Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography

Shah, Sonal; Haq, Adnaan; Toufeeq, Shafak; Tu, Zhanhan; Edawaji, Budor; Abbott, Joseph A.; Gottlob, Irène; Proudlock, Frank A

doi:10.1167/tvst.9.7.43

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…Duration of image acquisition was recorded as were the number of repeats required to achieve a usable image. The images were segmented and analysed by AN and reviewed by ZT/FP whose expertise in OCT comes from a background of ophthalmic research using OCT and other methods [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study

Noah,

Spendlove,

et al. 2024

PLoS ONE

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Introduction Postoperative delirium in older people may result from the interaction between intrinsic brain vulnerability (e.g. neurodegeneration) and precipitating factors (e.g. surgery induced cytokines). Intrinsic brain vulnerability may be overt (e.g. Alzheimer’s disease) or preclinical. In cognitively intact older people presenting for surgery, identification of preclinical neurodegeneration using bedside tools could aid postoperative delirium risk stratification. Thinning of the circumpapillary retinal nerve fibre layer thickness is associated with neurodegenerative disorders e.g. Alzheimer’s disease. We propose that thinning of the retinal nerve fibre layer may be present some older people with postoperative delirium due to preclinical neurodegeneration, albeit to a lesser extent than in overt dementia. Objectives The primary objective: Feasibility of acquiring usable retinal images with the hand-held optical coherence device, at the bedside of older, hip fracture surgery patients. Secondary objective: Comparison of the circumpapillary retinal nerve fibre layer thickness between people who did/did not have postoperative delirium. Proportion of exclusions due to retinal pathology. Method Feasibility study involving 30, cognitively intact, older people recovering from hip fracture surgery. Retinal images were obtained using the hand-held optical coherence tomography device at the participants’ bedside. Imaging was deferred in participants who had postoperative delirium. Results Retinal images that could be assessed for circumpapillary retinal nerve fibre layer thickness were obtained in 26 participants (22 no postoperative delirium, 4 postoperative delirium). The mean circumpapillary retinal nerve fibre layer thickness was lower in the participants who had postoperative delirium compared to those who did not experience postoperative delirium (Mean (95% CI) of 76.50 (62.60–90.40) vs 89.19 (85.41–92.97) respectively). Conclusion Retinal imaging at the patient’s bedside, using hand-held OCT is feasible. Our data suggests that the circumpapillary retinal nerve fibre layer may be thinner in older people who experience postoperative delirium compared to those who do not. Further studies are required.

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Section: Methodsmentioning

confidence: 99%

Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study

Noah,

Spendlove,

et al. 2024

PLoS ONE

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“…Volumetric OCT images were acquired using a 10 mm × 10 mm horizontal raster scan protocol (600 A‐scans × 80 B‐scan). According to a previous study protocol (Shah et al, 2020), images were converted using an ImageJ script into a format that could be imported into Copernicus SR Analysis software (Optopol Technology). Circumpapillary RNFL thickness measurements including average and quadrant‐specific (i.e.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic accuracy of retinal optical coherence tomography in children with a newly diagnosed brain tumour

Nuijts

Stegeman

Porro

et al. 2023

Acta Ophthalmologica

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Purpose To estimate the diagnostic accuracy of circumpapillary retinal nerve fibre layer (RNFL) thickness and macular ganglion cell layer–inner plexiform layer (GCL‐IPL) thickness measurements to discriminate an abnormal visual function (i.e. abnormal age‐based visual acuity and/or visual field defect) in children with a newly diagnosed brain tumour. Methods This cross‐sectional analysis of a prospective longitudinal nationwide cohort study was conducted at four hospitals in the Netherlands, including the national referral centre for paediatric oncology. Patients aged 0–18 years with a newly diagnosed brain tumour and reliable visual acuity and/or visual field examination and optical coherence tomography were included. Diagnostic accuracy was evaluated with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results Of 115 patients included in the study (67 [58.3%] male; median age 10.6 years [range, 0.2–17.8 years]), reliable RNFL thickness and GCL‐IPL thickness measurements were available in 92 patients (80.0%) and 84 patients (73.0%), respectively. The sensitivity for detecting an abnormal visual function was 74.5% for average RNFL thickness and 41.7% for average GCL‐IPL thickness at a specificity of 44.5% and 82.9%, respectively. The PPV and NPV were 33.0% and 82.6% for the average RNFL thickness and 57.1% and 82.2% for the average GCL‐IPL thickness. Conclusion An abnormal visual function was discriminated correctly by using the average RNFL thickness in seven out of ten patients and by using the average GCL‐IPL thickness in four out of ten patients. The relatively high NPVs signified that patients with normal average RNFL thickness and average GCL‐IPL thickness measurements had a relative high certainty of a normal visual function.

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“…Full peripapillary volumetric analysis can be performed wherever possible, using a recently published protocol. 51 …”

Section: Methodsmentioning

confidence: 99%

“…► Full peripapillary volumetric analysis can be performed wherever possible, using a recently published protocol. 51 Where available, retinal parameters will include the following: ► Macular and perimacular retinal thickness. ► Foveal pit width.…”

Section: Handheld Oct Image Acquisition and Analysismentioning

confidence: 99%

Recognition of intracranial hypertension using handheld optical coherence tomography in children (RIO Study): a diagnostic accuracy study protocol

et al. 2022

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IntroductionPaediatric intracranial hypertension (IH) is a rare but serious condition that can pose deleterious effects on the brain and vision. Estimating intracranial pressure (ICP) in children is difficult. Gold standard direct ICP measurement is invasive and carries risk. It is impractical to routinely perform direct ICP measurements over time for all children at risk of IH. This study proposes to assess the diagnostic accuracy of handheld optical coherence tomography (OCT), a non-invasive ocular imaging method, to detect IH in children.Methods and analysisThis is a prospective study evaluating the diagnostic accuracy of handheld OCT for IH in at risk children. Inclusion criteria include clinical and/or genetic diagnosis of craniosynostosis, idiopathic intracranial hypertension, space occupying lesion or other conditions association with IH and age 0–18 years old. Exclusion criteria include patients older than 18 years of age and/or absence of condition placing the child at risk of IH. The primary outcome measures are handheld OCT and 48-hour ICP assessments, which will be used for diagnostic accuracy testing (sensitivity, specificity, positive predictive value, negative predictive value and accuracy). Main secondary outcome measures include visual acuity, fundoscopic examination, contrast sensitivity, visual field testing and visual evoked potentials, wherever possible.Ethics and disseminationEthical approval was granted for this study by the East Midlands Nottingham 2 Research Ethics committee (UOL0348/IRAS 105137). Our findings will be disseminated through presentation at relevant meetings, peer-reviewed publication and via the popular media.Trial registration numberISRCTN52858719

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Reliability and Recommended Settings for Pediatric Circumpapillary Retinal Nerve Fiber Layer Imaging Using Hand-Held Optical Coherence Tomography

Abstract: FA. Reliability and recommended settings for pediatric circumpapillary retinal nerve fiber layer imaging using hand-held optical coherence tomography.

Cited by 9 publications

References 25 publications

Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study

Retinal imaging with hand-held optical coherence tomography in older people with or without postoperative delirium after hip fracture surgery: A feasibility study

Diagnostic accuracy of retinal optical coherence tomography in children with a newly diagnosed brain tumour

Recognition of intracranial hypertension using handheld optical coherence tomography in children (RIO Study): a diagnostic accuracy study protocol

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