Relevant pharmacological interactions between alkylating agents and antiepileptic drugs: Preclinical and clinical data

Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients

“…and excretion is largely through kidneys [43]. Previous studies confirmed that concomitant AEDs might reduce the LEV concentration/dose ratio [44,45], while LEV and TMZ did not affect each other's kinetics, although they share a primary renal excretion [46]. Again, excluding two, all patients received LEV monotherapy and did not suffer from other confounders, such as impaired kidney function.…”