Relevance of circulating immune complexes in childhood acute lymphoblastic leukaemia

Clague, R B; Kumar, Shant; Hann, Ian; Jones, Patricia B.; Holt, P J

doi:10.1002/ijc.2910220302

Cited by 12 publications

(11 citation statements)

References 5 publications

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“…This study, performed by Clq-BA and KgB-SP, confirms the previously reported increase of CIC in leukaemic sera Claque et al, 1978;Minden et al, 1980;Doan et al, 1980). The two methods were selected because of their different pattern of reactivity (Casali et al, 1977).…”

Section: Discussionsupporting

confidence: 84%

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Circulating Immune Complexes in Human Acute Leukaemia

et al. 1981

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Circulating immune complexes (CIC) in the sera of 60 newly diagnosed leukaemic patients were investigated by two methods, 125I-C1q binding test (C1q-BA) and conglutinin binding assay (KgB-SP). Positivity percentages were respectively 20.0% (C1q-BA) and 28.3% (KgB-SP). The small overlap between the results of the two methods suggests the occurrence of different types of CIC. The presence of CIC was found to be related only to clinical haemorrhage and thrombocytopenia; it did not prove to affect the prognosis and the survival of leukaemic patient.

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Section: Discussionsupporting

confidence: 84%

“…A striking correlation between CIC and a low incidence of complete remission or even short survival was reported by Carpentier et a1 (1977) in acute leukaemia, using lZ5I-Clq binding assay (Clq-BA). Nevertheless, by the same method, other workers failed to confirm the prognostic value of CIC in acute pediatric leukaemia (Claque et al, 1978;Minden et al, 1980).…”

mentioning

confidence: 99%

Circulating Immune Complexes in Human Acute Leukaemia

et al. 1981

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“…Most patients who lacked detectable immune complexes entered remission, while the patients with detectable immune complexes did not. The specificity of the detected immune complexes can not be demonstrated with this technique and the significance of the results has been questioned (Claque et al, 1978) on the basis of a demonstrated strong correlation between presence of immune complexes and a history of recent infection and lack of correlation to the prognosis of the leukemic disease. In the present investigation no significant specific complement-dependent cytotoxicity against autochthonous leukemia cells could be detected in the untreated sera from seven patients with acute myelogenous leukemia harvested at the acute stage of the disease before initiation of any therapy.…”

Section: Discussionmentioning

confidence: 94%

Possibly specific immune complexes in sera of patients with untreated acute myelogenous leukemia

Fäldt

Ankerst

1980

Intl Journal of Cancer

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Eleven patients with acute myelogenous leukemia (AML) in the acute stage of the disease were studied. Sera of seven patients were assayed for complement-dependent cytotoxicity to autochthonous AML cells and sera of four patients were tested with allogeneic target cells before and after ultrafiltration at low pH. No specific cytotoxic activity could be detected in any untreated sera. Ultrafiltration at low pH led, however, to the appearance of a significant cytotoxic activity in all of seven autochthonous and in three of four allogeneic combinations. Identical treatment of control AB sera did not result in any similar activity. The results show that potentially cytotoxic antibodies to leukemia-associated antigens are present in the acute stage of acute myelogenous leukemia. However, they do not express complement-dependent cytotoxicity in untreated sera. After ultrafiltration at low pH significant complement-dependent cytotoxicity was detectable in most of the sera. One possible explanation is that cytotoxic antibodies to leukemia-associated antigens are present in the form of circulating immune complexes. Splitting of them at low pH and elimination of the antigen component might result in an increased amount of free cytotoxic antibodies.

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“…Nevertheless, other authors [23] did not find a correlation between CIC levels obtained by the solid-phase bovine conglutinin test and clinical status in nonlymphatic leukemia. Clague et al [8], using the Ciq radioiodinated assay did not observe any correlation between the presence of CIC and the prognosis in ALL, although they observed a strong correlation with a history of recent infection.…”

Section: Discussionmentioning

confidence: 96%

“…There are several reports concerning the correlation of circulating immune complex (CIC) levels and the clinical status of malignant disease, including leukemia [1,5,8,15,17]. It has been suggested that immune complexes may inOffprint requests to : A. Segal-Eiras duce tumor progression changing the immune response of the host against malignant cells [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical importance of circulating immune complexes in human acute lymphoblastic leukemia

Croce

Fejes

Riera

et al. 1985

Cancer Immunol Immunother

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A total of 122 sera from acute lymphoblastic leukemia (ALL) patients were analyzed for circulating immune complexes (CIC) by two methods: the 125I-Clq binding assay and the polyethylene glycol precipitation test (PEG). The results were correlated with induction, remission and relapse stages of the disease. Using the first method the levels of CIC in induction were 15.18 +/- 9.15, with 19/29 positive cases (65.50%), P less than 0.001 compared with controls. In the remission phase the levels were 9.02 +/- 5.62, 11/45 (24.49%) nonsignificant P value, and in relapse they were 16.14 +/- 11.17 28/48 (58.33%) P less than 0.001. The PEG precipitation test results were: 0.33 +/- 0.10, 8/22 (36.36%); 0.24 +/- 0.11, 10/48 (20.83%) and 0.28 +/- 0.10, 6/28 (21.42%), respectively. Thus the values of CIC as measured by PEG in the three clinical of phases ALL did not differ significantly from controls. This contrasts with results obtained by the radioiodinated C1q binding assay, where the incidence of positive values was significantly higher in induction and in relapse and lower in the remission phase. These observations were extended in sequential vertical studies performed in a group of patients. These results suggest that raised CIC detected by the 125I-C1q method may reflect a progressive state in ALL and that quantitation of these immune complexes may provide an adequate biochemical marker for prognosis.

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Relevance of circulating immune complexes in childhood acute lymphoblastic leukaemia

Cited by 12 publications

References 5 publications

Circulating Immune Complexes in Human Acute Leukaemia

Circulating Immune Complexes in Human Acute Leukaemia

Possibly specific immune complexes in sera of patients with untreated acute myelogenous leukemia

Clinical importance of circulating immune complexes in human acute lymphoblastic leukemia

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