Relevance Function of Linc-ROR in the Pathogenesis of Cancer

Chen, Wenjian; Yang, Jun; Fang, Hui; Li, Lei; Sun, Jun

doi:10.3389/fcell.2020.00696

Cited by 41 publications

(35 citation statements)

References 145 publications

(224 reference statements)

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“…LincRNAs have been identified as critical regulators in various cellular processes, including cancer initiation and progression. 30 31 Although it has been found that LINC01140 is overexpressed in gastric cancer 17 and regulates the inflammatory response during pulmonary fibrosis, 18 the role of LINC01140 in other disease, including LC, is still not completely understood. Recently, an outstanding work by Allou et al revealed that mutations involving lncRNA loci can result in human Mendelian disease.…”

Section: Discussionmentioning

confidence: 99%

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

Xia

Geng

et al. 2021

J Immunother Cancer

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BackgroundLong intergenic non-protein coding RNA 1140 (LINC01140), a long non-coding RNA, is highly expressed in various cancers; however, its biological functions in lung cancer (LC) progression and immune escape are still unclear.MethodsHere, to elucidate LINC01140 function, 79 paired LC and paracancerous tissues were collected. LINC01140 expression levels were determined using fluorescence in situ hybridization and qPCR analysis. Cell counting kit-8 (CCK-8) assay and transwell assays were performed. The interaction between microRNAs (miRNAs) and LINC01140 was confirmed using an RNA immunoprecipitation assay. Cytokine-induced killer (CIK) cell phenotypes were analyzed by flow cytometry. Cytokine secretion levels were determined by ELISA. CIK cytotoxicity was assessed by measuring lactate dehydrogenase release. Besides, xenograft tumor mouse models were used to unveil the in vivo function of LINC01140.ResultsWe found that LINC01140 was highly expressed in human LC tissues and cell lines. High LINC01140 levels were associated with poor survival in patients with LC. LINC01140 upregulation promoted the proliferation, migration, and invasion of LC cells through direct interaction with miR-33a-5p and miR-33b-5p, thereby contributing to c-Myc expression and also inhibited cisplatin-induced cell apoptosis. In subcutaneous tumor xenograft mice, LINC01140 knockdown markedly reduced tumor growth and lung metastasis. Additionally, LINC01140 directly repressed miR-377-3 p and miR-155-5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy. Notably, we proved that LINC01140 knockdown, along with CIK administration, suppressed the growth of subcutaneous LC xenografts by decreasing PD-L1 expression in severe combined immunodeficient mice.ConclusionsTaken together, LINC01140 overexpression protects c-Myc and PD-L1 mRNA from miRNA-mediated inhibition and contributes to the proliferation, migration, invasion, and immune escape of LC cells. These results provide a theoretical basis that LINC01140 is a promising target for LC treatment.

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Section: Discussionmentioning

confidence: 99%

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

Xia

Geng

et al. 2021

J Immunother Cancer

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“…ROR was initially discovered as a promoter of the reprogramming process, and it was shown to contribute to the maintenance of pluripotent and embryonic stem cells via inhibition of cellular stress signaling pathways ( 159 ). Elevated ROR expression has been detected across cancer cell lines ( 160 ). Recent studies have shown that ROR promotes EMT in various cancers ( 161 , 162 ).…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects

Wei

Zhang

et al. 2021

Front. Oncol.

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Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of utmost importance. Long non-coding RNAs (lncRNAs) are commonly defined as transcripts longer than 200 nucleotides that lack coding potential. Extensive research has shown that lncRNAs are involved in multiple human cancers, including breast cancer. LncRNAs with dysregulated expression can act as oncogenes or tumor-suppressor genes to regulate malignant transformation processes, such as proliferation, invasion, migration and drug resistance. Intriguingly, the expression profiles of lncRNAs tend to be highly cell-type-specific, tissue-specific, disease-specific or developmental stage-specific, which makes them suitable biomarkers for breast cancer diagnosis and prognosis.

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“…Aberrations in the ceRNA network can lead to pathological conditions and cancer development [229]. LINC-ROR, acting as a ceRNA in ESCs, is involved in the occurrence and development of different human tumors (breast cancer, colorectal cancer, pancreatic cancer, hepatocellular carcinoma), and it represents a potential biomarker with clinical significance that can be used as therapeutic target [230]. In colon cancer stem cells, as in ESCs, LINC-ROR acts as a ceRNA to prevent miR-145-mediated suppression of NANOG, OCT4, and SOX2 TFs to regulate cell proliferation and chemosensitivity [231].…”

Section: Regulation Of Mirnas Through Competitive Endogenous Rnas In Escs and Cscsmentioning

confidence: 99%

MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development

et al. 2021

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Embryonic stem cells (ESCs) have the extraordinary properties to indefinitely proliferate and self-renew in culture to produce different cell progeny through differentiation. This latter process recapitulates embryonic development and requires rounds of the epithelial–mesenchymal transition (EMT). EMT is characterized by the loss of the epithelial features and the acquisition of the typical phenotype of the mesenchymal cells. In pathological conditions, EMT can confer stemness or stem-like phenotypes, playing a role in the tumorigenic process. Cancer stem cells (CSCs) represent a subpopulation, found in the tumor tissues, with stem-like properties such as uncontrolled proliferation, self-renewal, and ability to differentiate into different cell types. ESCs and CSCs share numerous features (pluripotency, self-renewal, expression of stemness genes, and acquisition of epithelial–mesenchymal features), and most of them are under the control of microRNAs (miRNAs). These small molecules have relevant roles during both embryogenesis and cancer development. The aim of this review was to recapitulate molecular mechanisms shared by ESCs and CSCs, with a special focus on the recently identified classes of microRNAs (noncanonical miRNAs, mirtrons, isomiRs, and competitive endogenous miRNAs) and their complex functions during embryogenesis and cancer development.

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Relevance Function of Linc-ROR in the Pathogenesis of Cancer

Cited by 41 publications

References 145 publications

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects

MicroRNAs and Stem-like Properties: The Complex Regulation Underlying Stemness Maintenance and Cancer Development

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