The water supply system (WSS) is usually collected from the water source, transmission pipes, treatment plants and water distribution networks to taps and usually exposed to various risks. However, this study provides a framework for WSS that provides drinkable water to various Cairo regions. The scope of work consisted of two main parts, at the first part, the methodology for risk management in Cairo water system will be adopted by assessment of common risks in water distribution systems (WDS), and these types of risks are classified depended on its effect on the reliability, resilience and sustainability. While, at the second part, Analytic Hierarchy Process (AHP) method is developed to incorporate risk alternatives mitigation based on supply reliability, resilience and sustainability. And therefore supply decision support on the choosing of risk response strategies according to the correspondence between their reference and comparability sequences. The results of this paper showed that several risks represent the main parameter that need to characterize water supply systems and their operations, The application of the frame work mentioned in this study will result in increasing the overall score of Al Amerya Water Treatment Plant (WTP) by 49%; moreover the score of Mostorud WTP will improve by 48%. Additionally, the study provided a base for water utilities to reduce the risk of disobedience and achieve desirable service standards in the short, medium and long term, So Water providers can apply this study framework to assist future evaluation.