transferin in the circulating blood is the initial step. On the other hand In-111 oxin or Tc-99m labelled immunoglobulin are accumulated at the infection site with the activation of Fc-ɣ receptors in the leukocytes. Although In-111 and Tc99m labelled leukocyte scıntigraphy have been developed in the 1970s, this method has been still a golden one. As the isolation and labelling process of luekocytes is time consuming and involved some risk factors, the researches have been investigating ways to develop spesific agents which will trap in leucosite in vivo. Tc-99m and I-123 labelled antigranulocyte antibodies, peptides, cytokines, all of which will target and bind leukocyte receptors have been used to visualise infections. Additionally antibiotics and antimicrobial peptides have been labelled with radionuclides in vivo, in order to carry out spesific visualisation techniques.

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“…The surface topography of sample is based on the force between tip and sample surface. AFM can also be used for imaging non conducting samples in their native state without any chemical treatment (DeAssis et al 2008). AFM also provides 3-D image of sample surface.…”

Section: Characterisation Of Nanoscale Materialsmentioning

confidence: 99%

Nanoscale Materials in Targeted Drug Delivery

Kumari

Singla

Guliani

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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Nanoscale materials (NSMs) are gaining attention due to their small size and unique physiochemical properties. Different approaches are used for the synthesis of NSMs. NSMs cannot be visualized by ordinary instruments. Instruments with high resolution are required for their characterisation. NSMs offer enhanced activity and specificity to encapsulate drugs. NSM are used as vehicles for site specific delivery of drugs inside the body. In this chapter, approaches for the synthesis of NSMs, and characterisation techniques for NSMs like SEM, TEM, AFM, DLS, XRD, and FTIR have been explained briefly. In addition, this chapter also covers zero dimensional one dimensional, two dimensional and three dimensional NSMs briefly. Detailed information about approaches of targeted delivery like passive and active have been covered in this chapter. NSMs like polymeric nanoparticles, metallic nanoparticles, liposomes, quantum dots, polymeric micelles, carbon nanotubes, dendrimers, and magnetic nanoparticles used in targeted drug delivery have also been explained in this chapter.

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Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of 99mTechnetium-fluconazole nanocapsules

Cited by 96 publications

References 32 publications

Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Characterization and in vivo evaluation of nanocapsules loading 99mTc-MIBI for intramammary study

Sentinel Lymph Node Imaging and Biopsy in Breast Cancer

Nanoscale Materials in Targeted Drug Delivery

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